Associations of air PM2.5 level with gut microbiota in Chinese Han preschoolers and effect modification by oxytocin receptor gene polymorphism

Sun, Ying; Deng, Guozhe; Fan, Jinhui; Feng, Fulin; Ge, Qinyu; Shi, Yuan; Kang, Xuejun

doi:10.1016/j.envres.2022.114123

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…Interestingly, elevated levels of glucocorticoids have been observed in TRAP-exposed populations in China in two recent studies. 57 , 58 Associations were described here for exposure to PM although NO 2 exposure was not measured. Several studies suggest a potential link between exposure to TRAP and the activation of the hypothalamic–pituitary–adrenal axis (HPA) realizing glucocorticoids and inducing gut microbiome dysbiosis 57 , 59 , 60 which is in accordance with our observations.…”

Section: Resultsmentioning

confidence: 99%

Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways

Cheng,

Hedges,

Keski-Rahkonen

et al. 2024

Environ. Sci. Technol.

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This randomized crossover study investigated the metabolic and mRNA alterations associated with exposure to high and low traffic-related air pollution (TRAP) in 50 participants who were either healthy or were diagnosed with chronic pulmonary obstructive disease (COPD) or ischemic heart disease (IHD). For the first time, this study combined transcriptomics and serum metabolomics measured in the same participants over multiple time points (2 h before, and 2 and 24 h after exposure) and over two contrasted exposure regimes to identify potential multiomic modifications linked to TRAP exposure. With a multivariate normal model, we identified 78 metabolic features and 53 mRNA features associated with at least one TRAP exposure. Nitrogen dioxide (NO 2 ) emerged as the dominant pollutant, with 67 unique associated metabolomic features. Pathway analysis and annotation of metabolic features consistently indicated perturbations in the tryptophan metabolism associated with NO 2 exposure, particularly in the gut-microbiome-associated indole pathway. Conditional multiomics networks revealed complex and intricate mechanisms associated with TRAP exposure, with some effects persisting 24 h after exposure. Our findings indicate that exposure to TRAP can alter important physiological mechanisms even after a short-term exposure of a 2 h walk. We describe for the first time a potential link between NO 2 exposure and perturbation of the microbiome-related pathways.

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Section: Resultsmentioning

confidence: 99%

Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways

Cheng,

Hedges,

Keski-Rahkonen

et al. 2024

Environ. Sci. Technol.

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“…Although the A allele of rs53576 of the OXTR gene is likely related to a higher risk of developing mental disorders [160][161][162], the G allele carriers may be more susceptible to air pollution-related mental disorders. A previous study in 86 healthy Chinese preschoolers suggested that the G allele in OXTR rs53576 may be a risk factor for social impairment caused by PM 2.5 , with children with GG/GA genotypes being more susceptible than children with the AA genotype [73] (Table 1). Rs53576 polymorphism in the OXTR gene is found to be associated with striatal dopamine transporter availability in healthy subjects, and G carriers of this polymorphism could be more susceptible to environmental influences since the negative association of plasma oxytocin level with the striatal dopamine transporter availability was only observed in the G allele carriers of OXTR rs53576 [164].…”

Section: Susceptibility Biomarkersmentioning

confidence: 99%

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders

Bai,

Wang,

Liu

et al. 2024

Toxics

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Air pollution is one of the greatest environmental risks to health, with 99% of the world’s population living where the World Health Organization’s air quality guidelines were not met. In addition to the respiratory and cardiovascular systems, the brain is another potential target of air pollution. Population- and experiment-based studies have shown that air pollution may affect mental health through direct or indirect biological pathways. The evidence for mental hazards associated with air pollution has been well documented. However, previous reviews mainly focused on epidemiological associations of air pollution with some specific mental disorders or possible biological mechanisms. A systematic review is absent for early effect biomarkers for characterizing mental health hazards associated with ambient air pollution, which can be used for early warning of related mental disorders and identifying susceptible populations at high risk. This review summarizes possible biomarkers involved in oxidative stress, inflammation, and epigenetic changes linking air pollution and mental disorders, as well as genetic susceptibility biomarkers. These biomarkers may provide a better understanding of air pollution’s adverse effects on mental disorders and provide future research direction in this arena.

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“…These DNA adducts appear when guanine derivatives in the nuclear and mtDNA are oxidized. Fourteen studies reported a positive association between AP and markers of oxidative DNA damage, including 8-OHdG [20-22, 26, 30, 31, 38-41, 46-48, 53] and 8-oxodG [32,33,42,49,50,53].…”

Section: Early Effect Biomarkersmentioning

confidence: 99%

Early-life oxidative stress due to air pollution. A scoping review focusing on identifying potential ‘-OMICS’ biomarkers from body fluids

Coumans,

Al Jaaidi

2023

Environ. Res.: Health

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Exposure to air pollution (AP) is inevitable in daily life and an increasing number of epidemiological studies have reported that exposure to ambient particulate matter (PM) is associated with adverse health outcomes. Intrauterine, childhood, and adolescence are vulnerable periods, during which PM exposure can cause molecular changes, potentially leading to changes in metabolism and development. PM-induced oxidative stress is the underlying mechanism. Biomarkers can be used as illustrative measures of PM exposure to facilitate the assessment of potential health effects and provide a better understanding of the underlying mechanisms. The purpose of this scoping review is to report -OMICS biomarkers found in body fluids that are primarily related to oxidative stress and are already used to evaluate ambient AP exposure, as well as to identify knowledge gaps. Web of Science, PubMed, and Scopus databases were independently searched for all studies published between January 2013 and December 2022 that reported on -OMICS signature changes during pregnancy, childhood, and adolescence. Of the initial 757 articles, 36 met our inclusion criteria and reported on genomic, epigenomic, transcriptomic, proteomic, lipidomic, and metabolomic biomarkers. The findings of this scoping review indicate that exposure to various ambient pollutants in early life can cause oxidative stress. Integrating biomarkers from top-down -OMICS studies in an epidemiological context may provide a clear picture of the biomarker selection process to establish a causal relationship between PM exposure and disease pathogenesis. This knowledge could lead to the conceptualization and subsequent development of novel preventative strategies.

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Associations of air PM2.5 level with gut microbiota in Chinese Han preschoolers and effect modification by oxytocin receptor gene polymorphism

Cited by 6 publications

References 46 publications

Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways

Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways

Potential Early Effect Biomarkers for Ambient Air Pollution Related Mental Disorders

Early-life oxidative stress due to air pollution. A scoping review focusing on identifying potential ‘-OMICS’ biomarkers from body fluids

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