Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort

Gheerbrant, Hubert; Guillien, Alicia; Vernet, Raphaël; Lupinek, Christian; Pison, Christophe; Pin, Isabelle; Demenais, Florence; Nadif, Rachel; Bousquet, Jean; Pickl, Winfried F.; Valenta, Rudolf; Siroux, Valérie

doi:10.1111/all.14820

Cited by 10 publications

(14 citation statements)

References 42 publications

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“…8,9 Gheerbrant et al reported a significant association between HLA-class II alleles and the allergens Ole e 1, Phl p 2, Phl p 5, and Pla l 1. 10 The non-antigen immunological response depends on the gene polymorphisms involved in innate receptors and signalling pathways. 11 Dendritic cells are directly activated by allergens or by epithelial cells that secrete alarmins, leading to Th2 polarization.…”

Section: Introductionmentioning

confidence: 99%

Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area

Somoza¹,

Pérez‐Sánchez²,

Torres-Rojas³

et al. 2022

JAA

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Background: Allergy can start at early ages, with genetic and environmental factors contributing to its development. Aim:The study aimed to describe the pattern of sensitisation and allergy in children and adolescents of Spanish versus Moroccan ancestry but born in the same rural area of Spain. Methods: Participants were children and adolescents (3-19 years) of Spanish or Moroccan descent, born in Blanca, Murcia (Spain). A detailed questionnaire was completed, and skin prick tests were performed to assess reactions to the most prevalent pollen allergens (O. europaea, P. pratense, S. kali, C. arizonica, P. acerifolia, A. vulgaris and P. judaica) plus molecular components Ole e 1 and Ole e 7. The association with ancestry was verified by studying participants' parents. Results:The study included 693 participants: 48% were aged 3-9 years and 52%, 10-19 years; 80% were of Spanish descent and 20% of Moroccan descent. Sensitisation to Olea europaea, Phleum pratense, Salsola kali and Cupressus arizonica were slightly higher in the Spanish group. The only significant differences were observed in sensitisation to Ole e 1 (p=0.02). Rhinitis, conjunctivitis, and rhinitis plus asthma were significantly higher in the Spanish group (p=0.03, p=0.02, p=0.007, respectively). The sensitisation pattern differed between Spanish and Moroccan parents, and between Moroccan parents and their children, but not between Spanish parents and their children. Conclusion:Both environment and ancestry may influence sensitisation and symptoms. Although the environment seems to have a stronger influence, other factors may contribute to the differences in prevalence and in the clinical entities in people of Spanish versus Moroccan descent.

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Section: Introductionmentioning

confidence: 99%

Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area

Somoza¹,

Pérez‐Sánchez²,

Torres-Rojas³

et al. 2022

JAA

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“…Cross reactivity between different allergens "production of IgE in response to one allergen, and then bind to similar proteins in another allergens" have been noticed by assessing the correlation coefficient "r value" (18) . R value was high within this study between allergens of plant origin "peanuts, potatoes, carrots, apples, soya bean, wheat flour and pollens" with significant p value.…”

Section: Discussionmentioning

confidence: 99%

The Most Common Allergens in Pediatric Patients in Iraq

Al-hadi¹,

Alshiblawy²,

Al-Jazaeri³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: The allergic diseases are considered as an abnormal immune system response to harmless environmental stimuli usually proteins. Objective: This study aimed to examine the allergen profile in Iraqi children age range 1 to 10 years old. Methods: A cross-sectional observational study was conducted during the period from January 2017 to February 2019. Allergic children age ranged from 1 to 10 years old. They were collected from many clinics in Al-Najaf City, Iraq. The pediatric penal kit Polycheck® -Diagnostics was used to reveal to the sensitivity of 20 different allergens. Results:The number and percentage of allergic children to each allergen were recorded. The inhalant allergens had higher percentage as follow: Mugwort pollen 52%, D. farinae 45%, both Birch and Timothy grass pollens 40%. While the higher percentages of ingested allergens were in Peanut and Apple allergens 31.67%, Carrot 26.67%, Potato's allergens 21.67%, Soya bean 20% and Wheat flour allergens 18.33%. While the egg white showed no allergic sensitivity in all samples of children but the allergic to egg yolk allergens were 8.33%. Conclusion:Approximately 93% of the children were allergic to at least one inhalant. Studying the rates of allergens in Iraqi environment and its related allergens is an important point in the planning for prevention and control of allergy.

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“… 48 We observed 2 cis and 638 trans ‐eQTLs which have shown association with the expression of the DEGs in our data. Novel genes that were targets of these regulatory variants include the following: IL‐1B, HLA‐DQB1 , 49 , 50 , 51 MAPK3 , MUC‐21 and TUG1 . Many of these genes are known candidates for allergic or tonsillar diseases revealed through genome‐wide association studies (GWAS).…”

Section: Discussionmentioning

confidence: 99%

Tonsillar transcriptional profiles in atopic and non‐atopic subjects

Hanif

Ivaska

Ahmad

et al. 2022

Allergy

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Background Emerging research suggests that local lymphatic tissue such as tonsils have important role in regulating the immune responses. However, allergen sensitization‐induced alterations in transcriptome of tonsils are not known. Objectives To examine the key differences in tonsillar gene expression between atopic and non‐atopic subjects and further by type of sensitization. Methods RNA‐sequencing was performed on 52 tonsillar samples from atopic and non‐atopic tonsillectomy patients. Sensitization to common food‐ and aero‐allergen was defined by allergen specific IgE. Following groups were studied: (1) aero‐ and food‐allergen sensitized (AS+FS) versus non‐sensitized (NS), (2) aeroallergen‐sensitized (AS) versus food‐allergen sensitized (FS), (3) AS versus NS, (4) FS versus NS. Bioinformatics analysis was done using DESeq2(v3.10.2), WGCNA and GATK pipeline in R software (v3.3.1). Protein–protein interaction network was made from String database. Results We studied 13 aeroallergen‐sensitized, 6 food‐allergen sensitized, 4 both food‐and aero‐allergen‐sensitized and 29 non‐sensitized tonsillectomy patients. Overall, 697 unique differentially expressed genes (DEGs) were detected in all sensitized subgroups including chemokines (CXCL2, CXCL8, CXCL10, CXCL11), IL‐20RA, MUC1 and MUC20. When comparing different groups, the gene expression profiles overlapped except the AS versus FS group comparison, suggesting significantly different gene expression between the two sensitization subgroups. Furthermore, aeroallergen‐sensitized subjects had more prominent immune responses compared with non‐sensitized and food‐allergen sensitized subjects including gene expression for IL‐17 pathway and Toll‐like receptor signalling pathway. Conclusion Allergic sensitization is associated with extensive tonsillar transcriptomic alterations and changes in immune related genes and pathways. Distinct differences were found between aero‐allergen and food‐allergen sensitization.

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Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort

Cited by 10 publications

References 42 publications

Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area

Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area

The Most Common Allergens in Pediatric Patients in Iraq

Tonsillar transcriptional profiles in atopic and non‐atopic subjects

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