Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis

Abstract

The aim of this study was to determine whether the vitamin D receptor (VDR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE). A meta-analysis was conducted on the associations between the BsmI, TaqI, FokI, and ApaI polymorphisms of VDR and RA or SLE using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) additive model. A total of ten studies, six RA and four SLE studies, were considered in the meta-analysis. Meta-analysis of the VDR BsmI and TaqI polymorphisms showed no association between RA in all subjects, or in European or Asian subjects. In contrast, meta-analysis of the F allele, the FF genotype, and the FF vs. the ff genotype of the FokI polymorphism showed significant associations with RA in Europeans. The overall OR of the association between the F allele and RA was 1.502 (95% CI=1.158-1.949, P=0.002). Meta-analysis of the B allele, BB+Bb genotype, and BB genotype (additive model) of the BsmI polymorphism showed significant associations with SLE and LN in Asians. The overall ORs of the associations between the B allele and SLE and LN were 3.584 (95% CI=1.407-9.130, P=0.007) and 3.652 (95% CI=1.347-9.902, P=0.011). This meta-analysis demonstrates that the VDR FokI polymorphism may confer susceptibility to RA in Europeans. Furthermore, associations were found between the VDR BsmI polymorphism and susceptibilities to SLE and LN in Asians.

Association between IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis

“…This disparity may have been caused by small sample sizes, low statistical power, ethnic variability between studies, and/or clinical heterogeneity. To overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood of random errors being responsible for false-positive or false-negative associations, we employed a meta-analysis approach [29][30][31]. Our aim in this study was to determine whether IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with RPL risk in different ethnicities.…”

PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

“…Individual studies based on small sample sizes have insufficient statistical power to detect positive associations and are incapable of demonstrating the absence of an association. To overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood of random errors causing false-positive or false-negative associations (Lee et al, 2007(Lee et al, , 2010(Lee et al, , 2011, we performed a meta-analysis to determine whether the PPARg Pro12Ala and His447His polymorphisms are associated with susceptibility to AD.…”

Lack of association of vitamin D receptor gene polymorphisms/haplotypes in Sjögren’s syndrome

“…These findings suggest that allelic variations of the VDR gene may partially represent a genetic component associated with the development of autoimmune diseases. Several studies have reported that genetic variations of VDR might be a risk factor for the development of autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS), psoriasis, autoimmune thyroid diseases (AITD), type I diabetes (T1D) [19][20][21][22][23][24][25].…”