Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men

Gautier, A; Bonnet, Fabrice; Dubois, Séverine; Massart, Catherine; Grosheny, C.; Bachelot, Anne; Aubé, Christophe; Balkau, Beverley; Ducluzeau, Pierre-Henri

doi:10.1111/j.1365-2265.2012.04401.x

Cited by 68 publications

(67 citation statements)

References 36 publications

(52 reference statements)

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“…The associations between smoking, BMI and hormone levels in the present study are supported by previous findings 25 26. Smoking is a well-known risk factor for RA,27 and a recent case–control study demonstrated an association between low BMI and seronegative RA in men 28.…”

Section: Discussionsupporting

confidence: 91%

Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case–control study

et al. 2013

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Section: Discussionsupporting

confidence: 91%

Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case–control study

et al. 2013

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“…An age-related elevation in estradiol may be due to increased aromatization in adipose tissue (Gautier et al 2013). We also found increased estradiol in males of both ages after sexual behavior.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in sexual function and steroid-hormone receptors in the medial preoptic area of male rats

Nutsch

Will

Tobiansky

et al. 2017

Hormones and Behavior

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Testosterone is the main circulating steroid hormone in males, and acts to facilitate sexual behavior via both reduction to dihydrotestosterone (DHT) and aromatization to estradiol. The mPOA is a key site involved in mediating actions of androgens and estrogens in the control of masculine sexual behavior, but the respective roles of these hormones is not fully understood. As males age they show impairments in sexual function, and a decreased facilitation of behavior by steroid hormones compared to younger animals. We hypothesized that an anatomical substrate for these behavioral changes is a decline in expression and/or activation of hormone receptor-sensitive cells in the mPOA. We tested this by quantifying and comparing numbers of AR- and ERα-containing cells, and Fos as a marker of activated neurons, in the mPOA of mature (4-5 months) and aged (12-13 months) male rats, assessed one hour after copulation to one ejaculation. Numbers of AR- and ERα cells did not change with age or after sex, but the percentage of AR- and ERα-cells that co-expressed Fos were significantly up-regulated by sex, independent of age. Age effects were found for the percentage of Fos cells that co-expressed ERα (up-regulated in the central mPOA) and the percentage of Fos cells co-expressing AR in the posterior mPOA. Interestingly, serum estradiol concentrations positively correlated with intromission latency in aged but not mature animals. These data show that the aging male brain continues to have high expression and activation of both AR and ERα in the mPOA with copulation, raises the possibility that differences in relationships between hormones, behavior, and neural activation may underlie some age-related impairments.

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“…In this respect, a significant but negative correlation was found between WC and testosterone. Similarly, the significant inverse association between plasma levels of cytokines and testosterone suggests an important role of low-grade visceral fat inflammation in the testosterone deficiency (19).…”

Section: Discussionmentioning

confidence: 99%

A short-term arm-crank exercise program improved testosterone deficiency in adults with chronic spinal cord injury

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To determine the influence of arm-crank exercise in reproductive hormone levels in adults with chronic SCI. Further objectives were to assess the influence of arm-crank exercise on muscle strength and body composition. Materials and Methods: Seventeen male adults with complete SCI at or below the 5th thoracic level (T5) volunteered for this study. Participants were randomly allocated to the intervention (n = 9) or control group (n = 8) using a concealed method. The participants in the intervention group performed a 12-week arm-crank exercise program, 3 sessions/week, consisting of warming-up (10-15 min) followed by a main part in arm--crank (20-30 min [increasing 2 min and 30 seconds each three weeks]) at a moderate work intensity of 50-65% of heart rate reserve (HRR) (starting at 50% and increasing 5% each three weeks) and by a cooling-down period (5-10 min). Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and estradiol were determined by ELISA. Muscle strength (handgrip) and body composition (waist circumference [WC]) were assessed. Results: After the completion of the training program, testosterone level was significantly increased (p = 0.0166;d = 1.14). Furthermore, maximal handgrip and WC were significantly improved. Lastly, a significant inverse correlation was found between WC and testosterone (r =-0.35; p = 0.0377). Conclusion:The arm-crank exercise improved reproductive hormone profile by increasing testosterone levels in adults with chronic SCI. A secondary finding was that it also significantly improved muscle strength and body composition in this group.

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Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men

Cited by 68 publications

References 36 publications

Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case–control study

Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case–control study

Age-related changes in sexual function and steroid-hormone receptors in the medial preoptic area of male rats

A short-term arm-crank exercise program improved testosterone deficiency in adults with chronic spinal cord injury

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