Associations of accumulated exposure to persistent organic pollutants with serum lipids and obesity in an adult cohort from Southern Spain

Arrebola, Juan Pedro; Ocaña-Riola, Ricardo; Arrebola-Moreno, Antonio L.; Fernández-Rodríguez, María; Martín‐Olmedo, Piedad; Fernández, Mariana F.; Olea, Nicolás

doi:10.1016/j.envpol.2014.08.003

Cited by 67 publications

(43 citation statements)

References 56 publications

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“…18,31 To date, a particularly strong evidence has been accumulated supporting POPs as a risk factor for type 2 diabetes mellitus, insulin resistance, and obesity. [32][33][34][35][36] However, prospective population-based studies linking current exposures to different POPs and hypertension are still lacking. Further evidence on the role of certain POP, such as PCB, exposures on the risk of hypertension and CVD is needed.…”

Section: Donat-vargas Et Al Dietary Intake Of Pcbs and Hypertension 715mentioning

confidence: 99%

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

et al. 2015

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Polychlorinated biphenyls are persistent organic pollutants that are consumed because of their bioaccumulation through the food chain. Evidence from different sources suggests a positive association between polychlorinated biphenyls exposure and the incidence of hypertension. However, no previous prospective study has investigated this potential relationship in adults. We prospectively assessed the association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a large cohort. The Seguimiento Universidad de Navarra project is a Spanish cohort of university graduates, most of them health professionals. We included 14521 participants, initially free of hypertension, who were followed-up for a median of 8.3 years. Dietary intake of polychlorinated biphenyls was assessed at baseline through a previously validated 136-item semiquantitative food frequency questionnaire. The published concentration levels of polychlorinated biphenyls measured in samples of food consumed in Spain were used to estimate dietary intake. Multivariable Cox regression models were fitted to estimate hazard ratios and 95% confidence interval for incident hypertension. During follow-up, 1497 incident cases of medically diagnosed hypertension were identified. After adjusting for total energy intake and for potential confounders, participants in the fifth quintile of total polychlorinated biphenyls intake were at higher risk of developing hypertension (adjusted hazard ratio, 1.43 [95% confidence interval, 1.09–1.88; P for trend 0.017]) compared with those in the first quintile. In this Mediterranean cohort, dietary intake of polychlorinated biphenyls, estimated using a food frequency questionnaire, was associated with a higher risk of developing hypertension during follow-up. Nevertheless, further longitudinal studies are needed to confirm our results.

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Section: Donat-vargas Et Al Dietary Intake Of Pcbs and Hypertension 715mentioning

confidence: 99%

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

et al. 2015

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“…POPs are slow to degrade, and because of this, populations are still regularly exposed to them. In fact, POPs have been detected in virtually all human populations and ecosystem compartments [26] . POPs are highly lipophilic and biomagnify in the food chain [27] .…”

Section: Discussionmentioning

confidence: 99%

“…POPs are highly lipophilic and biomagnify in the food chain [27] . The main source of POP exposure among humans is diet, particularly fatty fish, breast milk, and fatty animal products, and once consumed, POPs accumulate in human adipose tissue where they can be stored or released for decades [26] .…”

Section: Discussionmentioning

confidence: 99%

Persistent Environmental Toxicants in Breast Milk and Rapid Infant Growth

Criswell¹,

Lenters²,

Mandal³

et al. 2017

Ann Nutr Metab

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Background/Aims: Many environmental toxicants are passed to infants in utero and through breast milk. Exposure to toxicants during the perinatal period can alter growth patterns, impairing growth or increasing obesity risk. Previous studies have focused on only a few toxicants at a time, which may confound results. We investigated levels of 26 toxicants in breast milk and their associations with rapid infant growth, a risk factor for later obesity. Methods: We used data from the Norwegian HUMIS study, a multi-center cohort of 2,606 mothers and newborns enrolled between 2002 and 2008. Milk samples collected 1 month after delivery from a subset of 789 women oversampled by overweight were analyzed for toxicants including polychlorinated biphenyls (PCBs), heavy metals, and pesticides. Growth was defined as change in weight-for-age z-score between 0 and 6 months among the HUMIS population, and rapid growth was defined as change in z-score above 0.67. We used a Bayesian variable selection method to determine the exposures that most explained variation in the outcome. Identified toxicants were included in logistic and linear regression models to estimate associations with growth, adjusting for maternal age, smoking, education, pre-pregnancy body mass index (BMI), gestational weight gain, parity, child sex, cumulative breastfeeding, birth weight, gestational age, and preterm status. Results: Of 789 infants, 19.2% displayed rapid growth. The median maternal age was 29.6 years, and the median pre-pregnancy BMI was 24.0 kg/m², with 45.3% of mothers overweight or obese. Rapid growers were more likely to be firstborn. Hexachlorobenzene, β-hexachlorocyclohexane (β-HCH), and PCB-74 were identified in the variable selection method. An interquartile range (IQR) increase in β-HCH exposure was associated with a lower odds of rapid growth (OR 0.63, 95% CI 0.42-0.94). Newborns exposed to high levels of β-HCH showed reduced infant growth (β = -0.03, 95% CI -0.05 to -0.01 for IQR increase in breast milk concentration). No other significant associations were found. Conclusions: Our results suggest that early life β-HCH exposure may be linked to slowed growth. Further research is warranted on the potential mechanism behind this association and the longer-term metabolic effects of perinatal β-HCH exposure.

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“…The associations between prenatal exposure to DDT and DDE and several measures of obesity were observed [94] Persistent organic pollutants: i.e. polychlorinated biphenyl 138 (PCB138); polychlorinated biphenyl 153 (PCB153); dichlorodiphenyldichloroethylene (p,p-DDE); hexachlorocyclohexane (β-HCH) cohort 298 adults PCB 138 was positively associated with BMI; HCB, p,p-DDE, and β-HCH showed quadratic associations with BMI [95] cadmium,PCBs,dioxins,p,p0-DDE and hexachlorobenzene (HCB) 114 children 7-9 years old Significant negative association was found in girls between prenatal cadmium exposure and weight, BMI and waist circumference (indicator of abdominal fat) and the sum of four skin folds (indicator of subcutaneous fat).…”

Section: +mentioning

confidence: 99%

“…Polychlorinated biphenyls (PCBs) with many industrial and commercial applications are also comprised of POPs [94].…”

Section: Persistent Organic Pollutants (Pops)mentioning

confidence: 99%

Are Environmental Contaminants Responsible for ‘Globesity’?

Filipiak‐Florkiewicz¹,

Topolska²,

Florkiewicz³

et al. 2017

Pol. J. Environ. Stud.

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Associations of accumulated exposure to persistent organic pollutants with serum lipids and obesity in an adult cohort from Southern Spain

Cited by 67 publications

References 56 publications

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

Persistent Environmental Toxicants in Breast Milk and Rapid Infant Growth

Are Environmental Contaminants Responsible for ‘Globesity’?

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