Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China

Abstract

BackgroundDespite of growing evidence on gastrointestinal comorbidities of rosacea, there was a lack of literatures regarding the role of diet on rosacea.ObjectivesTo investigate the relationship between adherence to a Mediterranean-like diet pattern and the risk of incident rosacea.MethodsThis was a prospective cohort study of government employees aged >20 years conducted between January 2018 and December 2021 from five cities of Hunan province of China. At baseline, participants completed a food frequency questionnaire and participated in a skin examination. Presence of rosacea was determined by certified dermatologists. Subsequent skin examinations during follow-up were performed every one-year interval since the entry of the study. The Mediterranean diet score (MDS) was generated based on seven food groups (whole grains, red meats, fish, raw vegetables, legumes, fruits and nuts). Binary logistic regression models adjusted for potential confounders were used to estimate risks for incident rosacea.ResultsOf the 3,773 participants who completed at least two consecutive skin examinations, 3,496 were eligible for primary analyses. With a total follow-up of 8,668 person-years, we identified 83 incident rosacea cases. After full adjustments for covariates, the MDS was associated a decreased risk of incident rosacea (aOR: 0.84, 95% CI: 0.72, 0.99; Ptrend = 0.037 for 1-point increment of MDS). In subgroup analyses by body mass index (BMI), this inverse association was consistently observed in the lowest and medium tertiles of BMI (<24.5 kg/m2), but not in the highest tertile of BMI (≥24.5 kg/m2), with a significant interaction effect (P < 0.001).ConclusionsOur results suggested that adherence to a Mediterranean-like diet pattern might reduce the risk of incident rosacea among non-overweight individuals.

Dietary Patterns in Acne and Rosacea Patients—A Controlled Study and Comprehensive Analysis

“…While the MD is generally known to be beneficial for health and conditions such as diabetes, cancer, and cardiovascular disease [42,43], the data from this study suggest additional advantageous effects on facial inflammatory dermatoses. This supports recent findings of a negative correlation between acne and the adherence to a MD [44], as well as a reduced incidence of rosacea with adherence to a MD [39]. Thus, adhering to a MD appears to be beneficial for both acne and rosacea.…”

“…The food items reported to be beneficial for both the AG and RG can be classified as a Mediterranean diet (MD), characterized by a high consumption of vegetables, legumes, oily fish, olive oil, nuts, and only moderate intake of meat, cheese, and alcohol [39][40][41]. While the MD is generally known to be beneficial for health and conditions such as diabetes, cancer, and cardiovascular disease [42,43], the data from this study suggest additional advantageous effects on facial inflammatory dermatoses.…”

Acne Vulgaris and adherence to the mediterranean diet among university students: a case‒control study

“…The MD is based on a regular intake of olive oil as the primary source of fat and high consumption of fruits, vegetables, and grains, while allowing a moderate intake of white meat, fish and wine, and restricting the consumption of sugary products and red meat [ 27 , 28 ]. Research has suggested that adherence to the MD may reduce the risk of cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome, dementia, rosacea, psoriasis, and hidradenitis suppurativa [ 29 – 35 ]. These health benefits have been attributed to the effects of the MD on insulin sensitivity, endothelial function, blood lipids, and inflammatory and oxidative stress [ 36 ].…”