Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

Colina, Adrián Noriega de la; Badji, Atef; Robitaille-Grou, Marie-Christine; Gagnon, Christine; Boshkovski, Tommy; Lamarre-Cliché, Maxime; Joubert, Sven; Gauthier, Claudine; Bherer, Louis; Cohen‐Adad, Julien; Girouard, Hélène

doi:10.1161/hypertensionaha.120.16124

Cited by 4 publications

(4 citation statements)

References 63 publications

(81 reference statements)

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“…228 In humans, a higher relative morning surge (increase in SBP) was associated with lower regional CBF to gray matter in older adults treated for hypertension. 229…”

Section: Cerebral Blood Flowmentioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

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Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

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“…228 In humans, a higher relative morning surge (increase in SBP) was associated with lower regional CBF to gray matter in older adults treated for hypertension. 229…”

Section: Cerebral Blood Flowmentioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

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“…These trigger the morning surge in blood pressure, the magnitude of which is reflective of sympathetic activity, is associated with an increased risk of cardiovascular events, 90 and is associated with a lower CBF in older adults. 91 Subsequently, blood pressure falls in the mid-morning, particularly in patients on antihypertensive medication, often with a bimodal pattern during the day driven by a postprandial early afternoon fall in blood pressure. 92 This diurnal variation in blood pressure determines the input pressure to the brain, providing greater flow in active periods, but with an increased risk of hypoperfusion during the night.…”

Section: Mechanisms Of Circadian and Diurnal Control Of Physiologymentioning

confidence: 99%

Circadian and Diurnal Regulation of Cerebral Blood Flow

Webb,

Klerman,

Mandeville

2024

Circulation Research

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Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal variation in the risk of stroke, either through factors that trigger stroke or due to impaired compensatory mechanisms. Cerebral blood flow results from the integration of systemic hemodynamics, including heart rate, cardiac output, and blood pressure, with cerebrovascular regulatory mechanisms, including cerebrovascular reactivity, autoregulation, and neurovascular coupling. We review the evidence for the circadian and diurnal variation in each of these mechanisms and their integration, from the detailed evidence for mechanisms underlying the nocturnal nadir and morning surge in blood pressure to identifying limited available evidence for circadian and diurnal variation in cerebrovascular compensatory mechanisms. We, thus, identify key systemic hemodynamic factors related to the diurnal variation in the risk of stroke but particularly identify the need for further research focused on cerebrovascular regulatory mechanisms.

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“…Blood pressure readings were done every 30 min during a 24 h period. The installation and calibration process has been previously reported [26].…”

Section: Cardiovascular Measurementsmentioning

confidence: 99%

Arterial stiffness and age moderate the association between physical activity and global cognition in older adults

Colina

Badji

Lamarre-Cliché

et al. 2021

Journal of Hypertension

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Arterial stiffness and age moderate the association between physical activity and global cognition in older adultsAdria ´n Noriega de la Colina a,b,g,i,j , Atef Badji b,c,d,i,j , Maxime Lamarre-Cliche e , Louis Bherer b,f,g , He ´le `ne Girouard b,h,i,j,Ã , and Navin Kaushal k,Ã Background: Evidence supports that time spent on physical activity has beneficial effects on cognition in older adults. Nevertheless, whether these beneficial effects are still present at the intersection of different levels of arterial stiffness and age is uncertain.Methods: One hundred and ten healthy older adults aged 60-75 years were examined for arterial stiffness [carotidfemoral pulse wave velocity (cf-PWV)], global cognition (composite score of Montreal Cognitive Assessment, and Mini-Mental State Examination), and self-reported physical activity (PACED diary). Using PROCESS macro for SPSS, we evaluated if cf-PWV (moderator 1), and age (moderator 2) moderate the relationship between physical activity (X) and global cognition (Y). The threshold for high stiffness was set at 8.5 m/s based on previous studies that reported this cut-off as more appropriate for classifying cerebrovascular risk groups.Results: Physical activity had a positive effect on cognition in young-elderly adults (<68.5 years) with a cf-PWV of at least 8.5 m/s (b ¼ 0.48, SE ¼ 0.193, P ¼ 0.014, 95% CI ¼ 0.100-0.868

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Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

Cited by 4 publications

References 63 publications

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Circadian and Diurnal Regulation of Cerebral Blood Flow

Arterial stiffness and age moderate the association between physical activity and global cognition in older adults

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