Associations between resumption of postpartum ovarian activity, uterine health and concentrations of metabolites and acute phase proteins during the transition period in Holstein cows

Relationship between serum metabolites, body condition, peri- and postpartum health and resumption of postpartum cyclicity in dairy cows

“…The NCY group had lower serum albumin concentrations than did the CY group, which was consistent with previous studies (Obese et al, 2015). Krause et al (2014) shows that cows with early RPC have greater 13 serum albumin throughout the pre-and post-partum periods than cows with delayed RPC.…”

“…Our results were supported by a previous study in which the proportion of polymorphonuclear cells and metricheck scores during the 5 week postpartum period were lower in cows that were ovulating within 4 weeks postpartum versus those who did not ovulate until 7 weeks postpartum (Senosy et al, 2009). Similarly, cows with subclinical endometritis are less likely to have estrous cyclicity than those without (Ribeiro et al, 2013), and cows with higher uterine polymorphonuclear cell counts are more likely to have delayed RPC (Krause et al, 2014). Exacerbated release of proinflammatory cytokines by endometrial cells may affect follicular development, which may reduce steroidogenesis in granulosa cells (Spicer and Alpizar, 1994) and inhibit growth of the first postpartum dominant follicle (Sheldon et al, 2002).…”

“…However, several other studies show no relationship between serum NEFA concentrations and RPC (Garverick et al, 2013;Kafi and Mirzael, 2010;Krause et al, 2014;Patton et al, 2007;Reist et al, 2000;Shrestha et al, 2005). The reason for this inter-study discrepancy and inconsistency is unclear.…”

“…Likewise, some blood metabolites (such as BHBA and/or NEFA) during the transition are associated with delayed RPC and reduced fertility (Wathes et al, 2007). Previous studies also show that lower albumin and higher NEFA, BHBA, and aspartate aminotransferase (AST) are associated with delayed RPC (Kafi and Mirzael, 2010;Krause et al, 2014;Samarütel et al, 2008).…”

“…In addition to NEB, several peri-and postpartum problems such as abnormal calving, clinical ketosis, and metritis have been associated with delayed RPC, although the relationship between retention of the placenta and RPC is controversial (Krause et al, 2014;Opsomer et al, 2000;Vercouteren et al, 2015;Zain et al, 1995). Blood metabolites, change in BCS, peri-and postpartum disorders, and RPC may be interrelated, and knowledge of these relationships may help establish strategies for dairy reproductive management.…”