Associations of body mass index, waist circumference and waist-to-height ratio with cognitive impairment among Chinese older adults: Based on the CLHLS

Ren, Zheng; Li, Yuyu; Li, Xiangrong; Shi, Hong; Zhao, Hanfang; He, Minfu; Zha, Shuang; Qiao, Shanpeng; Pu, Yajiao; Liu, Hongjian; Zhang, Xiumin

doi:10.1016/j.jad.2021.08.093

Cited by 31 publications

(24 citation statements)

References 41 publications

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“…We found that a reverse J-shaped relationship of BMI with cognitive impairment was identified in the current research, suggesting that the BMI-defined statuses of overweight and obese could be related to a decreased risk of cognitive impairment and that the BMI-defined status of underweight could be related to an increased risk. The aforementioned findings were consistent with those from previous studies targeting a Chinese population [ 13 , 21 , 22 , 23 ]. For example, a Chinese cohort study, which included 12,027 individuals 65 years of age and older, found that a BMI-defined overweight status was related to a 16% decreased risk of cognitive impairment [ 22 ].…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, the Korean Longitudinal Study of Aging showed that older adults who are underweight may be at a higher risk for cognitive dysfunction [ 19 ]. A recent Chinese cohort study of 5156 subjects aged 75 and older reported an increased risk of cognitive impairment significantly associated with a BMI-defined status as underweight [ 23 ]. Several pathophysiological mechanisms may help explain our results.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous results suggested that a larger BMI and a BMI-defined overweight status were related to slower cognitive decline [ 13 ]. A cohort study reported that BMI-defined overweight status was associated with a lower risk of cognitive impairment [ 22 ], and another recent cohort study suggested that a BMI-defined underweight status was related to a higher risk of cognitive impairment [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Body Mass Index and Plant-Based Diet with Cognitive Impairment among Older Chinese Adults: A Prospective, Nationwide Cohort Study

Fang

Turner‐McGrievy

et al. 2022

Nutrients

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To examine the association of body mass index (BMI) and a plant-based diet (PBD) with cognitive impairment in older adults, this cohort study used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a national, community-based, longitudinal, prospective study in China. Cognitive function was evaluated via the Mini-Mental State Examination (MMSE). Diet was assessed using a simplified food frequency questionnaire (FFQ), and PBD patterns were estimated using the overall plant-based diet index (PDI), the healthful plant-based diet index (hPDI), and the unhealthful plant-based diet index (uPDI). BMI was measured objectively during the physical examination. Cox proportional hazard models and restricted cubic spline analyses were used. A total of 4792 participants with normal cognition at baseline were included, and 1077 participants were identified as having developed cognitive impairment during the 24,156 person-years of follow-up. A reverse J-shaped association was observed between BMI and cognitive impairment (p = 0.005 for nonlinearity). Participants who were overweight (HR = 0.79; 95% CI 0.66–0.95) and obese (HR = 0.72; 95% CI 0.54–0.96) had a decreased risk of cognitive impairment, while those who were underweight (HR = 1.42; 95% CI 1.21–1.66) had an increased risk. Lower PDI, lower hPDI, and higher uPDI were associated with an increased risk of cognitive impairment (HR = 1.32; 95% CI 1.16–1.50 for PDI; HR = 1.46; 95% CI 1.29–1.66 for hPDI; HR = 1.21; 95% CI 1.06–1.38 for uPDI). The protective effect of being overweight on cognitive impairment was more pronounced among participants with a higher PDI (HR = 0.74; 95% CI 0.57–0.95) than those with a lower PDI (HR = 0.87; 95% CI 0.67–1.12), among participants with a higher hPDI (HR = 0.73; 95% CI 0.57–0.94) than those with a lower hPDI (HR = 0.93; 95% CI 0.72–1.10), and among participants with a lower uPDI (HR = 0.61; 95% CI 0.46–0.80) than those with a higher uPDI (HR = 1.01; 95% CI 0.80–1.27). Our results support the positive associations of overweight status, obesity, an overall PBD, and a healthful PBD with cognitive function in older adults. A lower adherence to an overall PBD, a healthful PBD, and a higher adherence to an unhealthful PBD may attenuate the protective effect of being overweight on cognitive function.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Body Mass Index and Plant-Based Diet with Cognitive Impairment among Older Chinese Adults: A Prospective, Nationwide Cohort Study

Fang

Turner‐McGrievy

et al. 2022

Nutrients

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Section: Methodsmentioning

confidence: 99%

“…BMI was calculated as weight divided by height squared (kg/m 2 ). The height (in centimeter) and body weight (in kilogram) of participants were measured by interviewers during the survey (46). Continuous variables were summarized by mean ± standard deviation (SD) and categorical variables were summarized by numbers and percentage.…”

Section: Covariatesmentioning

confidence: 99%

Associations of Serum Albumin With Disability in Activities of Daily Living, Mobility and Objective Physical Functioning Regardless of Vitamin D: Cross-Sectional Findings From the Chinese Longitudinal Healthy Longevity Survey

et al. 2022

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ObjectiveTo examine the associations of serum albumin, a nutrition indicator, with disability in activities of daily living (ADL), mobility, and objective physical functioning among Chinese older adults.Materials and MethodsCross-sectional data of 2233 older adults (≥65 years) who participated in the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study was used. Serum albumin was measured by immunoturbidimetric assay. Physical functioning included subjectively (ADL and mobility) and objectively measured disability (standing up from a chair, picking up a book from the floor, and turning around 360°). Multivariable logistic regression models were performed.ResultsAfter adjusting for age and sex, compared with participants in the lowest quartile group of serum albumin, those in the highest quartile group had 45% lower odds of disability in ADL (odds ratio [OR]: 0.55; 95% confidence interval [CI]: 0.38, 0.80); 48% lower odds of disability in mobility (OR: 0.52; 95% CI: 0.38, 0.71); 46% lower odds of disability in standing up from a chair (OR: 0.54; 95% CI: 0.34, 0.85); and 37% lower odds of disability in picking up a book from the floor (OR: 0.63; 95% CI: 0.40, 0.97). We did not observe a statistically significant interaction effect between serum albumin and vitamin D on disability in physical functioning.ConclusionSerum albumin level was associated with physical functioning among Chinese older adults, regardless of vitamin D level. The findings indicate that appropriate management of poor nutritional status, in particular low serum albumin levels, may contribute to maintaining physical functioning in older adults.

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The Association between cognitive impairment and anthropometric indices among the elderly: birjand longitudinal aging study

Ramezani Kashal,

Nouredini,

Hezaveh

et al. 2024

J Diabetes Metab Disord

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Associations of body mass index, waist circumference and waist-to-height ratio with cognitive impairment among Chinese older adults: Based on the CLHLS

Cited by 31 publications

References 41 publications

Association of Body Mass Index and Plant-Based Diet with Cognitive Impairment among Older Chinese Adults: A Prospective, Nationwide Cohort Study

Association of Body Mass Index and Plant-Based Diet with Cognitive Impairment among Older Chinese Adults: A Prospective, Nationwide Cohort Study

Associations of Serum Albumin With Disability in Activities of Daily Living, Mobility and Objective Physical Functioning Regardless of Vitamin D: Cross-Sectional Findings From the Chinese Longitudinal Healthy Longevity Survey

The Association between cognitive impairment and anthropometric indices among the elderly: birjand longitudinal aging study

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