Associations of blood selenium and serum lipid levels in Japanese premenopausal and postmenopausal women

Karita, Kanae; Yamanouchi, Yasuko; Takano, Toshiya; Oku, Junji; Kisaki, Tomonari; Yano, Eiji

doi:10.1097/gme.0b013e31806bf32c

Cited by 34 publications

(25 citation statements)

References 28 publications

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“…They emphasised that serum Se levels could not reflect nutritional Se status in well-nourished humans because serum Se can easily reach a saturated level. In addition, they concluded that serum Se levels could only be useful as a nutritional status indicator in populations where Se intake is insufficient [21]. Because this mechanism may also be valid for Zn and Cu, future studies should evaluate both serum and erythrocyte levels of these trace elements to reveal the relationship of these trace elements to lipids and osteoporosis.…”

Section: Discussionmentioning

confidence: 94%

“…In addition, it has been shown that increased Se intake induces increased glutathione peroxidase activity and decreased concentrations of lipid parameters (TC, LDL-C, TG) in animal blood [56,66]. Karita et al [21] in their study reported that lower levels of Se in erythrocytes were associated with higher levels of serum TC and LDL-C and that this relationship was marked only in the postmenopausal group. However, in parallel with our results, they could not find any relation between serum Se level and lipids.…”

Section: Discussionmentioning

confidence: 95%

“…Karita et al [21] explained the reason for similar serum Se levels as being that serum Se reflects short-term Se status and fluctuates widely according to daily food intake. They emphasised that serum Se levels could not reflect nutritional Se status in well-nourished humans because serum Se can easily reach a saturated level.…”

Section: Discussionmentioning

confidence: 97%

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Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Arıkan

Coşkun

Özer

et al. 2011

Biol Trace Elem Res

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It has been shown that the trace elements and lipids play role in the growth, development and maintenance of bones. We aimed to investigate serum selenium (Se), zinc (Zn), copper (Cu) and lipid (total cholesterol, triglyceride (TG), high density lipoprotein-cholesterol, low-density lipoprotein-cholesterol) levels in postmenopausal women with osteoporosis, osteopenia and in healthy controls, and to determine the relationship between Se, Zn, Cu and lipid parameters and bone mineral density (BMD). The study included 107 postmenopausal women; 35 healthy (group 1), 37 osteopenic (group 2) and 35 osteoporotic (group 3). The women in all three groups were carefully matched for body mass index (BMI). Serum concentrations of Se, Zn and Cu were measured by atomic absorption spectrophotometry. Plasma Se, Cu, Zn and lipid levels were similar in all groups (p > 0.05). When we combined the women in each of the three groups, and considered them as one group (n = 107) we found a positive correlation between BMI and lumbar vertebra BMD, femur neck BMD, femur total BMD; a positive correlation between TG and femur neck BMD, femur total BMD; a positive correlation between Zn and lumbar vertebra BMD (total T score) (p < 0.05). There was no correlation between Se, Cu, Zn, P and lipid parameters (p > 0.05). Although BMI has a positive effect on BMD, trace elements and lipids, except Zn and TG, did not directly and correlatively influence BMD. Further studies are needed to clarify the role and relationship of trace elements and lipid parameters in postmenopausal osteoporosis.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

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Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Arıkan

Coşkun

Özer

et al. 2011

Biol Trace Elem Res

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“…Results from studies predicting heart disease using serum levels of selenium [22][23][24][25] have bee inconsistent. Serum selenium levels of diabetic patients were reported to be increased [30][31][32] decreased [33,34] or unchanged [35] compared to controls. Swapnil Rajpathak et al [20] have found that levels of selenium are lower among diabetic men with or without CVD than among healthy controls, In this study, by contrast between two groups of diabetic patient there is significant decrease in selenium level in group II(diabetic patients with CVD) than in group I(diabetic patients).…”

Section: Resultsmentioning

confidence: 99%

“…Positive relationships between serum selenium and total cholesterol concentrations are discussed in several studies of various serum selenium concentrations [2, 19,32,[36][37][38][39][40][41]43]. However, most participants have been young and middle-aged adults.…”

Section: ----------------------------------------mentioning

confidence: 99%

Evaluation of Changes in Levels of Serum Selenium in Diabetic Pateints and in Diabetic Pateints with Cardiovascular Disease

Kasar¹

2011

JNUS

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Selenium, an essential micronutrient, may affect several cardiometabolic risk factors, such as glucose homeostasis and lipid concentrations. The aim of this study is to examin the relation between serum selenium concentrations with serum lipids in diabetic patients and in diabetic patients with cardiovascular diseases (CVD).A case control study conducted in the National Diabetes Center, College of Medicine at Al-Mustansiryia University. Fasting glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C), HbA1c and Serum selenium were determine. Diabetes mellitus (n=256) divided into tow groups, group I (n=156) diabetic patients and group II (n=100) diabetic patients complicated with CVD. Normal healthy subjects were taken as control (n= 100).In the present study a significant decrease in selenium levels was found in patients groups compared to control also there is decrease in selenium levels of diabetic patients with CVD (group II) compared with diabetic patients (group I). These findings indicate that the decrease in serum selenium was associated with elevated serum concentrations of fasting blood glucose, total cholesterol, LDL-C, VLDL-C, triacylglycerols and duration of diabetes. In general despite their classification according to sex or diabetes type highly negative correlations (p<0.0001) were found with linear regression equations between fasting serum selenium concentration and HbA1c in patients group II. In conclusion the significant reductions in the level of selenium in diabetic patients may be response on the developing t he diabetic to anther disease like CVD.

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Selenium and lipid subfractions in Egyptian type 2 diabetes patients

Aboulsoud

2012

Comp Clin Pathol

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Associations of blood selenium and serum lipid levels in Japanese premenopausal and postmenopausal women

Abstract: E-Se may be one of the possible associated factors that decrease the levels of TC and LDL-C after menopause. Further studies are needed to clarify the cause-and-effect relationship of nutritional Se status and lipid profile.

Cited by 34 publications

References 28 publications

Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Evaluation of Changes in Levels of Serum Selenium in Diabetic Pateints and in Diabetic Pateints with Cardiovascular Disease

Selenium and lipid subfractions in Egyptian type 2 diabetes patients

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