294Abstract Physical inactivity contributes to all-cause mortality and higher hospitalization risk. The present study aimed to estimate relation between sedentary lifestyle and cardiovascular parameters. A cross-sectional study was conducted on the retired defense personnel to relate socio-demographic variables, body mass index, dietary habits, alcohol, sleep, stress, dysglycaemia, hypertension and dyslipidemia with sedentary behaviour. Total prevalence of sedentary behaviour was 62.40%, which increases with age. Insomnia, stress, low education, unemployment, and upper social class were associated with sedentary behavior. A statistical inverse association of alcohol and sedentary behaviour was reported. Higher prevalence of metabolic syndrome, hypertension and obesity was observed in sedentary than active subjects. Rising sedentary lifestyles and its association with metabolic syndrome prompt to develop strategies of proper city designs with sidewalks, personal motivation, climbing stairs, doing household work, use of standing desks and break-prompting software at work place to discourage this behaviour.