Associations of Blood Lipid-Related Indices with Blood Pressure and Pulse Pressure in Middle-Aged Men

Wakabayashi, Ichiro

doi:10.1089/met.2014.0093

Cited by 18 publications

(22 citation statements)

References 43 publications

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“…In our study, hypertensive patients also had a significantly higher LAP compared to people without hypertension. This confirmed the results obtained on a bigger population by Wakabayashi [28], who studied over 36 000 middle-aged men. Zhong et al [27] suggest that reducing LAP has an anti-hypertensive effect on people with arterial hypertension.…”

Section: Discussionsupporting

confidence: 90%

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Rotter

Rył

Szylińska

et al. 2016

Exp Clin Endocrinol Diabetes

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Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT). Anthropometric measurements, including waist circumference and arterial pressure, were performed. We also determined the levels of fasting plasma glucose (FPG), total cholesterol (TC), high-density cholesterol (HDL), low-density cholesterol (LDL), triglyceride (TG), insulin, TT, SHBG, DHEAs, and E.Patients with diagnosed MetS, T2DM, HT, obesity, overweight and TDS had a significantly higher LAP compared to those without these conditions. LAP was significantly positively correlated with serum TC, FPG, insulin, DHEAs, as well as APB-systolic concentration, and negatively correlated with HDL, TT, and SHBG.LAP may then be used as a simple and inexpensive biomarker of metabolic disorders, and in risk assessment related to testosterone deficiency in aging men.

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Section: Discussionsupporting

confidence: 90%

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Rotter

Rył

Szylińska

et al. 2016

Exp Clin Endocrinol Diabetes

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“…Changes in the levels and pattern of antibodies to CIV may occur with time. 21 The atherogenic index of plasma (AIP) (log TG/HDL) is calculated in an attempt to predict cardiovascular risk. AIP is based on the ratio of the values of triglycerides to high-density lipoprotein (HDL) levels.…”

Section: Resultsmentioning

confidence: 99%

Relationship between Lipid Indices, Type IV Collagen Turnover and the Development of Microvascular Complications in Diabetic Patients with Arterial Hypertension

2019

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Background and aims: An important factor in the development of vascular wall lesions is the degradation of the major protein of connective tissue - type IV collagen. Type IV collagen peptides (CIVDP) derived from this degradation are present in the circulation and are a stimulus for production of anti-collagen type IV antibodies (ACIVAbs) IgM, IgG and IgA. The aim of this study was to find a possible association between ACIVAbs, lipid indices and the development of microvascular complications. Materials and methods: Sera of 93 patients (mean age 61.4±11.3 yrs, diabetes duration 9.88±3.12 yrs; hypertension duration 9.28±4.98) with type 2 diabetes mellitus (T2DM) and arterial hypertension (AH) were investigated. ACIVAbs was determined using ELISA and then compared to serum ACIVAbs in 42 age- and sex-matched controls. Diabetics were divided into two groups according to presence (group 1, n=67) or absence (group 2, n=26) of microangiopathy. Lipid profile and lipid indices (log TG/HDL, LDL/HDL, TC/HDL and TG/HDL) were examined too. Results: Patients with T2DM and AH showed statistically significant higher levels of serum ACIVAbs IgG than healthy controls [0.298 (0.237÷0.381) vs 0.210 (0.149÷0.262), KW=14.01, p<0.0001]. Group 1 had statistically significant higher levels of ACIVAbs IgG than patients without microangiopathy [0.323 (0.243÷0.391) vs 0.241 (0.207÷0.291), KW=7.66, p=0.006] and healthy controls [0.210 (0.149÷0.262), KW=17.52, p<0.0001). ACIVAbs IgG showed correlation with duration of diabetes (r=0.49, p=0.01), retinopathy (r=−0.20, p=0.04) and BMI (r=−0.24, p=0.05), HbA1c (r=0.21, p=0.04), SBP (r=0.16, p=0.05). ACIVAbs IgG correlated with log TG/HDL (r=0.21, p=0.01), LDL/HDL (r=0.19, p=0.02) TC/HDL (r=0.16, p=0.05) and with TG/HDL (r=0.15, p=0.05). Conclusion: Our study shows relationship between elevation of ACIVAbs IgG, high lipid indices and development of microvascular complications in patients with type 2 diabetes mellitus and arterial hypertension.

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“…The LAP, initially described by Kahn 7 , is a novel index of visceral adiposity that is based on WC and the fasting TG level. Previous studies indicated that the LAP reflects certain vascular risk factors, includeing DM 12 , IR 24 , and hypertension 25 . Wakabayashi and Daimon 12 identified a strong association between the LAP and DM in 10,170 Japanese subjects, and a study of 2,524 Chinese subjects demonstrated the stronger contribution to the IR index to the LAP than either BMI or WC.…”

Section: Discussionmentioning

confidence: 99%

Visceral adiposity index, lipid accumulation product and intracranial atherosclerotic stenosis in middle-aged and elderly Chinese

Cui

et al. 2017

Sci Rep

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We investigated the association of the newly established lipid accumulation product (LAP) and visceral adiposity index (VAI) with intracranial atherosclerotic stenosis (ICAS) in middle-aged and elderly Chinese. From June 2012 to January 2013, consecutive patients ≥40 years of age who underwent cerebral vascular imaging for various medical reasons were enrolled in this study. Multivariate logistic regression models were used to evaluate the correlation of VAI and LAP with the risk of ICAS. In total, 845 patients were included in the study. The prevalence of ICAS gradually increased in females and in all patients with advancing tertiles of VAI or LAP. After adjusting for potential risks, both the VAI and LAP were related to ICAS in females [VAI: odds ratio (OR) = 3.25, 95% confidence interval (95%CI) = 1.17–9.03, P = 0.024; LAP: OR = 4.11, 95%CI = 1.39–12.12, P = 0.011; tertiles 3 vs. 1]. The sensitivity, specificity, and positive predictive value (PPV) were 74.7%, 45.5%, and 84.4% for VAI (cut-off: 1.71) and 79.3%, 40.5%, and 84.1% for LAP (cut-off: 23.99). The same relationships in males were not significant. Both VAI and LAP were closely associated with an increased risk of ICAS in middle-aged and elderly Chinese females.

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Associations of Blood Lipid-Related Indices with Blood Pressure and Pulse Pressure in Middle-Aged Men

Abstract: LAP shows stronger associations with blood pressure and pulse pressure than the other lipid-related indices and is suggested to be better for discriminating the risk of hypertension.

Cited by 18 publications

References 43 publications

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Relationship between Lipid Indices, Type IV Collagen Turnover and the Development of Microvascular Complications in Diabetic Patients with Arterial Hypertension

Visceral adiposity index, lipid accumulation product and intracranial atherosclerotic stenosis in middle-aged and elderly Chinese

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