Associations of childhood adiposity and changes in adiposity status from childhood to adulthood with pregnancy hypertension

He, Ye; Tian, Jing; Blizzard, Leigh; Oddy, Wendy H.; Dwyer, Terence; Venn, Alison

doi:10.1016/j.preghy.2019.11.006

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…Obesity among pregnant women increased in Iceland until 2005‐2006, and then levelled off until 2010, 22 yet may still be related to the increasing prelabor cesarean birth rates for older women in our study. However, high BMI is associated with hypertension and diabetes 23,24 and we were able to adjust for both of these risk factors in our study. Furthermore, BMI is associated with socioeconomic status, 25 and in a subsample of our data, BMI was associated with employment, residency, and country of origin, but not marital status.…”

Section: Discussionmentioning

confidence: 88%

Trends in cesarean birth rates in Iceland over a 19‐year period

Haggar

Einarsdóttir

2020

Birth

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Background Cesarean birth (CB) rates have increased in high‐resource countries during the past two decades, yet it is not known whether CB rates have changed according to maternal age and/or gestational age. Methods All singleton live births in Iceland between 1997 and 2015 were identified from the Icelandic Medical Birth Registry (80 130). Rates of cesarean births (intrapartum and prelabor) were calculated overall and separately for maternal age groups and gestational age groups and by parity. Logit binomial regression was used to calculate odds ratios (ORs) and confidence intervals (CIs) for annual change in cesarean birth rates adjusted for maternal characteristics and clinical indication groups. Results The overall CB rate was 15.7% in 1997 and 15.8% in 2015; the CB rate did not change significantly during the study period. The overall CB rate for early‐term deliveries (37‐38 weeks) decreased for multiparas (annual aOR = 0.99 [95% CI = 0.98‐0.99]), and the preterm (<37 weeks) prelabor cesarean rate increased significantly (1.11 [1.09‐1.14]) for both primiparas and multiparas. For multiparas only, the intrapartum CB rate decreased (0.97 [0.97‐0.98]), whereas the prelabor CB rate increased, predominantly for women aged over 35 years (1.03 [1.02‐1.04]). Adjustment for clinical indication groups did not change these results. Conclusions Findings indicate a rise in prelabor cesarean for preterm births and women aged over 35 years (multiparas only). As adjustment for clinical indications did not affect these results, changes in obstetric practice are more likely to have affected these rate changes rather than changes in clinical indications.

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Section: Discussionmentioning

confidence: 88%

Trends in cesarean birth rates in Iceland over a 19‐year period

Haggar

Einarsdóttir

2020

Birth

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“…Further comparisons of inflammatory factors indicated that HMGB1, Hcy and serum CysC levels in the two groups were significantly lower after treatment, and those in the Expt group were also markedly lower than those in the Ctrl group after treatment (P<0.05). HMGB1 is a crucial late-stage pro-inflammatory factor, which has greater clinical significance than tumor necrosis factor (TNF), interleukin-1 and other early-stage immediate inflammatory factors ( 37 ). In addition, numerous studies have identified the close connection between HMGB1 and TNF-α ( 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of magnesium sulfate combined with labetalol on inflammatory stress and pregnancy outcome of patients with gestational hypertension

Gu,

Zhang

et al. 2024

Exp Ther Med

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Gestational hypertension (GH) is a common disorder during pregnancy that can cause adverse pregnancy outcomes. In the present study, magnesium sulfate (MgSO 4 ) combined with labetalol was used for clinical treatment. Randomized controlled trial was conducted in 100 patients with GH, documented in the Department of Obstetrics and Gynecology (Taicang TCM Hospital) grouped into the experimental (Expt) and control (Ctrl) groups (n=50 cases/group). The Ctrl group was treated with MgSO 4 , whereas the Expt group was treated with MgSO 4 + labetalol. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the Expt group were not significantly different from those in the Ctrl group (P>0.05). By contrast, the SBP and DBP were significantly lower after treatment than those before treatment in both groups (P<0.05). Whole blood viscosity, plasma viscosity and hematocrit were significantly lower in the Expt group compared with those in the Ctrl group after treatment (P<0.05). High mobility group box-1 protein, homocysteine and serum cystatin C levels in the Expt group were also markedly lower than those in the Ctrl group after treatment (P<0.05). In the Expt group, the rate of spontaneous vaginal delivery was much higher, whereas the rates of cesarean section and postpartum hemorrhage were markedly lower than those in the Ctrl group (P<0.05). The occurrence of fetal intrauterine distress, placental abruption, neonatal asphyxia, premature birth and neonatal death were also significantly lower in the Expt group than those in the Ctrl group (P<0.05). In conclusion, MgSO 4 + labetalol could improve inflammatory stress and the hemodynamics of patients with GH, and may have a marked antihypertensive effect. Thus, it may improve pregnancy outcome and reduce perinatal complications.

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“…Childhood obesity was found to be a risk factor for hypertension, cardiovascular and cerebrovascular diseases, diabetes, and a host of other health problems, according to previous observational studies [24]. The incidence of pregnancy hypertension with childhood overweight and childhood abdominal obesity was examined in a nearly 20-year cohort study with 3412 female participants; results revealed a higher risk of childhood adiposity with an increased risk of pregnancy hypertension [childhood overweight, relative risk (RR) ¼ 1.66, 95% CI 1.07-2.52; abdominal obesity RR ¼ 2.55, 95% CI 1.34-4.85] [5]. Another cohort study of 49 600 nulliparous women indicated that BMI at ages 7 and 13 years increased above the average level, and so did the risks of gestational hypertension and preeclampsia, as BMI increased above average, RR for hypertension in pregnancy was 1.66 (95% CI 1.42-1.94) and for preeclampsia was 1.57 FIGURE 6 Leave-one-out plot to visualize causal effect of childhood obesity on the risk of hypertension in pregnancy when leaving one single-nucleotide polymorphism out.…”

Section: Discussionmentioning

confidence: 99%

“…These findings revealed that childhood obesity might be an independent risk factor for pregnancy-related hypertension. According to Mendelian randomization research, children who are obese have an increased risk of developing essential hypertension [ 5 ]; furthermore, another Mendelian randomization study discovered a direct link between pregnancy-related hypertension issues and obesity [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple pregnancies, parity, and history of preeclamptic pregnancies are all risk factors for hypertension in pregnancy, along with some cardiovascular risk factors, such as obesity, hypertension, type 2 diabetes, and hyperlipidemia [ 3 ]. Traditional risk factor such as obesity – BMI greater than 35 kg/m 2 were also been identified [ 5 , 6 ].…”

Section: Introdutionmentioning

confidence: 99%

See 1 more Smart Citation

Childhood obesity and hypertension in pregnancy: a two-sample Mendelian randomization analysis

Hu¹,

Li³

et al. 2023

Journal of Hypertension

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Background:The causal relationship between childhood obesity and hypertension in pregnancy remains unclear. To examine the causal association between childhood obesity and hypertension in pregnancy, two-sample Mendelian randomization analysis was applied.Methods:Single-nucleotide polymorphisms (SNPs) associated with childhood obesity were obtained from a published genome-wide association study (GWAS) of 13 848 European individuals. Summary-level data for hypertension in pregnancy were obtained from the FinnGen consortium (11534 cases and 162212 controls). Inverse-variance weighted analysis, weighted-median analysis, and Mendelian randomization-Egger regression were conducted in this Mendelian randomization analysis. Sensitivity analyses were conducted to confirm the accuracy and robustness of our results.Results:Genetically determined childhood obesity significantly affects hypertension in pregnancy by IVW [odds ratio (OR) = 1.161, 95% confidence interval (CI) 1.086–1.039; P = 9.92 × 10−6] and weighted median (OR = 1.123, 95% CI 1.038–1.214; P = 0.004). These results were validated by multiple sensitivity analyses.Conclusion:A causal effect between genetically predicted childhood obesity and the risk of hypertension in pregnancy was identified. The prevention of hypertension in pregnancy should be promoted in populations with childhood obesity.

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Associations of childhood adiposity and changes in adiposity status from childhood to adulthood with pregnancy hypertension

Cited by 4 publications

References 28 publications

Trends in cesarean birth rates in Iceland over a 19‐year period

Trends in cesarean birth rates in Iceland over a 19‐year period

Effects of magnesium sulfate combined with labetalol on inflammatory stress and pregnancy outcome of patients with gestational hypertension

Childhood obesity and hypertension in pregnancy: a two-sample Mendelian randomization analysis

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