Associations between Soluble APO-1 (Fas/CD95) Concentrations and Hematopoietic Activity in Healthy Women

Choi, Jong Weon

doi:10.1159/000093645

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…У дітей у тесті імунофлуоресценції визначали фенотип лімфоцитів периферійної крові за ідентифікацією диференційованих антигенів із застосуванням моноклональних антитіл, які належать до кластера диференціації CD 95 + (Fas/CD 95 )апоптозу лімфоцитів (Debatin et al, 2009;Choi, 2016).…”

Section: матеріал і методи дослідженьunclassified

“…Цей механізм самостійно або разом із перфорингранзимовим компонентомголовні шляхи цитотоксичного кілінгу, що здійснюється Т-і NK-клітинами. Елімінація цих клітин, що вже виконали свою функцію, також відбувається за допомогою FAS-опосередкованого апоптозу (Choi, 2016). Клональна делеція незрілих Т-клітин у вилочковій залозі відбувається без участі Fas/FasL системи.…”

Section: обговоренняunclassified

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Bile lipids in rats under chronic social stress

Gan

Pоpеl²

2017

Regul. Mech. Biosyst.

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Our experiments studied changes in lipid compound of bile of non-purebred male rats under the condition of social stress while the preparation “Korvitin” was used against the stress. Using the method of thin-layer chromatography, we determined the concentrations of phospholipids, cholesterol and its esters, free fatty acids and triglycerides in the animals’ bile, which was obtained through vivesection a day and a month after the rats were first subjected to chronic social stress (model of social defeat), and also in the bile of the animals which were treated intragastrically with “Korvitin” against the stress (1 mg/kg, 7 days). In the bile of the male rats which experienced chronic social stress the concentration of free cholesterol decreased and the content of its esters increased both immediately after the initiation of stress and after a month of exposure to stress. The concentration of free fatty acids in the bile decreased after modeling chronic social stress, but increased in liver secretion, taken a month after the animals first experienced stress. In the bile of male rats immediately after the procedure of exposing the animals to stress, the content of phospholipids decreased. Using “Korvitin” during the modeling of social stress caused decrease in the content of phospholipids in the rats’ bile and caused significant increase in the concentration of free fatty acids, triglycerides and cholesterol esters in the liver secretion. The study found significant changes in the concentration of lipids in the bile and in their distribution in the organism of male rats under the conditions of experimentally induced chronic stress. The effect of stress on the bile of rats requires further study for determining its pathogenic role.

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Section: матеріал і методи дослідженьunclassified

Section: обговоренняunclassified

Bile lipids in rats under chronic social stress

Gan

Pоpеl²

2017

Regul. Mech. Biosyst.

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“…A study conducted in a healthy adult population showed that Apo1fas was positively correlated with triglycerides and negatively correlated with High-Density Lipoprotein (HDL). Hence, it is believed that adiposity is related to apoptosis or tissue damage; however, the exact mechanism remains unknown [28]. In children, the role of apoptosis has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight

Katsa,

Kostopoulou,

Nomikos

et al. 2023

IJMS

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Oxidative stress and apoptosis are involved in the pathogenesis of obesity-related diseases. This observational study investigates the antioxidant and apoptotic markers response to an oral glucose tolerance test (OGTT) in a population of overweight children and adolescents, with normal (NGT) or impaired glucose tolerance (IGT). Glucose, insulin, and C-peptide concentrations, as well as oxidative stress (SOD, GPx3) and apoptotic markers (Apo1fas, cck18), were determined at T = 0, 30, 60, 90, 120, and 180 min after glucose intake during OGTT. The lipid profile, thyroid function, insulin-like growth factor1, leptin, ghrelin, and adiponectin were also measured at baseline. The 45 participants, with a mean age of 12.15 (±2.3) years old, were divided into two subcategories: those with NGΤ (n = 31) and those with IGT (n = 14). The area under the curve (AUC) of glucose, insulin, and C-peptide was greater in children with IGT; however, only glucose differences were statistically significant. SOD and GPx3 levels were higher at all time points in the IGT children. Apo1fas and cck18 levels were higher in the NGT children at most time points, whereas Adiponectin was lower in the IGT group. Glucose increased during an OGTT accompanied by a simultaneous increase in antioxidant factors, which may reflect a compensatory mechanism against the impending increase in oxidative stress in children with IGT.

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Associations between Soluble APO-1 (Fas/CD95) Concentrations and Hematopoietic Activity in Healthy Women

Cited by 2 publications

References 10 publications

Bile lipids in rats under chronic social stress

Bile lipids in rats under chronic social stress

The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess Body Weight

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