Associations of Blood Cadmium Levels With Depression and Lower Handgrip Strength in a Community-Dwelling Elderly Population: A Repeated-Measures Panel Study

Kim, Kyoung Nam; Lee, Mee Ri; Choi, Yoon-Hyeong; Lee, Bo Eun; Hong, Yun Chul

doi:10.1093/gerona/glw119

Cited by 29 publications

(16 citation statements)

References 40 publications

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“…The Q matrix was adapted from the analysis results obtained from Structure 2.2. The K matrix (kinship matrix) was obtained from the results of the relatedness analysis using SPAGeDi (Hardy and Vekemans, 2002 ). According to the correction method published by Benjamini and Hochberg ( 1995 ), a false discovery rate (FDR) of 0.05 was used as a threshold for significant associations.…”

Section: Methodsmentioning

confidence: 99%

QTL Detection and Elite Alleles Mining for Stigma Traits in Oryza sativa by Association Mapping

Dang

Liu

et al. 2016

Front. Plant Sci.

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Stigma traits are very important for hybrid seed production in Oryza sativa, which is a self-pollinated crop; however, the genetic mechanism controlling the traits is poorly understood. In this study, we investigated the phenotypic data of 227 accessions across 2 years and assessed their genotypic variation with 249 simple sequence repeat (SSR) markers. By combining phenotypic and genotypic data, a genome-wide association (GWA) map was generated. Large phenotypic variations in stigma length (STL), stigma brush-shaped part length (SBPL) and stigma non-brush-shaped part length (SNBPL) were found. Significant positive correlations were identified among stigma traits. In total, 2072 alleles were detected among 227 accessions, with an average of 8.3 alleles per SSR locus. GWA mapping detected 6 quantitative trait loci (QTLs) for the STL, 2 QTLs for the SBPL and 7 QTLs for the SNBPL. Eleven, 5, and 12 elite alleles were found for the STL, SBPL, and SNBPL, respectively. Optimal cross designs were predicted for improving the target traits. The detected genetic variation in stigma traits and QTLs provides helpful information for cloning candidate STL genes and breeding rice cultivars with longer STLs in the future.

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Section: Methodsmentioning

confidence: 99%

QTL Detection and Elite Alleles Mining for Stigma Traits in Oryza sativa by Association Mapping

Dang

Liu

et al. 2016

Front. Plant Sci.

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“…Korea is one of the fastest aging developed countries, and previous studies focusing on older adults in Korea have demonstrated significant relationships of handgrip strength with metabolic syndrome, osteoporosis, fracture, cognitive impairment, and depression [11,26,27,28]. However, little is known about the prospective relationship between handgrip strength and all-cause mortality in middle aged and older Korean adults.…”

Section: Introductionmentioning

confidence: 99%

Handgrip Strength and All-Cause Mortality in Middle-Aged and Older Koreans

Bae

Park

Sohn

et al. 2019

IJERPH

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Aging-related decline in handgrip strength has been associated with adverse functional and metabolic morbidity and mortality. Korea is one of the fastest aging countries, and the prospective relationship of handgrip strength with all-cause mortality in Korean adults has not been studied. We conducted a prospective observation study to examine whether baseline handgrip strength predicted mortality over eight years of follow-ups in Korean adults aged 45 years or older. We analyzed the nationwide survey data based on 9393 Korean adults (mean age of 61 ± 10.7 years) from the 2006–2014 Korean Longitudinal Study of Aging. The mean handgrip strength values measured using a dynamometer, and were divided into quartiles for each gender. Cox models were conducted in order to estimate the hazard ratios (HRs) of all-cause mortality with 95% confidence intervals (CIs) in relation to handgrip strength adjusting for covariates. There was a robust independent relationship between a weaker handgrip strength and higher all-cause mortality in both women and men, adjusting for selected covariates (e.g., age, income, smoking, exercise, and comorbidities). Compared to the strongest quartile (i.e., reference), women and men in the weakest group had higher HRs of mortality, 2.5 (95% CI: 1.7–3.8) vs. 2.6 (95% CI: 1.8–3.9), respectively. The robust independent relationships between weaker handgrip strength and higher all-cause mortality found in the study suggest that simply assessing and monitoring the handgrip strength during adulthood demonstrates great potentials for the public health of aging populations, and protects against premature death in Korean adults.

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“…Out of 473 records identi ed during the database search and 21 additional records identi ed after reference list search, a total of 16 entries [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] were included in the study. The ow-chart of the search process is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The strongest points proved to be the Representativeness of the sampleonly Laredo-Aguilera et al [27] did not receive a point, and the Based on design and analysis -Seino et al [29] and Olgun Yazar & Yazar [34] received 1 out of 2 points. [22] and Hand Grip Meter 6103, Tanita (1 study) [28] hand dynamometers. Three studies failed to include the names of the dynamometer models.…”

Section: Resultsmentioning

confidence: 99%

Association between Handgrip Strength and Depression in Older Adults - A Systematic Review and a Meta-Analysis

Zasadzka

Pieczyńska

Trzmiel

et al. 2021

Preprint

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Background: Depression remains an important health problem among older adults. Disorders in older age result from the accumulation of various factors, chief among them somatic diseases, stressful life events, social isolation, unfavorable social attitudes towards older people, declined cognitive function, malnutrition, polypharmacy. Depression may be associated with the deterioration of physical fitness, whose chief indicator is hand grip strength (HGS). The aim of the study was to investigate the relationship between depression and HGS among older populations using the available literature. Methods: PubMed, Web of Science and Science Direct databases were searched. The inclusion criteria were as follows: written in English and published after 2009, subject age: ³60 years, HGS measured using a hand dynamometer, assessment of the depressive symptoms using a validated tool. The following articles were excluded: studies conducted among institutionalized subjects and/or populations with a specific disease. Results: The total combined effect of 33 results presented in 16 studies included in the meta-analysis, converted to the correlation coefficient, was OEr =-.148(SE = .030, 95%CI:-.206 – -.091), indicating a weak, negative correlation between HGS and depressive symptoms. Conclusion: The review of the literature and the meta-analysis demonstrated a relationship between low muscle strength measured with the HGS test and intensified depressive symptoms in older populations. Bearing in mind that depression is often unrecognized or underdiagnosed among older patients, lowered muscle strength in older subjects, should be an important sign for physicians and physiotherapists and an incentive to screen them for depression.

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Associations of Blood Cadmium Levels With Depression and Lower Handgrip Strength in a Community-Dwelling Elderly Population: A Repeated-Measures Panel Study

Abstract: After adjusting for potential confounders, blood cadmium concentrations were associated with depression and lower handgrip strength in an elderly population. The participants' depressive status partially mediated the association between cadmium levels and handgrip strength.

Cited by 29 publications

References 40 publications

QTL Detection and Elite Alleles Mining for Stigma Traits in Oryza sativa by Association Mapping

QTL Detection and Elite Alleles Mining for Stigma Traits in Oryza sativa by Association Mapping

Handgrip Strength and All-Cause Mortality in Middle-Aged and Older Koreans

Association between Handgrip Strength and Depression in Older Adults - A Systematic Review and a Meta-Analysis

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