Associations of cataract with antioxidant enzymes and other risk factors

Delcourt, Cécile; Carrière, Isabelle; Delage, Michel; Descomps, Bernard; Cristol, Jean‐Paul; Papoz, L

doi:10.1016/s0161-6420(03)00713-9

Cited by 44 publications

(23 citation statements)

References 44 publications

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“…It is also known that Zn has antioxidative effects against the development of cataract [12,18,[23][24][25][26]. In an animal study, those rats that were fed a low-Zn diet developed cataractogenesis [27].…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of the Oxidative Stress Parameters in Nondiabetic and Diabetic Senile Cataract Patients

Yıldırım

Yildirim

Uçgun

et al. 2008

Biol Trace Elem Res

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The aim of the present study was to evaluate the copper (Cu), zinc (Zn), malondialdehyde (MDA), glutathione (GSH), and advanced oxidation protein products (AOPP) levels and superoxide dismutase (SOD) activities in diabetic senile cataract. Ten patients with diabetic senile cataract and ten patients with nondiabetic senile cataract (control group) were included in this study. AOPP, MDA, and GSH levels and SOD activity were measured by a spectrophotometric method. Serum, lens Cu, and Zn levels were measured by an atomic absorption spectrophotometric method. Both the lens and serum Zn and Cu levels between the two groups were not significantly different (p > 0.05). GSH, AOPP, and MDA levels and the SOD activities in the diabetic senile cataract group were significantly increased as compared to the control group (p < 0.05). Oxidative stress is one of the major factors which may lead to the early cataract formation. Oxidative events are of great importance in diabetic complications and, particularly in the lens, may have a role in the pathogenesis of cataract associated with diabetes mellitus as exhibited in this study.

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Section: Discussionmentioning

confidence: 99%

The Evaluation of the Oxidative Stress Parameters in Nondiabetic and Diabetic Senile Cataract Patients

Yıldırım

Yildirim

Uçgun

et al. 2008

Biol Trace Elem Res

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“…Several population-based studies have found a higher prevalence of both nuclear and cortical opacities in women. [31][32][33] The association between education and cataract has also been one of the most consistently reported observations in the epidemiologic studies of cataract. 9,34 -37 Our study results suggest that low socioeconomic status is a risk factor for cataract.…”

Section: Types Of Cataract and Etiologymentioning

confidence: 99%

“…Partial relief of the condition by the administration of the antioxidant vitamin E and the iron-chelator deferoxamine 48,49 adds support to the idea that oxidative stress is imposed by smoke. The recent French Age-Related Eye Diseases (POLA) study 31 implicates the role of antioxidant enzymes in the etiology of PSC in lifelong heavy smokers.…”

Section: Mechanisms Of Smoke Actionmentioning

confidence: 99%

Smoking and Its Association with Cataract: Results of the Andhra Pradesh Eye Disease Study from India

Krishnaiah

Kovai

Shamanna

et al. 2005

Invest. Ophthalmol. Vis. Sci.

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“…Biologic measurements were made from fasting blood samples taken at the participant's home on the morning of the examination before usual medication intake. Coefficients of variation for measurements of plGPX and SOD were, respectively, 6% and 3% [36].…”

Section: Methodsmentioning

confidence: 98%

“…Therefore, all statistical analyses are based on 1224 subjects, among the 2193 (56 %) subjects free of clinical atherosclerosis. This research was approved by the ethics committee of the University Hospital of Montpellier, France and written informed consent was obtained from each participant [35], [36].…”

Section: Methodsmentioning

confidence: 99%

Retinal Vascular Caliber Is Associated with Cardiovascular Biomarkers of Oxidative Stress and Inflammation: The POLA Study

et al. 2013

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PurposeRetinal vascular caliber has been linked with increased cardiovascular risk and is predictive of cardiovascular pathology, including stroke and coronary heart disease. Oxidative stress, as well as inflammatory mechanisms, plays a major role in the pathogenesis and progression of atherosclerosis, plaque rupture and vascular thrombotic propensity. The purpose of this study is to explore the relationship between retinal vascular calibers and biomarkers of oxidative stress and inflammation, in subjects free of cardiovascular pathology.Patients and MethodsCross-sectional analysis from a community-dwelling cohort comprising 1224 individuals aged 60 years and over, without a history of coronary or peripheral artery disease or stroke. Retinal vascular caliber was measured from fundus photographs using semi-automated standardized imaging software. Oxidative stress was evaluated using plasma superoxide dismutase 2 and glutathione peroxidase (GPx-3) activities, and inflammatory state was assessed using plasma high sensitivity C-reactive protein (hsCRP) and orosomucoid.ResultsIn a multivariate model controlling for cardiovascular risk factors, larger retinal arteriolar caliber was independently related to higher level of GPx-3 activity (p = 0.003) whereas larger venular caliber was associated with higher levels of hsCRP (p = 0.0001) and orosomucoid (p = 0.01).ConclusionIn the present study, biomarkers of oxidative stress regulation and inflammation were independently associated with retinal vascular calibers. This suggests that an assessment of retinal vessels may offer early and non-invasive detection of subclinical vascular pathology.

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Associations of cataract with antioxidant enzymes and other risk factors

Cited by 44 publications

References 44 publications

The Evaluation of the Oxidative Stress Parameters in Nondiabetic and Diabetic Senile Cataract Patients

The Evaluation of the Oxidative Stress Parameters in Nondiabetic and Diabetic Senile Cataract Patients

Smoking and Its Association with Cataract: Results of the Andhra Pradesh Eye Disease Study from India

Retinal Vascular Caliber Is Associated with Cardiovascular Biomarkers of Oxidative Stress and Inflammation: The POLA Study

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