Associations of coffee and tea consumption with lung cancer risk

Abstract

Associations of coffee and tea consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow‐up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nontea consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15‐1.47), 1.49 (1.27‐1.74) and 1.35 (1.15‐1.58), respectively. Corresponding HRs for exclusive tea drinkers (≥2 cups/d) were 1.16 (1.02‐1.32), 1.10 (0.92‐1.32) and 1.37 (1.17‐1.61). In general, the coffee and tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher consumption of coffee or tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and tea consumption after study enrolment.

Association between Coffee Consumption/Physical Exercise and Gastric, Hepatic, Colon, Breast, Uterine Cervix, Lung, Thyroid, Prostate, and Bladder Cancer

“…Lung cancer, prostate cancer, and bladder cancer were not correlated with coffee consumption in the present study. Several studies estimated the risk of these cancers [31][32][33][34]. For lung cancer, a prospective cohort study reported an increased risk of lung cancer associated with coffee consumption (hazard ratio (HR) = 1.30, 95% CI = 1.15-1.47) [31].…”

“…Several studies estimated the risk of these cancers [31][32][33][34]. For lung cancer, a prospective cohort study reported an increased risk of lung cancer associated with coffee consumption (hazard ratio (HR) = 1.30, 95% CI = 1.15-1.47) [31]. Another prospective cohort study also reported a higher risk of lung cancer associated with coffee consumption (HR = 1.18, 95% CI = 1.02-1.36) [32].…”

Healthful and Unhealthful Plant-Based Diets and Chronic Obstructive Pulmonary Disease in U.S. Adults: Prospective Study

“…Regarding smoking, the association between plant diet and COPD may be due, in part, to a residual confounding by cigarette smoking, which is a powerful risk factor. To minimize this possibility, multivariable models were adjusted with multiple time-varying measures of tobacco exposure; using this detailed control for smoking as time-dependent variable was able, for example, to reduce an age-adjusted relative risk of 4 for coffee consumption and lung cancer risk to a fully adjusted relative risk of 1.0 [ 32 ]. We also acknowledge that there is some misclassification of diet assessed by the food frequency questionnaire.…”

A Decade of Research on Coffee as an Anticarcinogenic Beverage

“…We provide a wealth of up- Cancer risk is significantly increased by 47% in the population with the highest category intake of coffee compared with that with the lowest category intake. Zhu, 2020 [137] 17 prospective cohort studies (1.1 million Pt and 20,280 Cc) Uninformed Higher consumption of coffee is associated with increased cancer risk.…”