Associations between white matter microstructure and infants' working memory

Short, Steven A.; Elison, Jed T.; Goldman, Barbara Davis; Styner, Martin; Gu, Hongbin; Connelly, Mark; Maltbie, Eric; Woolson, Sandra; Lin, Weili; Gerig, Guido; Reznick, J. Steven; Gilmore, John H.

doi:10.1016/j.neuroimage.2012.09.021

Cited by 95 publications

(81 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FA and cognitive function relationships have been studied mainly in adults and older children (3,33), and some studies find lower RD in association with better cognition as an index of myelination (4,5). However, few studies have reported relationships between AD and cognition (1).…”

Section: Discussionmentioning

confidence: 99%

“…factor analysis | white matter | DTI | cognition | heritability I ndividual differences in white matter (WM) microstructure have been shown to be related to cognitive functions in adults (1,2) and children (3)(4)(5). Diffusion tensor imaging (DTI) parameters in different WM regions or tracts are variably associated with processing speed, general intelligence, and higher-order cognitive abilities (1)(2)(3)(4)(5).…”

mentioning

confidence: 99%

“…Diffusion tensor imaging (DTI) parameters in different WM regions or tracts are variably associated with processing speed, general intelligence, and higher-order cognitive abilities (1)(2)(3)(4)(5).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Lee

Steiner

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

Previous studies indicate that the microstructure of individual white matter (WM) tracts is related to cognitive function. More recent studies indicate that the microstructure of individual tracts is highly correlated and that a property common across WM is related to overall cognitive function in adults. However, little is known about whether these common WM properties exist in early childhood development or how they are related to cognitive development. In this study, we used diffusion tensor imaging (DTI) to investigate common underlying factors in 12 fiber tracts, their relationship with cognitive function, and their heritability in a longitudinal sample of healthy children at birth (n = 535), 1 y (n = 322), and 2 y (n = 244) of age. Our data show that, in neonates, there is a highly significant correlation between major WM tracts that decreases from birth to 2 y of age. Over the same period, the factor structure increases in complexity, from one factor at birth to three factors at age 2 y, which explain 50% of variance. The identified common factors of DTI metrics in each age group are significantly correlated with general cognitive scores and predict cognitive ability in later childhood. These factors are moderately heritable. These findings illustrate the anatomical differentiation of WM fiber from birth to 2 y of age that correlate with cognitive development. Our results also suggest that the common factor approach is an informative way to study WM development and its relationship with cognition and is a useful approach for future imaging genetic studies.factor analysis | white matter | DTI | cognition | heritability I ndividual differences in white matter (WM) microstructure have been shown to be related to cognitive functions in adults (1, 2) and children (3-5). Diffusion tensor imaging (DTI) parameters in different WM regions or tracts are variably associated with processing speed, general intelligence, and higher-order cognitive abilities (1-5).To date, the majority of DTI studies of WM microstructure have analyzed each tract or WM region independently. However, more recent studies clearly demonstrate that fractional anisotropy (FA) and other DTI metrics of WM microstructure correlate highly across WM tracts and across a wide age range, including neonates, older children, and adults (6-8). Furthermore, studies indicate that a general factor derived by principal component analyses (PCA) describing common variance in FA across WM tracts is associated with information processing speed (9) as well as general intelligence (10), at least in older adults. In children ages 8 to 16 y, three principal components of FA have been identified; the one corresponding to the corpus callosum was significantly related to IQ (11).The identification of one or more common WM factors that influence variation in multiple WM tracts or regions is important for several reasons. Such factors could prove to be a good target for imaging genetic studies, as one would expect genetic variants influencing WM development and function ...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Lee

Steiner

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Subtle interference in this lengthy interactive process generates individual differences and peculiarities within the normal range of human variation (2). However, more drastic developmental disturbances impose changes that will greatly modify adult brain circuits, with adverse consequences for cognition and behavior (3).…”

mentioning

confidence: 99%

Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum

Tovar‐Moll

Monteiro

Andrade

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

106

109

View full text Add to dashboard Cite

Why do humans born without the corpus callosum, the major interhemispheric commissure, lack the disconnection syndrome classically described in callosotomized patients? This paradox was discovered by Nobel laureate Roger Sperry in 1968, and has remained unsolved since then. To tackle the hypothesis that alternative neural pathways could explain this puzzle, we investigated patients with callosal dysgenesis using structural and functional neuroimaging, as well as neuropsychological assessments. We identified two anomalous white-matter tracts by deterministic and probabilistic tractography, and provide supporting resting-state functional neuroimaging and neuropsychological evidence for their functional role in preserved interhemispheric transfer of complex tactile information, such as object recognition. These compensatory pathways connect the homotopic posterior parietal cortical areas (Brodmann areas 39 and surroundings) via the posterior and anterior commissures. We propose that anomalous brain circuitry of callosal dysgenesis is determined by long-distance plasticity, a set of hardware changes occurring in the developing brain after pathological interference. So far unknown, these pathological changes somehow divert growing axons away from the dorsal midline, creating alternative tracts through the ventral forebrain and the dorsal midbrain midline, with partial compensatory effects to the interhemispheric transfer of cortical function.callosal agenesis | callosal plasticity | human connectome

show abstract

“…While fewer in number, investigations of the early neural structural correlates of poverty are emerging. As early differences in brain structure have been linked to cognitive development (73)(74)(75)(76)(77), elucidation of the neural effects of SES can inform regarding underlying mechanisms for altered neurocognitive performance, provide opportunities for targeted interventions, and perhaps drive policy change to reduce SES disparities (78,79).…”

Section: Poverty and The Brainmentioning

confidence: 99%

Effect of socioeconomic status disparity on child language and neural outcome: how early is early?

Hurt

Betancourt

2015

Pediatr Res

View full text Add to dashboard Cite

Associations between white matter microstructure and infants' working memory

Cited by 95 publications

References 88 publications

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum

Effect of socioeconomic status disparity on child language and neural outcome: how early is early?

Contact Info

Product

Resources

About