Associations between water iodine concentration and the prevalence of dyslipidemia in Chinese adults: A cross-sectional study

Wang, Dandan; Wan, Siyuan; Liu, Peng; Meng, Fengyan; Ren, Bingxuan; Qu, Mengying; Wu, Hui; Zhou, Zheng; Jin, Meihui; Shen, Hongmei; Liu, Lixiang

doi:10.1016/j.ecoenv.2020.111682

Cited by 10 publications

(12 citation statements)

References 21 publications

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“…Our finding suggests that high quality drinking water was associated with a lower risk of having dyslipidemia diagnosis in late adulthood after controlling for individual characteristics and neighborhood environments including community level of education, terrain, PM 2.5 , annual precipitation and temperature, and neighborhood GDP. This finding was in agreement with previous epidemiological studies that used state- or community-level data to find the detrimental impact of polluted water on blood lipoprotein [ 13 , 38 ]. Our result contributed to the literature in providing population-based evidence to confirm that drinking water quality can be a modifiable risk factor of dyslipidemia among older adults.…”

Section: Discussionsupporting

confidence: 92%

“…Obesity was determined by body mass index (BMI). BMI was defined as weight in kilograms divided by height in meters squared, and BMI ≥ 28 was categorized as obese [ 6 , 38 ]. To measure financial resources, we calculated annual household living expenditures.…”

Section: Methodsmentioning

confidence: 99%

“…We used the average annual PM 2.5 from 2000 to 2010 to capture the possibly delayed effect of air pollution on cognitive function [ 57 ]. The temperatures in January and July and annual precipitation were the average for 1981 to 2010 and were dichotomized to capture extreme weather conditions: annual total precipitation (> = 800 mm), temperatures in January (< -10 ◦ C/14 ◦ F) and July (≥ 28 ◦ C/82.4 ◦ F) [ 38 ]. Topography has been shown a key factor associated with water quality [ 58 , 59 ].…”

Section: Methodsmentioning

confidence: 99%

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Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS

Luo

Zhao

et al. 2022

BMC Geriatr

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Background The current study aimed to examine the association between drinking water quality and cognitive function and to identify the direct and indirect effects of drinking water quality and dyslipidemia on cognitive function among older adults in China. Methods Primary data for the study were selected from China Health and Retirement Longitudinal Study (CHARLS, 2015) and 4,951 respondents aged 60 and above were included. Data on drinking water quality were selected from the 2015 prefectural water quality data from the Institute of Public and Environment Affairs in China and measured by the Blue City Water Quality Index. Dyslipidemia was measured by self-reported dyslipidemia diagnosis and lipid panel. Three composite measures of cognitive function included mental status, episodic memory, and global cognition. Mixed effects models were conducted to assess the associations between drinking water quality or dyslipidemia and cognitive function. The mediation effects of dyslipidemia were examined by path analyses. Results Exposure to high quality drinking water was significantly associated with higher scores in mental status, episodic memory, and global cognition (β = 0.34, p < 0.001 for mental status; β = 0.24, p < 0.05 for episodic memory; β = 0.58, p < 0.01 for global cognition). Respondents who reported dyslipidemia diagnosis had higher scores in the three composite measures of cognitive function (β = 0.39, p < 0.001 for mental status; β = 0.27 p < 0.05 for episodic memory; β = 0.66, p < 0.001 for global cognition). An elevated blood triglycerides was only associated with higher scores in mental status (β = 0.21, p < 0.05). Self-reported dyslipidemia diagnosis was a suppressor, which increased the magnitude of the direct effect of drinking water quality on mental status, episodic memory, and global cognition. Conclusion Drinking water quality was associated with cognitive function in older Chinese and the relationship was independent of natural or socioeconomic variations in neighborhood environments. Improving drinking water quality could be a potential public health effort to delay the onset of cognitive impairment and prevent the dementia pandemic in older people.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS

Luo

Zhao

et al. 2022

BMC Geriatr

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“…Kelp, seaweed, shellfish, and sea shrimp contain more iodine, but their iodine concentration levels are different ( 15 ). Compared with food, the iodine in drinking water is easier to be absorbed and utilized, but the fluctuation of iodine content has a larger dynamic range (from 0.1 to 150 μg/L) ( 16 ), so people in areas with high-iodine–containing water are extremely susceptible to excessive iodine intake ( 17 ). In some western provinces, to maintain adequate iodine nutrition, iodized oil pills are used to supplement iodine, and iodine-contained multi-vitamin preparations have become a recommended measure by clinicians, especially for pregnant women.…”

Section: Introductionmentioning

confidence: 99%

The relationship between different iodine sources and nutrition in pregnant women and adults

Sun

Fan

et al. 2022

Front. Endocrinol.

Self Cite

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BackgroundDifferent iodine supplement measures emerge along with the economy development in China. The article objectives are to compare and explore the relationship between iodine sources and nutrition of pregnant women and adults.MethodsA total of 2,145 pregnant women and 1,660 adults were investigated by multi-stage random method. Questionnaire was used to collect basic information and the consumption of food, water, and iodine preparations. Household salt and individual urine and blood samples were collected, and thyroid function and morphology of pregnant women were measured.ResultsThe median urinary iodine concentration (MUIC) of pregnant women (164.49 μg/L) was lower than adults (187.30 μg/L, p < 0.05). Iodine supplement with IS (iodized salt) was the main measure for pregnant women and adults, and the difference was mainly on the consumption of iodine preparations between pregnant women (5.19%) and adults (0.85%). Moreover, adults’ dietary iodine intake from food (100.6 μg/day), IS (140.8 μg/day), and drinking water (6.0 μg/day) was higher than those of pregnant women (86.5, 107.2, and 3.5 μg/day, respectively). Compared with iodine supplement with IS, ISFP (IS + iodine-rich food + iodine preparations) could reduce the risk of iodine deficiency for pregnant women. The MUICs for pregnant women and adults of iodine supplements with IF (iodine-rich food) and ISF (IS + iodine-rich food) were lower. For pregnant women, thyroid nodule (11.90%) and peroxidase antibody (TPOAb) positive (9.32%) were high prevalent thyroid diseases, and habitation (urban/rural), gestation, annual income, and drinking water type would affect them.ConclusionPregnant women and adults had adequate iodine nutrition in four provinces. Their iodine supplement measures were different, the consumption of iodine preparations in pregnant women was higher, and their dietary iodine intake was lower than adults. ISFP was an effect measure for pregnant women to supplement iodine.

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“…Frozen plasma LDL-c, HDL-c, TG, and total TC from venous blood samples stored frozen at − 20 •C were analyzed by the Youanmen Center for Clinical Laboratory at Capital Medical University using the enzymatic colormetric test. The dyslipidemia was de ned based on the guidelines provided in the third report of the National Cholesterol Education Programme (NCEP) Adult Treatment Panel III (NCEP ATP III): TC ≥ 5.2 mmol/L; TG ≥ 1.7 mmol/L; HDL-C < 1.0 mmol/L in male and < 1.3 mmol/L in female; LDL-C ≥ 3.4 mmol/L [29].…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Individual and Combined Effect of Famine Exposure and Obesity Parameters on Dyslipidemia in Mid-Aged and Older Adult: A Population-Based Cross-Sectional Study

Zhang

Yang

Wang

et al. 2021

Preprint

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Background: Undernutrition in early life may have a lifelong effect on adult health. The associations between undernutrition and obesity parameters and dyslipidemia were inconsistent. The present study aimed to investigate the individual and combined effects of famine exposure and obesity parameters on dyslipidemia in middle-aged and older Chinese.Method: Data were selected from the China Health and Retirement Longitudinal Study Wave2011. The analytic sample included 9427 subjects aged 45 to 90. The present study analyzed data from 9427 middle-aged and older Chinese selected from the China Health and Retirement Longitudinal Study (CHARLS Wave2011). Differences between baseline characteristics and famine exposure/BMI levels/WC levels were evaluated using the Chi-square test, t-test, and F-test. Then, the difference in the prevalence of dyslipidemia between characteristic groups was also estimated by the Chi-square and t-test. Finally, multivariable-adjusted logistic regression models examined associations of famine exposure and obesity parameters with odds of prevalence of dyslipidemia.Results: Among the 9427 participants, 1097(11.64%) participants had been exposed to the Chinese famine during the fetal stage, whereas 3763(39.92%) participants and 3251(34.49%) participants had been exposed to the famine during childhood and adolescence/adult stage, respectively. Regarding the participants with BMI measurements,2771(29.39%) were overweight and 1105(11.72%) were obese, whereas 3955(41.95%) of the participants with WC measurements were obese, respectively. Furthermore, 1899(43.23%) reported having dyslipidemia in males and 1860(36.95%) in females. In multivariable-adjusted model, famine exposure and obesity parameters were associated with prevalence of dyslipidemia independently in total populations[(1) Model three c, famine exposure with prevalence of dyslipidemia: the fatal exposed vs no exposed group, 1.32 (95% CI 1.12, 1.56); childhood-exposed vs no exposed group, 1.49 (95% CI 1.30, 1.70); the adolescence/adult-exposed vs no exposed group, 1.49 (95%CI 1.30, 1.71) ; P for trend=0.000; (2) Model three e, famine exposure with prevalence of dyslipidemia: the fatal exposed vs no exposed group, 1.29 (95% CI 1 .09, 1.52); childhood-exposed vs no exposed group, 1.39 (95% CI 1.22, 1.59); the adolescence/adult-exposed vs no exposed group, 1.27 (95%CI 1.11, 1.46) ; P for trend=0.002; (3) Model three g, BMI levels with prevalence of dyslipidemia: overweight vs normal, 2.06 (95%CI 1.86, 2.27); obesity vs normal, 2.82(95% CI 2.42, 3.27); P for trend=0.000; (4) WC levels with prevalence of dyslipidemia: overweight vs normal, 2.24 (95% CI 2.05, 2.45)]. When stratified by sex, the results in females were mostly similar to those in the total population. In a multivariable logistic regression model three c, associations between famine exposure and dyslipidemia were not observed [fatal exposed group vs non-exposed group: 0.98 (95% CI 0.75, 1.28); childhood-exposed group vs non-exposed group: 0.96 (95% CI 0.78, 1.19); adolescence/adult exposed group vs non-exposed group: 0.86 (95% CI 0.69, 1.07)] independently of BMI only (P for trend =0.110). However, in a multivariable logistic regression model three e, associations between famine exposure and dyslipidemia in male were partly observed [fatal exposed group vs non-exposed group: 0.97 (95% CI 0.74, 1.26); childhood-exposed group vs non-exposed group: 0.91 (95% CI 0.74, 1.13); adolescence/adult exposed group vs non-exposed group: 0.73 (95% CI 0.59, 0.91)] independently of BMI only (P for trend =0.001). In general, the significant synergism between famine exposure and obesity parameters in lowering the prevalence of dyslipidemia was observed in males while the significant synergism in increasing prevalence of dyslipidemia was observed in females (P-interaction =0.000).Conclusion: Individual and combined associations of obesity parameters and famine exposure with the prevalence of dyslipidemia were observed in middle-aged and elderly Chinese.

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Associations between water iodine concentration and the prevalence of dyslipidemia in Chinese adults: A cross-sectional study

Cited by 10 publications

References 21 publications

Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS

Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS

The relationship between different iodine sources and nutrition in pregnant women and adults

Individual and Combined Effect of Famine Exposure and Obesity Parameters on Dyslipidemia in Mid-Aged and Older Adult: A Population-Based Cross-Sectional Study

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