Associations of BDNF Genotype and Promoter Methylation with Acute and Long-Term Stroke Outcomes in an East Asian Cohort

Kim, Jae-Min; Stewart, Robert; Park, Man‐Seok; Kang, Hee‐Ju; Kim, Sung‐Wan; Shin, Il‐Seon; Kim, Hye‐Ran; Shin, Myung‐Geun; Cho, Ki-Hyun; Yoon, Jin‐Sang

doi:10.1371/journal.pone.0051280

Cited by 83 publications

(77 citation statements)

References 32 publications

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“…The role of epigenetics in post-stroke recovery has recently come to the fore with exciting findings [26–28]. Recent investigation suggests that microRNA (miRNA) play an important role in the molecular response to cerebral ischemia.…”

Section: Neuroplastic Changes Following Strokementioning

confidence: 99%

Early Rehabilitation After Stroke: a Narrative Review

Coleman

Moudgal

Lang

et al. 2017

Curr Atheroscler Rep

277

195

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Purpose of Review Despite current rehabilitative strategies, stroke remains a leading cause of disability in the USA. There is a window of enhanced neuroplasticity early after stroke, during which the brain’s dynamic response to injury is heightened and rehabilitation might be particularly effective. This review summarizes the evidence of the existence of this plastic window, and the evidence regarding safety and efficacy of early rehabilitative strategies for several stroke domain-specific deficits. Recent Findings Overall, trials of rehabilitation in the first 2 weeks after stroke are scarce. In the realm of very early mobilization, one large and one small trial found potential harm from mobilizing patients within the first 24 h after stroke, and only one small trial found benefit in doing so. For the upper extremity, constraint-induced movement therapy appears to have benefit when started within 2 weeks of stroke. Evidence for non-invasive brain stimulation in the acute period remains scant and inconclusive. For aphasia, the evidence is mixed, but intensive early therapy might be of benefit for patients with severe aphasia. Mirror therapy begun early after stroke shows promise for the alleviation of neglect. Novel approaches to treating dysphagia early after stroke appear promising, but the high rate of spontaneous improvement makes their benefit difficult to gauge. Summary The optimal time to begin rehabilitation after a stroke remains unsettled, though the evidence is mounting that for at least some deficits, initiation of rehabilitative strategies within the first 2 weeks of stroke is beneficial. Commencing intensive therapy in the first 24 h may be harmful.

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Section: Neuroplastic Changes Following Strokementioning

confidence: 99%

Early Rehabilitation After Stroke: a Narrative Review

Coleman

Moudgal

Lang

et al. 2017

Curr Atheroscler Rep

277

195

View full text Add to dashboard Cite

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“…This polymorphism has been shown to partially affect activity-dependent BDNF secretion by reducing BDNF secretion by 30% in Met/Met neurons in-vitro [90] and to impair motor skill acquisition in-vivo [78,79]. In patients with ischemic stroke, the Val66Met allele was associated with poor outcomes and physical disability after stroke, and with slower motor recovery [83,91–93]. Analysis of pathophysiological difference between Val and Met patients suggests that both can retain the ability to recovery after stroke; however, the rate and trajectory of recovery appears to be difference [94].…”

Section: Genetic Factorsmentioning

confidence: 99%

Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury

Alawieh

Zhao

Feng

2018

Behavioural Brain Research

145

111

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Neurological disorders are a major cause of chronic disability globally among which stroke is a leading cause of chronic disability. The advances in the medical management of stroke patients over the past decade have significantly reduced mortality, but at the same time increased numbers of disabled survivors. Unfortunately, this reduction in mortality was not paralleled by satisfactory therapeutics and rehabilitation strategies that can improve functional recovery of patients. Motor recovery after brain injury is a complex, dynamic, and multifactorial process in which an interplay among genetic, pathophysiologic, sociodemographic and therapeutic factors determines the overall recovery trajectory. Although stroke recovery is the most well-studied form of post-injury neuronal recovery, a thorough understanding of the pathophysiology and determinants affecting stroke recovery is still lacking. Understanding the different variables affecting brain recovery after stroke will not only provide an opportunity to develop therapeutic interventions but also allow for developing personalized platforms for patient stratification and prognosis. We aim to provide a narrative review of major determinants for post-stroke recovery and their implications in other forms of brain injury.

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“…Until now, few studies have focused on the genetics of initial neurological deficit, although studies at 2 and 4 weeks post stroke have reported an association between brain-derived neurotrophic factor (BDNF) and outcome. 33,34 Large efforts on studying genetic impact on early treatment effects of thrombolysis are underway. 40 Longer term prognosis on neurological/physical deficit can be grouped into neurological outcomes, stroke recurrence, and mortality.…”

Section: Neurological/physical Deficitmentioning

confidence: 99%