Associations between prenatal multiple plasma metal exposure and newborn telomere length: Effect modification by maternal age and infant sex

Tang, Peng; He, Wanting; Shao, Yantao; Liu, Bihu; Huang, Huishen; Liang, Jun; Liao, Qian; Tang, Ying; Mo, Meile; Zhou, Yong; Li, Han; Huang, Dongping; Liu, Shun; Zeng, Xianmin; Qiu, Xiaoqiang

doi:10.1016/j.envpol.2022.120451

Cited by 13 publications

(4 citation statements)

References 102 publications

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“…Since both our dependent variables (TG, TC, HDL-C, LDL-C) and independent variable (MCs) were log-transformed, the results were re-transformed by exponentiating the coefficients and were presented as percent changes [72]. With MCs serv-ing as a continuous exposure variable, using the formula [exp (ln2 × β) − 1] × 100% [73], the regression coefficients were converted and expressed as the percent change in blood lipids with each doubling of the serum MCs levels. On the other hand, the exposure variables were also divided into quartiles and introduced into the models as categorical variables for further analysis, and the percent changes were estimated by comparing each of the upper three quartiles to the lowest quartile using the formula [exp (β) − 1] × 100.…”

Section: Discussionmentioning

confidence: 99%

Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China

Feng

Cao

Tang

et al. 2023

Toxins

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Increasing evidence from experimental research suggests that exposure to microcystins (MCs) may induce lipid metabolism disorder. However, population-based epidemiological studies of the association between MCs exposure and the risk of dyslipidemia are lacking. Therefore, we conducted a population-based cross-sectional study involving 720 participants in Hunan Province, China, and evaluated the effects of MCs on blood lipids. After adjusting the lipid related metals, we used binary logistic regression and multiple linear regression models to examine the associations among serum MCs concentration, the risk of dyslipidemia and blood lipids (triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)). Moreover, the additive model was used to explore the interaction effects on dyslipidemia between MCs and metals. Compared to the lowest quartile of MCs exposure, the risk of dyslipidemia [odds ratios (OR) = 2.27, 95% confidence interval (CI): 1.46, 3.53] and hyperTG (OR = 3.01, 95% CI: 1.79, 5.05) in the highest quartile was significantly increased, and showed dose–response relationships. MCs were positively associated with TG level (percent change, 9.43%; 95% CI: 3.53%, 15.67%) and negatively associated with HDL-C level (percent change, −3.53%; 95% CI: −5.70%, −2.10%). In addition, an additive antagonistic effect of MCs and Zn on dyslipidemia was also reported [relative excess risk due to interaction (RERI) = −1.81 (95% CI: −3.56, −0.05)], and the attributable proportion of the reduced risk of dyslipidemia due to the antagonism of these two exposures was 83% (95% CI: −1.66, −0.005). Our study first indicated that MCs exposure is an independent risk factor for dyslipidemia in a dose–response manner.

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Section: Discussionmentioning

confidence: 99%

Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China

Feng

Cao

Tang

et al. 2023

Toxins

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“…The results of the linear regression were converted and presented as the percent change. For each doubling of urinary glyphosate concentrations, the formula of (e (ln2× β) -1) × 100% was applied to calculate the percentage change in HbA1c [ 28 ]. Moreover, GLMs were constructed by dividing the urinary glyphosate levels into quartiles and choosing the lowest quartile as the baseline.…”

Section: Methodsmentioning

confidence: 99%

Relationship of urinary glyphosate concentrations with glycosylated hemoglobin and diabetes in US adults: a cross-sectional study

Tang,

Wang,

Liao

et al. 2024

BMC Public Health

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Background Glyphosate is a commonly used herbicide worldwide and is purportedly associated with multiple health effects. Research assessing the association of glyphosate concentrations with glycosylated hemoglobin (HbA1c) levels and the prevalence of diabetes is scarce. We sought to evaluate the association between urinary glyphosate levels and HbA1c levels and the prevalence of diabetes. Methods A total of 2,745 adults in the National Health and Nutrition Examination Survey from 2013 to 2016 were included in this study. Generalized linear models (GLM) were applied to evaluate the associations of glyphosate concentrations with HbA1c levels and the prevalence of diabetes. The dose–response relationship was examined using restricted cubic splines (RCS). Results Significantly positive correlations of urinary glyphosate concentrations with HbA1c levels (percentage change: 1.45; 95% CI: 0.95, 1.96; P < 0.001) and the prevalence of diabetes (OR: 1.45; 95% CI: 1.24, 1.68; P < 0.001) were found after adjustment. Compared with the lowest quartile of glyphosate levels, the highest quartile was positively associated with HbA1c levels (percentage change: 4.19; 95% CI: 2.54, 5.85; P < 0.001) and the prevalence of diabetes (OR: 1.89; 95% CI: 1.37, 2.63; P < 0.001). The RCS curves demonstrated a monotonically increasing dose–response relationship between urinary glyphosate levels and the prevalence of diabetes and HbA1c levels. Conclusions Urinary glyphosate concentrations are positively associated with HBA1c levels and the prevalence of diabetes. To verify our findings, additional large-scale prospective investigations are required.

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“…The mean RTL was calculated using the 2 -ΔΔCt method recommended by Tang (19) as follows. Relative T/S = 2 –(ΔCt Samples to be tested − ΔCt positive control) , where ΔCt (sample to be tested) is the difference between the CT value of the TEL gene after telomere amplification in the sample to be tested, and the corresponding 36B4 gene CT value and ΔCt (positive control) is the difference between the CT value of the TEL gene after telomere amplification in the DNA telomere of the reference sample of the positive standard and the corresponding 36B4 gene CT value.…”

Section: Methodsmentioning

confidence: 99%

“…These primers were purchased from Invitrogen, USA. The DNA of any qualified sample was selected as the standard and diluted to 200, 100, 50, 25, 12 The mean RTL was calculated using the 2 -ΔΔCt method recommended by Tang (19) as follows. Relative T/S = 2 -(ΔCt Samples to be tested − ΔCt positive control)…”

Section: Collection Of Blood Samples and Measurement Of Relative Telo...mentioning

confidence: 99%

Association between the dietary antioxidant index and relative telomere length of leucocytes in the Chinese population

Zhao,

Jin,

Zhang

et al. 2023

Br J Nutr

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Dietary antioxidant indices (DAI) may be potentially associated with relative telomere length in leukocytes (RTL). This study aimed to investigate the relationship between DAI and RTL. A cross-sectional study involving 1656 participants was conducted. A generalized linear regression model (GLM) and a restricted cubic spline (RCS) model were used to assess the correlation of DAI and its components with RTL. Generalized linear regression analysis revealed that DAI (β = 0.005, P = 0.002) and the intake of its constituents vitamin C (β = 0.043, P = 0.027), vitamin E (β = 0.088, P < 0.001), selenium (β = 0.075, P = 0.003), and zinc (β = 0.075, P = 0.023) were significantly and positively correlated with RTL. Gender-stratified analysis showed that DAI (β = 0.006, P = 0.005) and its constituents vitamin E (β = 0.083, P = 0.012), selenium (β = 0.093, P = 0.006), and zinc (β = 0.092, P = 0.034) were significantly and positively correlated with RTL among females. Meanwhile, among males, only vitamin E intake (β = 0.089, P = 0.013) was significantly and positively associated with RTL. RCS analysis revealed linear positive associations between DAI and its constituents’ (vitamin E, selenium, and zinc) intake and RTL in the total population. Sex-stratified analysis revealed a linear positive correlation between DAI and its constituents’ (vitamin E, selenium, and zinc) intake and RTL in females. Our study found a significant positive correlation between DAI and RTL, with gender differences.

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Associations between prenatal multiple plasma metal exposure and newborn telomere length: Effect modification by maternal age and infant sex

Cited by 13 publications

References 102 publications

Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China

Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China

Relationship of urinary glyphosate concentrations with glycosylated hemoglobin and diabetes in US adults: a cross-sectional study

Association between the dietary antioxidant index and relative telomere length of leucocytes in the Chinese population

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