Associations between single nucleotide polymorphisms of GDF9 and BMP15 genes and litter size in two dairy sheep breeds of Greece

Liandris, Emmanouil; Kominakis, A.; Ανδρεάδου, Μαργαρίτα; Kapeoldassi, K.; Chadio, Stella; Tsiligianni, Theodora; Gazouli, Maria; Ikonomopoulos, Ioannis

doi:10.1016/j.smallrumres.2012.04.004

Cited by 17 publications

(16 citation statements)

References 14 publications

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“…Moreover, in some cases, a complete absence of homozygous individuals for the detected mutations was found. Possible reasons to explain the absence of such homozygous mutations in a single breed or in both the considered breeds may be (1) the sample numbers detected were relatively less, despite the verified Hardy-Weinberg equilibrium of the populations; (2) some homozygous mutations in GDF9 gene may be associate with reduced fitness of individuals or infertility as supposed by other authors, although this effect seems to be breed-specific (Hanrahan et al, 2004;Barzegari et al, 2010;Roy et al, 2011;Liandris et al, 2012); (3) these genotypes may not exist in the considered populations or the frequencies of these alleles may be low.…”

Section: Resultsmentioning

confidence: 93%

Analysis of major fecundity genes in autochthonous Laticauda and Bagnolese sheep breeds

Albarella

Ciotola

Selvaggi

et al. 2015

Small Ruminant Research

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Section: Resultsmentioning

confidence: 93%

Analysis of major fecundity genes in autochthonous Laticauda and Bagnolese sheep breeds

Albarella

Ciotola

Selvaggi

et al. 2015

Small Ruminant Research

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“…These genes are produced by the ovary and show intense effects (Knight and Glister, 2006). Moreover, these two oocyte-specific factors induce mitosis along with differentiation in the follicular somatic cells during follicular development through a paracrine signaling pathway (Paulini and Melo, 2011). They are also found to play pivotal roles H. Ghoreishi et al: Identification of mutations in BMP15 and GDF9 genes in specifying ovulation rate and litter size (Galloway et al, 2000;Hanrahan et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Identification of mutations in <i>BMP15</i> and <i>GDF9</i> genes associated with prolificacy of Markhoz goats

2019

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The Markhoz is a local goat breed in the Kurdistan region of Iran. The mohair obtained from these animals plays an important cultural role and is used for making local clothes in the Kurdistan region. This breed is a low-fecundity local goat, and searching for genes associated with fertility of these goats is important for their breeding. Moreover, this research is complementary to prior studies of candidate genes associated with fertility. The growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are attractive candidates expressed by the oocyte and are associated with increased ovulation rate in sheep. However, there are no reports on single nucleotide polymorphisms associated with fertility of Markhoz goats. Hence, we studied these candidate genes and found two novel mutations (g.233C>A and g.755T>G) in GDF9 exon I and in BMP15 exon II, respectively. Furthermore, we investigated their association with prolificacy. These nucleotide changes are detectable with the PCR-RFLP method and can be used in the screening for highly fecund goats. Both of the mutations significantly increased litter size in heterozygote form for BMP15 and homozygote form for GDF9 in this goat breed. Homozygote females for the BMP15 mutation were not identified in the Markhoz breed, which is similar to the situation found in Belclare sheep, small-tailed Han sheep, and Jining Grey goats.

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“…Litter size GDF9, BMP15, BMPR1B/FecB and B4GALNT2 PCR-RFLP [89,99] Causal variants linked to litter size (prolificacy) were growth differential factor (GDF9), bone morphogenetic protein 15 (BMP15), bone morphogenetic protein receptor 1B (BMPR1B) (FecB allele) genes and beta-1,4-N-acetyl-galactosaminyl transferase 2 (B4GALNT2) [99]. GDF 9 is an autosomal gene and is located on chromosome 5 and BMP15 is located on the X-chromosome.…”

Section: Causal Variants Methods Used Referencesmentioning

confidence: 99%

“…This was done in the study of Liandris et al [89] using PCR-RFLP to verify the presence of the GDF9 and FecB within two Greek sheep breeds. Following screening for causal variants, introgression of individuals carrying favorable loci into sheep flocks lacking these loci can occur.…”

Section: Causal Variants Methods Used Referencesmentioning

confidence: 99%

“…This can be done using different methods, for example, studying the genetic diversity and population structure of sheep. This serves as a backbone for genome wide association studies (GWAS) that can be used to associate phenotypes with causal variants [23,89]. Causal variants have been identified for various traits important for sustainability including reproduction [23], gastrointestinal parasite resistance [90,91], growth and meat production [92][93][94], wool traits [95] and adaptation in extreme environments [96] (Table 2).…”

Section: Applying Genomics To Improve Traits Important For Sustainablmentioning

confidence: 99%

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Genetic Traits of Relevance to Sustainability of Smallholder Sheep Farming Systems in South Africa

et al. 2017

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Sustainable livestock production is important to ensure continuous availability of resources for future generations. Most smallholder livestock farming systems in developing countries have been perceived to be environmentally, socially and economically unsustainable. Farming with livestock that is robust and adaptable to harsh environments is important in developing countries especially in semi-arid and arid environments. This review discusses the different sheep farming systems employed by smallholder farmers and associated sustainability problems facing them. The review also gives an overview of sustainability indicators and limitations to the sustainability for the different smallholder sheep production systems in South Africa. It is argued that genetic diversity is important for sustainability and needs to be maintained in sheep for sustainable production and reproduction performance. The application of traditional breeding and genomics to ensure sustainable production is explored. Animal breeding approaches, specifically genomics can be applied to improve areas of environmental sustainability of smallholder sheep farming systems but must be targeted to the specific production environments, challenges, and opportunities of smallholder production. The genetic traits important for sustainability, the role of genomics in improving these traits and linking these genetic traits to different farming systems in South Africa are discussed.

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Associations between single nucleotide polymorphisms of GDF9 and BMP15 genes and litter size in two dairy sheep breeds of Greece

Cited by 17 publications

References 14 publications

Analysis of major fecundity genes in autochthonous Laticauda and Bagnolese sheep breeds

Analysis of major fecundity genes in autochthonous Laticauda and Bagnolese sheep breeds

Identification of mutations in <i>BMP15</i> and <i>GDF9</i> genes associated with prolificacy of Markhoz goats

Genetic Traits of Relevance to Sustainability of Smallholder Sheep Farming Systems in South Africa

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Associations between single nucleotide polymorphisms of GDF9 and BMP15 genes and litter size in two dairy sheep breeds of Greece

Cited by 17 publications

References 14 publications

Analysis of major fecundity genes in autochthonous Laticauda and Bagnolese sheep breeds

Analysis of major fecundity genes in autochthonous Laticauda and Bagnolese sheep breeds

Identification of mutations in &lt;i&gt;BMP15&lt;/i&gt; and &lt;i&gt;GDF9&lt;/i&gt; genes associated with prolificacy of Markhoz goats

Genetic Traits of Relevance to Sustainability of Smallholder Sheep Farming Systems in South Africa

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Identification of mutations in <i>BMP15</i> and <i>GDF9</i> genes associated with prolificacy of Markhoz goats