Associations of Cardiac Ventricular Repolarization with Serum Adhesion Molecules and Cognitive Function in Older Adults: The MIND-China Study

Wang, Chaoqun; Mao, Ming; Han, Xiaolei; Hou, Tingting; Wang, Xiaojie; Han, Qi; Dong, Yi; Li, Rui; Liu, Cong; Liu, Cuicui; Imahori, Yume; Vetrano, Davide Liborio; Wang, Yongxiang; Du, Yifeng; Qiu, Chengxuan

doi:10.3233/jad-220874

Cited by 4 publications

(12 citation statements)

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“…Publication bias analysis indicated that it would require 119 negative studies to negate the significance of this analysis. Another study was identified but could not be combined because it did not utilize MMSE 36 . Zonneveld et al.…”

Section: Resultsmentioning

confidence: 99%

“…36 Longer QT interval was significantly associated with lower global cognitive function and poorer executive function, "even among individuals without overt cardiovascular disease." 36 They did not appear to calculate QTc. 36 A qualitative analysis of the studies reviewed herein, identified several issues.…”

Section: Discussionmentioning

confidence: 99%

“…36 They did not appear to calculate QTc. 36 A qualitative analysis of the studies reviewed herein, identified several issues. First, each of these studies briefly defined their method for measurement of QT interval from a 12 lead ECG from the start of QRS complex to the end of the T wave.…”

Section: Discussionmentioning

confidence: 99%

“…Another study was identified but could not be combined because it did not utilize MMSE. 36 Zonneveld et al examined the relationship between QTc, calculated by the infrequently used Hodges formula, and correlated it with several measurements of cognitive function specifically the Stroop test, letter-digit coding test, and picture word learning tests. 37 Adjusting for cardiovascular risk factors in multivariable linear regression models, QTc was not associated with cognitive function while JTc was associated with cognitive function as assessed by the Stroop test.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Alzheimer dementia and QT interval: A meta‐analysis

Rabkin

2024

Aging Medicine

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While the link between aging and mortality from dementia is widely appreciated, the mechanism is not clear. The objective of this study was to determine whether there is a direct relationship between Alzheimer dementia (AD) and the QT interval, because the latter has been related to cardiac mortality. A systematic review and meta‐analysis were conducted after a Medline and EMBASE search using terms “Alzheimer disease or Dementia AND QT interval, QT dispersion or cardiac repolarization.” Four studies with control groups were identified. There were significant differences in QT interval between individuals with AD vs individuals without dementia (controls) (odds ratio (OR)1.665 [random effects model] and 1.879 [fixed effect model]) (p < 0.001). There were significant differences in QT interval between individuals with AD vs individuals with mild cognitive impairment (MCI) (OR 1.760 [random effects] and 1.810 [fixed effect]) (p < 0.001). A significant (p <0.001) correlation exists between the QTc and the Mini‐Mental State Exam (MMSE), a test of cognitive function. Two studies examined QT variability (the difference between the longest and shortest QT interval on a 12 lead ECG); the OR for QT variability AD vs MCI was 3.858 [random effects model] and 3.712 [fixed effects model] (p < 0.001). When compared to the control group, the OR for QT dispersion in AD was 6.358 [random effects model] or 5.143 ( P< 0.001) [fixed effects model]. A qualitative analysis of the data raised questions about paucity of data defining the nature of the control groups, the pathophysiologic mechanism, and the uniform use of a poor QT heart rate correction factor. The longer QT in AD, greater QT variability in AD, and the direct relationship between QT interval and AD severity supports a brain–heart connection in AD that might be fundamental to aging‐induced AD and mortality. Issues with defining the control group, limited number of studies, conflicting data in population studies, and the lack of a strong electrophysiological basis underscore the need for additional research in this field.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship between Alzheimer dementia and QT interval: A meta‐analysis

Rabkin

2024

Aging Medicine

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“…The 12-lead resting ECG was recorded by an electrocardiograph (CM300, COMEN, Shenzhen, China) and then analyzed by a physician. 16 APOE genotype was determined using a multiplex polymerase chain reaction amplification method, 1 and was dichotomized into carriers and noncarriers of the ε4 allele.…”

Section: Methodsmentioning

confidence: 99%

Strategic Lacunes Associated With Mild Cognitive Impairment in Rural Chinese Older Adults: A Population-Based Study

Wang,

Han,

et al. 2024

Stroke

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BACKGROUND: Lacunes are associated with cognitive impairment. We sought to identify strategic lacune locations associated with mild cognitive impairment (MCI) and subtypes of MCI among older adults, and further to examine the role of white matter hyperintensities and perivascular spaces in the association. METHODS: This population-based cross-sectional study included 1230 dementia-free participants in the brain magnetic resonance imaging substudy (2018–2020) in MIND-China (Multimodal Interventions to Delay Dementia and Disability in Rural China). Lacunes were visually identified in frontal lobe, parieto-occipital lobe, temporal lobe, insula, basal ganglia, thalamus, cerebellum, and brainstem. MCI, amnestic MCI (aMCI), and nonamnestic MCI (naMCI) were defined following the Petersen’s criteria. Data were analyzed using logistic regression models. RESULTS: Of the 1230 participants (age, ≥60 years; mean age, 69.40; SD, 4.30 years; 58.5% women), lacunes were detected in 357 people and MCI was defined in 286 individuals, including 243 with aMCI and 43 with naMCI. Lacunes in the supratentorial area, internal capsula, putamen/pallidum, and insula was significantly associated with increased odds ratio of MCI (multivariable-adjusted odds ratio ranged 1.40–3.21; P <0.05) and aMCI (multivariable-adjusted odds ratio ranged 1.46–3.36; P <0.05), whereas lacunes in the infratentorial area and brainstem were significantly associated with naMCI (multivariable-adjusted odds ratio ranged 2.68–3.46; P <0.01). Furthermore, the associations of lacunes in insula and internal capsula with MCI and aMCI, as well as the associations of lacunes in infratentorial area and brainstem with naMCI were present independent of white matter hyperintensities volume and perivascular spaces number. CONCLUSIONS: Lacunes in the internal capsula, putamen/pallidum, insula, and brainstem may represent the strategic lacunes that are independently associated with MCI, aMCI, or naMCI in Chinese older adults. REGISTRATION: URL: https://www.chictr.org.cn ; Unique identifier: ChiCTR1800017758.

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Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study

Ren,

Li,

Tian

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONTo examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)‐related plasma biomarkers among older adults.METHODSThis population‐based study included 5432 participants (age ≥60 years); of these, plasma amyloid beta (Aβ), total tau, and neurofilament light chain (NfL) were measured in a subsample (n = 1412). We used hierarchical clustering to generate five multimorbidity clusters from 23 chronic diseases. We diagnosed dementia and MCI following international criteria. Data were analyzed using logistic and linear regression models.RESULTSThe number of chronic diseases was associated with dementia (multivariable‐adjusted odds ratio = 1.22; 95% confidence interval [CI] = 1.11 to 1.33), AD (1.13; 1.01 to 1.26), vascular dementia (VaD) (1.44; 1.25 to 1.64), and non‐amnestic MCI (1.25; 1.13 to 1.37). Metabolic cluster was associated with VaD and non‐amnestic MCI, whereas degenerative ocular cluster was associated with AD (p < 0.05). The number of chronic diseases was associated with increased plasma Aβ and NfL (p < 0.05).DISCUSSIONMultimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD‐related plasma biomarkers in older adults.Highlights We used hierarchical clustering to generate five clusters of multimorbidity. The presence and load of multimorbidity were associated with dementia and mild cognitive impairment. Multimorbidity clusters were differentially associated with subtypes of dementia and Alzheimer's disease plasma biomarkers.

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Associations of Cardiac Ventricular Repolarization with Serum Adhesion Molecules and Cognitive Function in Older Adults: The MIND-China Study

Cited by 4 publications

References 39 publications

Relationship between Alzheimer dementia and QT interval: A meta‐analysis

Relationship between Alzheimer dementia and QT interval: A meta‐analysis

Strategic Lacunes Associated With Mild Cognitive Impairment in Rural Chinese Older Adults: A Population-Based Study

Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study

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