Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts

Eick, Stephanie M.; Geiger, Sarah Dee; Aung, Max T.; Barrett, Emily S.; Bush, Nicole R.; Cordero, José F.; Ferguson, Kelly K.; Meeker, John D.; Milne, Ginger L.; Nguyen, Ruby H.N.; Padula, Amy; Sathyanarayana, Sheela; Welch, Barrett M.; Schantz, Susan L.; Woodruff, Tracey J.; Morello‐Frosch, Rachel

doi:10.1016/j.scitotenv.2022.155596

Cited by 14 publications

(6 citation statements)

References 53 publications

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“…These covariates were chosen via a directed acyclic graph (DAG; Figure S3), a tool commonly applied in epidemiology research that is used to identify the minimal set of covariates to be retained in adjusted models. Our DAG was supplemented by associations between exposures and outcomes in our study population (Eick et al., 2021; Eick, Geiger, Alshawabkeh, Aung, Barrett, Bush, Cordero, et al., 2022). Smoking status was not included as a confounder as only one participant reported smoking during pregnancy.…”

Section: Methodsmentioning

confidence: 99%

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Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months

Eick,

Ortlund,

Aguiar

et al. 2024

Developmental Psychobiology

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Oxidative stress has been identified as an important biological pathway leading to neurodevelopmental delay. However, studies assessing the effects of oxidative stress on cognitive outcomes during infancy, a critical period of neurodevelopment, are limited. Our analysis included a subset of those enrolled in the Illinois Kids Development Study (N = 144). Four oxidative stress biomarkers (8‐isoprostane‐PGF2α, 2,3‐dinor‐5,6‐dihydro‐8‐iso‐PGF2α, 2,3‐dinor‐8‐iso‐PGF2α, and prostaglandin‐F2α) were measured in second and third trimesters urine and were averaged. Infant cognition was measured using a visual recognition memory task consisting of five blocks, each with one familiarization trial (two identical stimuli) and two test trials (one familiar and one novel stimulus). Outcomes measured included average run duration (a measure of information processing speed), novelty preference (a measure of recognition memory), time to reach familiarization, and shift rate (measures of attention). Linear regression was used to estimate associations between individual oxidative stress biomarkers and each outcome. Increasing 8‐isoprostane‐PGF2α, 2,3‐dinor‐8‐iso‐PGF2α, and prostaglandin‐F2α were associated with a decrease in novelty preference (β = −0.02, 95% confidence interval [CI] = −0.03, 0.00; β = −0.02, 95% CI = −0.04, 0.00; β = −0.01, 95% CI = −0.02, 0.00, respectively), as well as a modest increase in shift rate. These findings suggest that oxidative stress may be associated with poorer recognition memory in early infancy.

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Section: Methodsmentioning

confidence: 99%

“…Using analytic techniques previously described in detail (Eick et al, 2022 ;Taibl et al, 2022), we quantified urinary levels of four oxidative stress biomarkers using liquid chromatography-mass spectrometry.…”

Section: Measurement Of Urinary Oxidative Stress Biomarkersmentioning

confidence: 99%

Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months

Eick,

Ortlund,

Aguiar

et al. 2024

Developmental Psychobiology

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“…The samples utilize demographic diversity across the U.S. and serve as a foundation to expand measurements in future studies across additional ECHO samples. This approach has been applied in previous studies within the ECHO program with robust sensitivity analyses to account for different cohort characteristics. , …”

Section: Methodsmentioning

confidence: 99%

“…This approach has been applied in previous studies within the ECHO program with robust sensitivity analyses to account for different cohort characteristics. 24 , 25 …”

Section: Methodsmentioning

confidence: 99%

“…This approach has been applied in previous studies within the ECHO program with robust sensitivity analyses to account for different cohort characteristics. 24,25 The CiOB cohort participants are based in San Francisco, CA, and were recruited during the second trimester of pregnancy from three University of California San Francisco hospitals. Women included in the CiOB cohort had to be ≥18 years of age, primarily speak English or Spanish, and have a singleton pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Suthar,

Manea,

Pak

et al. 2024

Environ. Sci. Technol.

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Prenatal per-and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipids�metabolic and inflammation pathway indicators. We estimated associations between prenatal PFAS exposure and bioactive lipids, measuring 12 serum PFAS and 50 plasma bioactive lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained through linear mixed models and meta-analysis, adjusting the former for false discovery rates. Associations between the PFAS mixture and bioactive lipids were estimated using quantile g-computation. Pairwise analyses revealed bioactive lipid levels associated with PFDeA, PFNA, PFOA, and PFUdA (p < 0.05) across three enzymatic pathways (cyclooxygenase, cytochrome p450, lipoxygenase) in at least one combined cohort analysis, and PFOA and PFUdA (q < 0.2) in one linear mixed model. The strongest signature revealed doubling in PFOA corresponding with PGD2 (cyclooxygenase pathway; +24.3%, 95% CI: 7.3−43.9%) in the combined cohort. Mixture analysis revealed nine positive associations across all pathways with the PFAS mixture, the strongest signature indicating a quartile increase in the PFAS mixture associated with PGD2 (+34%, 95% CI: 8−66%), primarily driven by PFOS. Bioactive lipids emerged as prenatal PFAS exposure biomarkers, deepening insights into PFAS' influence on pregnancy outcomes.

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Low level of urinary cotinine in pregnant women also matters: variability, exposure characteristics, and association with oxidative stress markers

Zhang

Wan

Liu

et al. 2023

Environ Sci Pollut Res

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Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts

Cited by 14 publications

References 53 publications

Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months

Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Low level of urinary cotinine in pregnant women also matters: variability, exposure characteristics, and association with oxidative stress markers

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