Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Kanu, Joseph Sam; Qiu, Shuang; Yi, Cheng; Li, Ri; Kou, Changgui; Gu, Yan; Bai, Yang; Shi, Jingwei; Li, Yong; Liu, Yunkai; Yu, Yaqin; Liu, Yawen

doi:10.1186/s12944-018-0767-8

Cited by 16 publications

(16 citation statements)

References 68 publications

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“…The results of meta-analysis revealed a number of contradictions with regard to associations of the rs266729 SNP and cardiovascular morbidity [7,8]. Apparently, associations between various SNPs and adiponectin concentrations are manifested differentially depending on the ethnic background of recruited cohorts of the subjects.…”

Section: Discussionmentioning

confidence: 99%

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Associations of SNPs of the ADIPOQ Gene with Serum Adiponectin Levels, Unstable Angina, and Coronary Artery Disease

et al. 2019

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Adiponectin is encoded by the ADIPOQ gene and participates in the pathogenesis of cardiovascular and metabolic diseases. The goal of the study was to assess associations of rs17300539, rs266729, rs182052, rs2241766, and rs17366743 single nucleotide polymorphisms (SNPs) of the ADIPOQ gene with concentrations of serum adiponectin and with coronary atherosclerosis and type 2 diabetes mellitus in 447 patients (316 men and 131 women) subjected to coronary angiography. SNPs of the ADIPOQ gene of the study participants were genotyped using real-time PCR. Multivariate linear regression adjusted for covariates revealed significant association between rs182052 SNP and serum adiponectin concentration (β= –0.11; 95% confidence interval (95%CI): –0.19, –0.03; p = 0.016). Regression analysis revealed an increase in prevalence of unstable angina (OR (odds ratio) = 2.55; 95%CI 1.4–4.82; p = 0.018) and coronary artery disease (OR = 1.55; 95%CI 1.15–2.09; p = 0.021) per copy of the rs182052 A allele. Prevalence of type 2 diabetes mellitus was higher in subjects with the rs182052 A allele (OR = 2.29; 95%CI 1.29-4.21; p = 0.024). Regression analysis of rs266729 showed that prevalence of unstable angina was increased (OR = 3.59; 95%CI 1.17–10.01; p = 0.045) in the subjects with the GG genotype and prevalence of coronary artery disease (CAD) was significantly increased (OR = 1.48; 95%CI 1.09–2.03; p = 0.045) per copy of the G allele. Haplotype analysis revealed that the subjects with the GCATT haplotype have lower adiponectin levels (β= –0.15; p = 0.042) and higher prevalence of unstable angina (OR = 3.597; p = 0.007) compared with reference haplotype carriers. Thus, the results indicate that minor A allele of rs182052 of the ADIPOQ gene is significantly associated with a decrease in serum adiponectin levels, and two SNPs (rs182052 and rs266729) of the ADIPOQ gene are significantly associated with cardiovascular and metabolic diseases.

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Section: Discussionmentioning

confidence: 99%

“…However, associations described in various studies in different populations are variable apparently due to differences in ethnicity of the participating subjects, study design, cohort size, environmental effects, etc. [7,8,9]. Only a few studies have investigated the SNPs of the ADIPOQ gene in Russia [10,11].…”

Section: Introductionmentioning

confidence: 99%

Associations of SNPs of the ADIPOQ Gene with Serum Adiponectin Levels, Unstable Angina, and Coronary Artery Disease

et al. 2019

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“…Significant associations of ADIPOQ rs2241766 T>G genotype with CVD were observed in Caucasians but not in Asians, hence proposing a potential influence of ethnicity in genetic background. 28 The latest meta-analysis which was carried out by Kanu et al 29 reported that ADIPOQ rs2241766 variant was related with the elevated risk of CAD in various genetic models (allelic, dominant and recessive).…”

Section: Discussionmentioning

confidence: 99%

<p>Role of Adiponectin Gene and Receptor Polymorphisms and Their mRNA Levels with Serum Adiponectin Level in Myocardial Infarction</p>

Saleh

Tayel

Shalaby

et al. 2020

TACG

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Background and Aim Genetic factors are vital participants in the development and progression of myocardial infarction (MI). Adiponectin has been assumed to have a protective role in MI and adiponectin receptors variants could be a determinant for atherosclerosis. We aimed to evaluate the prevalence of ADIPOQ (rs2241766) and ADIPOR2 (rs10773989) polymorphisms and their association with mRNA levels and circulatory adiponectin levels in patients with MI. Subjects and Methods A total of 220 participants were classified into two groups: group 1 included 120 patients with MI, and group 2 involved 100 healthy participants as controls. Genotyping of ADIPOQ (rs2241766) and ADIPOR2 (rs10773989) polymorphisms were analyzed using an allele discrimination assay with real-time PCR and their relative expression or mRNA levels were determined by real-time PCR. Serum adiponectin level was determined using an ELISA technique. Results The ADIPOQ rs2241766 GG genotype and G allele and the CC genotype and C allele of ADIPOR2 rs10773989 were significantly prevalent in patients with MI and associated with increased risk of MI. We detected a marked reduction in serum adiponectin, ADIPOQ and ADIPOR2 mRNA levels in patients than control. The GG genotype of ADIPOQ rs2241766 and the CC genotype of ADIPOR2 rs10773989 had the lowest levels of their mRNA and adiponectin level in both patients and controls. Conclusion Adiponectin gene and receptor variants are potentially related to MI risk; furthermore, their expressions were markedly depressed in MI which suggests their use as potential biomarkers for MI.

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“…Moreover, adiponectin has important role in regulating bone metabolism, inhibiting the osteoprotegerin expression in the osteoblasts and, also, by increasing the differentiation of osteoclasts [41]. Therefore, the ADIPOQ is an important candidate gene, since it has already been associated with metabolic disorders, including arthritis, osteonecrosis and obesity in humans [42–44]. Moreover, this gene acts in several BP possibly involved with the causes of FHS in broilers, as discussed in our study, including lipidemia.…”

Section: Discussionmentioning

confidence: 99%

“…This gene has been considered a potent endogenous inhibitor of adipose triglyceride lipase ( ATGL) revealing a unique mechanism governing lipolysis and fatty acid availability [49]. Zhang and coworkers [44] evidenced that the G0S2 acts as a master regulator of tissue-specific balance of triglycerides storage, mobilization, partitioning of metabolic fuels between adipose and liver, and of the whole-body adaptive energy response.…”

Section: Discussionmentioning

confidence: 99%

Proximal femoral head transcriptome reveals novel candidate genes related to epiphysiolysis in broiler chickens

et al. 2019

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BackgroundThe proximal femoral head separation (FHS) or epiphysiolysis is a prevalent disorder affecting the chicken femur epiphysis, being considered a risk factor to infection which can cause bacterial chondronecrosis with osteomyelitis in broilers. To identify the genetic mechanisms involved in epiphysiolysis, differentially expressed (DE) genes in the femur of normal and FHS-affected broilers were identified using RNA-Seq technology. Femoral growth plate (GP) samples from 35-day-old commercial male broilers were collected from 4 healthy and 4 FHS-affected broilers. Sequencing was performed using an Illumina paired-end protocol. Differentially expressed genes were obtained using the edgeR package based on the False Discovery Rate (FDR < 0.05).ResultsApproximately 16 million reads/sample were generated with 2 × 100 bp paired-end reads. After data quality control, approximately 12 million reads/sample were mapped to the reference chicken genome (Galgal5). A total of 12,645 genes were expressed in the femur GP. Out of those, 314 were DE between groups, being 154 upregulated and 160 downregulated in FHS-affected broilers. In the functional analyses, several biological processes (BP) were overrepresented. Among them, those related to cell adhesion, extracellular matrix (ECM), bone development, blood circulation and lipid metabolism, which are more related to chicken growth, are possibly involved with the onset of FHS. On the other hand, BP associated to apoptosis or cell death and immune response, which were also found in our study, could be related to the consequence of the FHS.ConclusionsGenes with potential role in the epiphysiolysis were identified through the femur head transcriptome analysis, providing a better understanding of the mechanisms that regulate bone development in fast-growing chickens. In this study, we highlighted the importance of cell adhesion and extracellular matrix related genes in triggering FHS. Furthermore, we have shown new insights on the involvement of lipidemia and immune response/inflammation with FHS in broilers. Understanding the changes in the GP transcriptome might support breeding strategies to address poultry robustness and to obtain more resilient broilers.

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Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Cited by 16 publications

References 68 publications

Associations of SNPs of the ADIPOQ Gene with Serum Adiponectin Levels, Unstable Angina, and Coronary Artery Disease

Associations of SNPs of the ADIPOQ Gene with Serum Adiponectin Levels, Unstable Angina, and Coronary Artery Disease

<p>Role of Adiponectin Gene and Receptor Polymorphisms and Their mRNA Levels with Serum Adiponectin Level in Myocardial Infarction</p>

Proximal femoral head transcriptome reveals novel candidate genes related to epiphysiolysis in broiler chickens

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