Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study

Horbal, Steven R.; Seffens, William; Davis, Adam R.; Silvestrov, Natalia; Gibbons, Gary H.; Quarells, Rakale C.; Bidulescu, Aurelian

doi:10.1093/ajh/hpw007

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…Clinical studies regarding the association between of 8-iso-PGF 2α levels and blood pressure or hypertension are scarce. 58,59 Higher plasma 8-iso-PGF 2α levels in the patients with resistant hypertension, as compared to wellcontrolled hypertensive patients, were reported by de Faria et al 17 The opposite results were yielded by the urine isoprostane studies. A positive association was established in the study of Horbal et al, whereas Melton et al, whilst measuring urine four F2-isoprostanes, established no prospective associations, neither for systolic nor diastolic blood pressure.…”

Section: Discussionmentioning

confidence: 94%

“…A positive association was established in the study of Horbal et al, whereas Melton et al, whilst measuring urine four F2-isoprostanes, established no prospective associations, neither for systolic nor diastolic blood pressure. 59,60 Oxidative stress may constitute a unifying link between psychological stress and hypertension, especially in the police officers, although this supposition still calls for further research to make it fully credible. It has also been proposed that oxidative stress amplifies blood pressure elevation in the presence of other prohypertensive factors whose clustering is encountered in the MetS subjects.…”

Section: Discussionmentioning

confidence: 99%

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The Associations of Perceived and Oxidative Stress with Hypertension in a Cohort of Police Officers

Janczura¹,

Rosa²,

Dropiński³

et al. 2021

DMSO

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

The Associations of Perceived and Oxidative Stress with Hypertension in a Cohort of Police Officers

Janczura¹,

Rosa²,

Dropiński³

et al. 2021

DMSO

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“…Our systematic search identified 8 studies that included 1693 adults (974 with hypertension) in Asia (3 studies), Europe (4 studies), and United States (1 study) (▶table 1) [19][20][21][22][23][24][25][26]. Most studies included middle-age adults, with 5 studies with a mean age ≥ 50 years.…”

Section: Search Results and Characteristics Of Included Studiesmentioning

confidence: 99%

Visfatin Level and The Risk of Hypertension and Cerebrovascular Accident: A Systematic Review and Meta-Analysis

Wang

et al. 2019

Horm Metab Res

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High blood pressure is related with increased cerebrovascular accident. High visfatin / NAMPT(nicotinamide phosphoribosyltransferase) plasma levels may promote vascular inflammation and atherosclerotic plaque destabilization and have been evaluated as a marker for identifying stages of essential hypertension. However, its role in the pathogenesis of hypertension and cerebrovascular accident (CVA) is still uncertain. In order to review and meta-analyze observational studies investigating visfatin concentration and the risk for hypertension or CVA, a systematic search of PubMed, ovid EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) until December 07, 2016 was performed. After data extraction and quality assessment, a meta-analysis was performed using RevMan 5.3 and STATA 14.0. A total of 1693 adults from 8 studies for hypertension (974 with hypertension) and 1696 adults from 7 CVA studies (957 with CVA) were enrolled in the current meta-analysis. Cochran’s Q-statistic and I2 test were applied to estimate the heterogeneity of the studies. The fixed-effects were used to compute the weighted mean difference in visfatin levels. Plasma visfatin concentration was much higher in hypertension and CVA patients than in healthy individuals. These evidences suggested the association of hypertension and CVA with higher plasma visfatin level.

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“…Dahl et al firstly reported that visfatin was markedly enhanced in symptomatic carotid atherosclerotic plaques [19]. Subsequently, various studies provided that visfatin was closely related with cardiovascular disease [20][21][22][23][24][25][26]. Horbal et al showd that the odds of severe hypertension were in accordance with the levels of visfatin [21].…”

Section: Discussionmentioning

confidence: 99%

Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction

Zheng

Lü

Ren

et al. 2020

BMC Cardiovasc Disord

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Background Visfatin is an adipokine that related with the inflammation in atherosclerosis and the destabilization of atherosclerotic plaque. The aim of this study was to observe the relationship between visfatin and major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients. Methods We enrolled a total of 238 patients (183 AMI and 55 control) who underwent coronary angiography. Patients with AMI were followed for an average of 19.3 months and 159 patients were finally included in the study. Results It was observed patients with AMI had higher serum visfatin levels than controls. The total incidence of MACEs was 11.32% (18/159) in AMI patients. After calculation of the Youden index, the best cut-off value of visfatin on the curve of receiver-operating characteristic was 8.799 ng/mL for predicting the occurrence of MACEs. The occurrence of MACEs was elevated in high-visfatin group (≥8.799 ng/mL) compared with low-visfatin group (≤8.799 ng/mL). The time to MACEs was correlated with visfatin (HR = 1.235, 95%CI 1.051–1.451, P = 0.01) and high-visfatin group had an earlier time to MACEs and a shorter time of cumulative survival. Conclusions Increased serum visfatin levels were observed in AMI patients, and correlated with an earlier onset and higher incidence of MACEs.

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Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study

Abstract: In our community sample of AA, there were increased odds of SH with increased levels of urinary 8-isoprostane and visfatin, but not with apelin.

Cited by 11 publications

References 18 publications

The Associations of Perceived and Oxidative Stress with Hypertension in a Cohort of Police Officers

The Associations of Perceived and Oxidative Stress with Hypertension in a Cohort of Police Officers

Visfatin Level and The Risk of Hypertension and Cerebrovascular Accident: A Systematic Review and Meta-Analysis

Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction

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