Associations between visceral obesity and renal impairment in health checkup participants: a retrospective cohort study

Miyasato, Yoshikazu; Oba, Koji; Yasuno, Shinji; Matsuyama, Yutaka; Masuda, Izuru

doi:10.1007/s10157-020-01921-9

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…Brackets represent 95 % confidence intervals developing CKD [27]. A recent study by Miyasato et al suggested that visceral fat was the most sensitive obesity indicator for decline in kidney function [28]. However, a recent study showed that CT measures of obesity, such as visceral abdominal fat and subcutaneous adipose tissue, as well as BMI and WC were all significantly associated with kidney function decline, indicating that anthropometric measures of body fat such as BMI and WC appear to provide as consistent estimates of kidney function decline risk as CT measures [26].…”

Section: Discussionmentioning

confidence: 99%

The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study

et al. 2021

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Background It has been shown that individuals with obesity have a higher risk for chronic kidney disease (CKD). However, it is unclear which measure of obesity is most useful for prediction of CKD in the general population. The aim of this large prospective study was to explore the association between several anthropometric measures of obesity, i. e., body mass index (BMI), waist circumference (WC), waist circumference to height ratio (WHtR), waist-to-hip ratio (WHR), percentage of body fat (BF%), weight, height and incidence of hospitalizations due to CKD, in a population-based cohort study. Methods The ‘Malmö Diet and Cancer Study (MDCS)’ cohort in Sweden was examined during 1991 to 1996. A total of 28,449 subjects underwent measurement of anthropometric measures and blood pressure and filled out a questionnaire. Incidence of in- and outpatient hospital visits for CKD was monitored from the baseline examination over a mean follow-up of 18 years. Cox proportional hazards regression was used to explore the association between anthropometric measures and incidence of CKD, with adjustments for risk factors. Results The final study population included 26,723 subjects, 45-73 years old at baseline. Higher values of BMI, WC, WHR, WHtR and weight were associated with an increased risk of developing CKD in both men and women. Only in women, higher values of BF% was associated with higher risk of CKD. Comparing the 4th vs 1st quartile of the obesity measure, the highest hazard ratio (HR) for CKD in men was observed for BMI, HR 1.51 (95% CI: 1.18-1.94) and weight (HR 1.52 (95% CI: 1.19-1.94). For women the highest HR for CKD was observed for BF%, HR 2.01 (95% CI: 1.45-2.78). Conclusions In this large prospective study, all anthropometric measures of obesity were associated with a substantially increased incidence of CKD, except for BF% in men. Some measures were slightly more predictive for the risk of CKD than others such as BMI and weight in men and BF% in women. In clinical daily practice use of all anthropometric measures of obesity might be equally useful to assess the risk of developing CKD. This study supports the strong evidence for an association between obesity and CKD.

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Section: Discussionmentioning

confidence: 99%

The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study

et al. 2021

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“…After an overnight fast and urination, VFA was measured using the BIA (DUALSCAN HDS-2000, Omron Healthcare, Kyoto, Japan) according to the manufacturer's protocol. [24][25][26] Briefly, the device analyses weak electric currents passing through the body in order to obtain body impedance. In the analyzer, the hospital number, height, weight, age, and sex of each participant were entered.…”

Section: Measurements Of Vfamentioning

confidence: 99%

Lower Visceral Fat Area in Patients with Type 2 Diabetic Peripheral Neuropathy

Wu¹,

Wan²,

Xu³

et al. 2022

DMSO

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There is preliminary evidence that visceral fat area (VFA) was associated with the presence of type 2 diabetic peripheral neuropathy (DPN) in the Korean population; however, no studies have reported the association in Chinese population. The purpose of this study was to explore the possible correlation of VFA with DPN in such a population. Methods: A total of 2498 hospitalized patients with type 2 diabetes mellitus (T2DM) undergone VFA measurement, and were divided into DPN group (n=900) and non-DPN group (n=1594). The association of VFA with the presence of DPN was evaluated by correlation and multiple logistic regression analyses, generalized additive model with a smooth curve fitting, and receiver operating characteristic (ROC) curve analysis. Results:The VFA was significantly lower in the DPN group than in the non-DPN group (P < 0.001). VFA was significantly and positively associated with sural nerve conduction velocity (SNCV) and amplitude potential (SNAP) and negatively associated with the presence of DPN (all P< 0.001); there was no significant difference in the curve fitting (P = 0.344). Multivariate logistic regression analysis showed that the risk of presence of DPN decreased progressively across the VFA quartiles (P for trend < 0.001) and was significantly lower in patients in the highest VFA quartile than in those in the lowest quartile (OR: 0.382, 95% CI 0.151-0.968, P< 0.001) after multivariate adjustment. The ROC analysis revealed that the best cut-off value of VFA for predicting the presence of DPN was 50.5cm 2 (sensitivity 84.40%; specificity 34.00%). Conclusion: These results suggest that lower VFA level may be associated with increased risk of the presence of DPN in T2DM patients.

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“…34,35 Especially excess visceral fat, compared with subcutaneous, has been associated with a higher kidney risk. [36][37][38][39] For this study, mGFR was indexed for BSA. Indexing for BSA is a common practice to account for body size, a factor known to influence kidney function.…”

Section: Discussionmentioning

confidence: 99%

Central Body Fat Distribution and Kidney Function after Living Kidney Donation

Westenberg,

Pol,

van der Weijden

et al. 2024

CJASN

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Background: In most screening guidelines, high body mass index (BMI) is considered a contraindication for kidney donation. New insights suggest that central body fat distribution might provide greater power in assessing kidney risk. This study aimed to determine if BMI and central body fat distribution measures are associated with long-term kidney function after donor nephrectomy. We hypothesized that higher BMI, waist circumference, and waist-to-height ratio were associated with lower kidney function long-term after donation. Methods: The study population consisted of living kidney donors. BMI, waist circumference, and waist-to-height ratio were measured during donor screening. The outcome post-donation kidney function was assessed using measured glomerular filtration rate (measured GFR, 125I-Iothalamate infusion) at 3 months (n=1042), 5 years (n=556) and 10 years (n=210) follow-up. Primary multivariable linear regression analyses were performed with BMI and waist circumference; secondary analyses with waist-to-height ratio. Linear mixed models were performed to investigate change in post-donation estimated GFR. Results: Donor age was 52±11 years, and 48% were male. Mean BMI was 26.1±3.6 kg/m2 and waist circumference was 91±11 cm. Higher pre-donation BMI was associated with lower measured GFR throughout follow-up: -1.35 (95% CI -1.95; -0.80), -1.55 (95% CI -2.50; -0.65), and -2.35 (95% CI -4.10; -0.60) mL/min/m2 per 5 kg/m2 higher BMI at 3 months, 5 years, and 10 years after donation, respectively, adjusted for sex, age, and pre-donation GFR. For waist circumference, differences in measured GFR were -1.30 (95% CI -1.70; -0.90), -1.50 (95% CI -2.20; -0.80), and -1.70 (95% CI -3.00- -0.50) mL/min/m2 per 10 cm higher waist circumference at 3 months, 5 years, and 10 years after donation, respectively. In male donors, BMI and waist circumference were significantly associated with a negative post-donation change in estimated GFR. Conclusions: Higher BMI and waist circumference were independently associated with lower GFR (long-term) after living kidney donation.

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Associations between visceral obesity and renal impairment in health checkup participants: a retrospective cohort study

Cited by 7 publications

References 34 publications

The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study

The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study

Lower Visceral Fat Area in Patients with Type 2 Diabetic Peripheral Neuropathy

Central Body Fat Distribution and Kidney Function after Living Kidney Donation

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