Associations between the oxytocin receptor gene (OXTR) rs53576 polymorphism and emotional processing of social and nonsocial cues: an event-related potential (ERP) study

Choi, Damee; Minote, Natsumi; Watanuki, Shigeki

doi:10.1186/s40101-016-0125-3

Cited by 16 publications

(11 citation statements)

References 39 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Genotyping of OXTR rs53576 revealed that 77 children had the GG genotype (13.6%), 257 children the GA genotype (45.3%), and 234 children had the AA genotype (41.2%) (Hardy-Weinberg equilibrium: χ 2 = 0.232, p = 0.630). This genotypic frequency in the participants was consistent with those of previous studies which have reported that the frequency of the AA genotype of OXTR rs53576 is relatively high for populations in East Asia 7,22,34 . Given that patients with the GG and GA genotypes share common psychological characteristics 13,19 as mentioned above, we amalgamated subjects with GG and GA genotypes into one group, as has been done in previous studies 13,19,22,34 .…”

Section: Resultssupporting

confidence: 92%

“…The human OXTR gene is located on chromosome 3p25, spans 17 kb and contains four exons and three introns 6 . A single nucleotide polymorphism (SNP) within intron 3 of the OXTR gene, rs53576, is a widely investigated SNP due to its association with individual differences in social behaviours 7–9 . Furthermore, it has been reported that OXTR rs53576 is related to variability of phenotypes in mental health (reviewed in 10 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems

Choi

Tsuchiya

Takei

2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

Previous studies have reported interaction effects of oxytocin receptor genotype (rs53576) and environmental factors on mental health in youth. However, the findings are mixed, especially regarding the type of allele (i.e., A vs. G), and it remains unanswered whether such an interaction presents at an early stage of development. Thus, using a unique longitudinal birth cohort sample in Japan ( n = 568), we examined whether there was an effect of the interaction between the OXTR rs53576 genotype and maternal postpartum depression, as an environmental risk, on behavioural problems in children. Child behavioural problems (internalising and externalising problems) were ascertained using the Strengths and Difficulties Questionnaire when children were 6 years old. Maternal postpartum depression was measured using the Edinburgh Postnatal Depression Scale when children were at 2 months and 10 months of age. The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype ( β = 0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype. This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life. Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems

Choi

Tsuchiya

Takei

2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent ERP study found that male G/G relative to A/A carriers of OXTR rs53576 showed larger N1 amplitudes in response to images of both humans and objects and larger N2 amplitudes in response to images of humans but not objects (Choi et al , 2017). These findings have been proposed to indicate that OXTR rs53576 may affect emotional processing of both social and nonsocial cues.…”

Section: Discussionmentioning

confidence: 99%

Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others’ pain

Luo

Zhang

et al. 2019

Social Cognitive and Affective Neuroscience

View full text Add to dashboard Cite

Empathic neural responses to others’ suffering are subject to both social and biological influences. The present study tested the hypothesis that empathic neural responses to others’ pain are more flexible in an intergroup context in G/G than A/A carriers of the oxytocin receptor gene (OXTR) (rs53576). We recorded event-related brain potentials to painful vs neutral expressions of Asian and Caucasian faces that were assigned to a fellow team or an opponent team in Chinese carriers of G/G or A/A allele of OXTR. We found that G/G carriers showed greater neural responses at 136–176 ms (P2) over the frontal/central region to painful vs neutral expressions of faces with shared either racial or mini group identity. In contrast, A/A carriers showed significant empathic neural responses in the P2 time window only to the faces with both shared racial and mini group identity. Moreover, the racial in-group bias in empathic neural responses varied across individuals’ empathy traits and ethnic identity for G/G but not A/A carriers. Our findings provide electrophysiological evidence for greater flexibility of empathic neural responses in intergroup contexts in G/G ( vs A/A) carriers of OXTR and suggest interactions between OXTR and intergroup relationships on empathy for others’ suffering.

show abstract

“…A recent study also showed that people with the GG genotype exhibit higher emotional stability which was associated with greater perceived social support and in turn general self-reported health (10). Notably, empathy and greater awareness of social cues have been consistently related to having a GG genotype [12–14].…”

Section: Introductionmentioning

confidence: 99%

Associations between spouses’ oxytocin receptor gene polymorphism, attachment security, and marital satisfaction

et al. 2019

View full text Add to dashboard Cite

OXTR rs53576, a polymorphism on the oxytocin receptor gene, has previously been linked to individual differences in social behaviors. That is, individuals with the GG genotype show greater empathy, sociability, and emotional stability. In the context of close relationships, such psychological resources are associated with better relationship outcomes. However, no studies to our knowledge have examined associations between spouses’ OXTR polymorphisms, attachment security, and marital satisfaction. In the current study, 178 married couples (N = 356; ages 37–90) completed self-report measures of attachment security and marital satisfaction and provided saliva samples for genotyping. Results from Actor Partner Interdependence Models showed that individuals who had the GG genotype (actor effect) or had a spouse with the GG genotype (partner effect) reported greater marital satisfaction than individuals with AA or AG genotypes. Furthermore, greater attachment security mediated associations between GG genotype and marital satisfaction.

show abstract

Associations between the oxytocin receptor gene (OXTR) rs53576 polymorphism and emotional processing of social and nonsocial cues: an event-related potential (ERP) study

Cited by 16 publications

References 39 publications

Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems

Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems

Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others’ pain

Associations between spouses’ oxytocin receptor gene polymorphism, attachment security, and marital satisfaction

Contact Info

Product

Resources

About