Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single nucleotide variants and hypercholesterolemia in the Polish population: a cross-sectional study

Abstract

The prevalence of hypercholesterolemia is estimated at about 60% in the adult Polish population and has remained stable in the last decades, contributing to increased cardiovascular mortality. 2,3 There are many genetic, environmental, and lifestyle risk factors for hyperlipidemia. Diet high in saturated fats, obesity, sedentary lifestyle, and smoking are all modifiable risk factors INTRODUCTION Hypercholesterolemia is a chronic noncommunicable disease caused by an imbalance in the plasma lipid profiles due to a fat metabolism disorder. 1 It is a well -known risk factor for atherosclerosis, which is closely associated with cardiovascular diseases (CVD), such as coronary artery disease (CAD), myocardial infarction (MI), cerebral stroke, or peripheral artery disease. 2