Associations of atopy and asthma during aging of an adult population over a 20-year follow-up

Ferreira, Diogenes S.; Kaushik, Sonia; Smith, Catherine L.; Dharmage, Shyamali C.; Benke, Geza; Thompson, Bruce; Walters, E. Haydn; Wolfe, Rory; Abramson, Michael J.

doi:10.1080/02770903.2017.1386669

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…FeNO, a surrogate biomarker for type2 airway inflammation, trend to diminish in elderly asthmatics [23,24]. Consistently, atopy inversely correlates with age and it could be speculated that airway neutrophilia may be sustained by a type1 and type3 immune response [25,26]. In particular, Th17 polarization could identify asthmatics with a peculiar phenotype: the frequent exacerbators as recently reported [27].…”

Section: Discussionsupporting

confidence: 55%

The impact of aging on outpatients with asthma in a real-world setting

Ciprandi

Schiavetti

Ricciardolo

2018

Respiratory Medicine

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Section: Discussionsupporting

confidence: 55%

The impact of aging on outpatients with asthma in a real-world setting

Ciprandi

Schiavetti

Ricciardolo

2018

Respiratory Medicine

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“…Increased smoking and allergy rates, severe air pollution and the aging population have all contributed to an annual rise in the incidence of asthma [3][4][5][6] . As indicated by epidemiological data from diverse countries, the prevalence of asthma ranges from 1% to 21%, and its incidence has increased by about 30% over the last two decades 7 .…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

et al. 2021

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An-Chuan Granule (ACG), a traditional Chinese medicine (TCM) formula, is an effective treatment for asthma but its pharmacological mechanism remains poorly understood. In this study, network pharmacology was applied to explore the potential mechanism of ACG in the treatment of asthma. The tumor necrosis factor (TNF), toll-like receptor (TLR), and Th17 cell differentiation-related, nucleotide-binding oligomerization domain (NOD)-like receptor, and NF-kappaB pathways were identified as the most significant signaling pathways involved in the therapeutic effect of ACG on asthma. A mouse asthma model was established using ovalbumin (OVA) to verify the effect of ACG and the underlying mechanism. The results showed that ACG treatment not only attenuated the clinical symptoms, but also reduced inflammatory cell infiltration, mucus secretion and MUC5AC production in lung tissue of asthmatic mice. In addition, ACG treatment notably decreased the inflammatory cell numbers in bronchoalveolar lavage fluid (BALF) and the levels of pro-inflammatory cytokines (including IL-6, IL-17, IL-23, TNF-alpha, IL-1beta and TGF-beta) in lung tissue of asthmatic mice. In addition, ACG treatment remarkably down-regulated the expression of TLR4, p-P65, NLRP3, Caspase-1 and adenosquamous carcinoma (ASC) in lung tissue. Further, ACG treatment decreased the expression of receptor-related orphan receptor (RORγt) in lung tissue but increased that of Forkhead box (Foxp3). In conclusion, the above results demonstrate that ACG alleviates the severity of asthma in a “multi-compound and multi-target” manner, which provides a basis for better understanding of the application of ACG in the treatment of asthma.

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“…Additionally, this investigation concentrated on adults and examined associations of combined asthma-atopy phenotypes with the proteome, two areas which have been underdiscussed in the literature. 10,28 Among our significant asthma findings, some have been associated with relevant respiratory outcomes. For example, IgE is a key immune and inflammation related molecule 29 and cysteinerich secretory protein LCCL domain-containing 2 (CRLD2) has been implicated with glucocorticoid response.…”

Section: Discussionmentioning

confidence: 90%

“…Examining plasma allowed for a whole‐body approach to disease characterization in a readily accessible tissue and illustration of physiologic differences between individuals with and without asthma. Additionally, this investigation concentrated on adults and examined associations of combined asthma‐atopy phenotypes with the proteome, two areas which have been underdiscussed in the literature 10,28 …”

Section: Discussionmentioning

confidence: 99%

Plasma protein signatures of adult asthma

Smilnak,

Lee,

Chattopadhyay

et al. 2024

Allergy

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BackgroundAdult asthma is complex and incompletely understood. Plasma proteomics is an evolving technique that can both generate biomarkers and provide insights into disease mechanisms. We aimed to identify plasma proteomic signatures of adult asthma.MethodsProtein abundance in plasma was measured in individuals from the Agricultural Lung Health Study (ALHS) (761 asthma, 1095 non‐case) and the Atherosclerosis Risk in Communities study (470 asthma, 10,669 non‐case) using the SOMAScan 5K array. Associations with asthma were estimated using covariate adjusted logistic regression and meta‐analyzed using inverse‐variance weighting. Additionally, in ALHS, we examined phenotypes based on both asthma and seroatopy (asthma with atopy (n = 207), asthma without atopy (n = 554), atopy without asthma (n = 147), compared to neither (n = 948)).ResultsMeta‐analysis of 4860 proteins identified 115 significantly (FDR<0.05) associated with asthma. Multiple signaling pathways related to airway inflammation and pulmonary injury were enriched (FDR<0.05) among these proteins. A proteomic score generated using machine learning provided predictive value for asthma (AUC = 0.77, 95% CI = 0.75–0.79 in training set; AUC = 0.72, 95% CI = 0.69–0.75 in validation set). Twenty proteins are targeted by approved or investigational drugs for asthma or other conditions, suggesting potential drug repurposing. The combined asthma‐atopy phenotype showed significant associations with 20 proteins, including five not identified in the overall asthma analysis.ConclusionThis first large‐scale proteomics study identified over 100 plasma proteins associated with current asthma in adults. In addition to validating previous associations, we identified many novel proteins that could inform development of diagnostic biomarkers and therapeutic targets in asthma management.

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Associations of atopy and asthma during aging of an adult population over a 20-year follow-up

Abstract: Atopy remains strongly associated with current asthma in 40 to 64 year-old adults, both prospectively and contemporaneously, but the prospective association is stronger.

Cited by 3 publications

References 28 publications

The impact of aging on outpatients with asthma in a real-world setting

The impact of aging on outpatients with asthma in a real-world setting

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

Plasma protein signatures of adult asthma

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