Associations between traditional and non-traditional anthropometric indices and cardiometabolic risk factors among inpatients with type 2 diabetes mellitus: a cross-sectional study

Golabi, Sahar; Ajloo, Sajad; Maghsoudi, Fatemeh; Adelipour, Maryam; Naghashpour, Mahshid

doi:10.1177/03000605211049960

Cited by 9 publications

(7 citation statements)

References 53 publications

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“…An increased CMI poses a risk for individuals with T2DM and is recognized as a detrimental factor. To effectively prevent the onset of T2DM, appropriate measures should be implemented to mitigate the escalation of the CMI from low to high values [ 15 , 16 ]. Additionally, the CMI exhibited positive correlations with diastolic blood pressure, systolic blood pressure, BMI, hip circumference, glucose (at 0 min), insulin (at 0 min), insulin (at 120 min), HOMA-IR, TC and PWV values.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the cardiometabolic index and arteriosclerosis in patients with type 2 diabetes mellitus

Tang,

Pang,

Dang

et al. 2024

BMC Cardiovasc Disord

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Background The cardiometabolic index (CMI) is a new metric derived from the triglyceride-glucose index and body mass index and is considered a potential marker for cardiovascular risk assessment. This study aimed to examine the correlation between the CMI and the presence and severity of arteriosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods This study involved 2243 patients with T2DM. The CMI was derived by dividing the triglyceride level (mmol/L) by the high-density lipoprotein level (mmol/L) and then multiplying the quotient by the waist-to-height ratio. Multivariate logistic regression was used to analyze the correlations between the CMI and BMI blood biomarkers, blood pressure, and brachial-ankle pulse wave velocity (baPWV). Results Patients were categorized into three groups based on their CMI: Group C1 (CMI < 0.775; n = 750), Group C2 (CMI: 0.775–1.355; n = 743), and Group C3 (CMI > 1.355; n = 750). Increased BMI, fasting glucose, insulin (at 120 min), total cholesterol (TC), and baPWV values were observed in Groups C2 and C3, with statistically significant trends (all trends P < 0.05). The CMI was positively correlated with systolic blood pressure (r = 0.74, P < 0.001). Multivariate analysis revealed that an increased CMI contributed to a greater risk for arteriosclerosis (OR = 1.87, 95%CI: 1.66–2.10, P < 0.001). Compared to the C1 group, the C2 group and C3 group had a greater risk of developing arteriosclerosis, with ORs of 4.55 (95%CI: 3.57–5.81, P<0.001) and 5.56 (95%CI: 4.32–7.17, P<0.001), respectively. The association was notably stronger in patients with a BMI below 21.62 kg/m² than in those with a BMI of 21.62 kg/m² or higher (OR = 4.53 vs. OR = 1.59). Conclusions These findings suggest that the CMI is a relevant and independent marker of arteriosclerosis in patients with T2DM and may be useful in the risk stratification and management of these patients.

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Section: Discussionmentioning

confidence: 99%

Correlation between the cardiometabolic index and arteriosclerosis in patients with type 2 diabetes mellitus

Tang,

Pang,

Dang

et al. 2024

BMC Cardiovasc Disord

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“…VAI, CVAI, TyG, and LAP are common obesity- and lipid-related indices that reflect the distribution of fat and indirectly glyco-metabolic ( 48 , 49 ). Our study also found that these indices are also sensitive predictors of hypogonadism in Chinese males with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Combined obesity- and lipid-related indices are associated with hypogonadism in Chinese male patients with type 2 diabetes: a cross-sectional study

Yu,

Wang,

et al. 2024

Front. Endocrinol.

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BackgroundThere is insufficient attention to hypogonadism in Chinese males with type 2 diabetes mellitus (T2DM). We evaluated the relationship between Combined obesity- and lipid-related indices [Visceral Adiposity Index (VAI), Chinese Visceral Adiposity Index (CVAI), Triglyceride Glucose Index (TyG) and Lipid Accumulation Product (LAP)] with total testosterone (TT) and analyzed the predictive capability of the respective cut-off values.MethodsWe recruited 958 hospitalized male patients with T2DM at the Affiliated Hospital of Qingdao University, collected baseline data and four calculated indices, and obtained their dominance ratio (OR) and corresponding 95% confidence intervals (CI) with TT by multivariate logistic regression. Receiver operating characteristic (ROC) curves were then used to determine cutoff values in predicting hypogonadism (TT< 12 nmol/L), and we also analyzed the combinations between the different indices.ResultsVAI, CVAI, TyG, and LAP all have satisfactory predictive capabilities. The test capability (sensitivity and specificity) of all four indices was better or not worse than that of body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and waist circumference (WC). All four indices were effective predictors of hypogonadism at their respective cutoff values (VAI ≥ 2.284, CVAI ≥ 145.779, TyG ≥ 4.308, and LAP ≥ 59.850). Of these, LAP had the largest area under the curve (AUC, AUC = 0.852, Std. Error = 0.014, 95% CI = 0.818-0.873). However, the predictive capability of the combined indices was not significantly improved over the individual indices.ConclusionsVAI, CVAI, TyG, and LAP are sensitive indices for predicting hypogonadism in Chinese male patients with T2DM. Considering the need for concise and accurate indices in clinical practice, we suggest LAP as a commonly used index.

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“…Obesity is a worldwide epidemic and leads to a 20% increased risk of acute myocardial infarction and obesity plays a major role in the development of T2DM. T2DM is a major risk factor for cardiovascular disease (20). Visceral obesity has been proven to be a more critical risk factor for T2DM (21).…”

Section: Discussionmentioning

confidence: 99%

“…Visceral adiposity index and LAP levels are very efficient in predicting cardiovascular disease risk factors in various clinical studies (20)(21)(22)(29)(30)(31). In people with T2DM and visceral obesity, lipid and lipoprotein metabolism problems are common, resulting in diabetic dyslipidemia and a high risk of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Tip 2 Diyabetli Bireylerde Aterojenik Plazma İndeksi ile İlişkili Visseral Adipozite İndekslerinin Değerlendirilmesi

Yılmaz

Özçıçek

Mertoğlu

et al. 2022

Düzce Tıp Fakültesi Dergisi

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Aim: This study was aimed to investigate visceral adiposity indicators and the atherogenic index of plasma (AIP) in type 2 diabetes mellitus (T2DM) patients. Material and Methods: A total of 353 adults aged between 18 and 74 years were included in this study. Bodyweight, height, waist, and hip circumference were measured; fasting blood glucose, HbA1c, and lipid profile (total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) values were analyzed. Visceral adiposity index (VAI), lipid accumulation product (LAP), body adiposity index (BAI), body shape index (ABSI), body roundness index (BRI), conicity index (CI), and AIP levels were calculated. Results:The study included 116 (32.9%) males and 237 (67.1%) females, with a mean age of 57.8±11.5 years. AIP z-scores were found to be directly related to T2DM (OR, 5.03; 95% CI: 1.95-13.01), while VAI z-scores were less associated with T2DM (OR, 1.10; 95% CI: 1.03-1.18). According to the ROC curve analysis, although the area under the curve (AUC) is weak to distinguish diabetic patients with VAI, LAP, and AIP, it is statistically significant (p<0.

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Associations between traditional and non-traditional anthropometric indices and cardiometabolic risk factors among inpatients with type 2 diabetes mellitus: a cross-sectional study

Cited by 9 publications

References 53 publications

Correlation between the cardiometabolic index and arteriosclerosis in patients with type 2 diabetes mellitus

Correlation between the cardiometabolic index and arteriosclerosis in patients with type 2 diabetes mellitus

Combined obesity- and lipid-related indices are associated with hypogonadism in Chinese male patients with type 2 diabetes: a cross-sectional study

Tip 2 Diyabetli Bireylerde Aterojenik Plazma İndeksi ile İlişkili Visseral Adipozite İndekslerinin Değerlendirilmesi

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