Associations between physical function, dual-task performance and cognition in patients with mild Alzheimer's disease

Sobol, Nanna Aue; Hoffmann, Kristine; Vogel, Asmus; Lolk, Annette; Gottrup, Hanne; Høgh, Peter; Hasselbalch, Steen G.; Beyer, Nina

doi:10.1080/13607863.2015.1063108

Cited by 31 publications

(28 citation statements)

References 43 publications

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“…The participants were given instructions to complete the test as quickly and safely as possible [23][24][25].…”

Section: Test Of Physical Performancementioning

confidence: 99%

“…The 30-s chair stand test (STS) assesses strength and endurance in the lower extremity by measuring the number of stands completed in 30 seconds with hands crossed against the chest [25,26].…”

Section: Test Of Physical Performancementioning

confidence: 99%

“…The participants were not instructed to prioritize neither the gait nor the cognitive task [10,25,29]. …”

Section: Test Of Dual-task Performancementioning

confidence: 99%

“…The 10-m walk test (usual gait speed) assesses usual gait speed (m/s) on a 10-m long course [10,25,29]. …”

Section: Test Of Physical Performancementioning

confidence: 99%

See 3 more Smart Citations

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

Sobol

Hoffmann

Frederiksen

et al. 2016

Alzheimer's & Dementia

Self Cite

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“…The participants were given instructions to complete the test as quickly and safely as possible [23][24][25].…”

Section: Test Of Physical Performancementioning

confidence: 99%

Section: Test Of Physical Performancementioning

confidence: 99%

See 2 more Smart Citations

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

Sobol

Hoffmann

Frederiksen

et al. 2016

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, in an effort to arrest the decline in cognitive function (CF) and loss of activities of daily living, nonpharmacological approaches have been investigated. In the randomized clinical trial "Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study," we analyzed the effect of 16 weeks moderate-to high-intensity physical exercise (EXE) in patients with AD on a cognitive [7], functional [8], and molecular level [9]. Despite some effect on clinical symptoms such as processing speed and neuropsychiatric symptoms [7], we found no effect of EXE on levels of Ab, tau, and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) [9].…”

Section: Introductionmentioning

confidence: 99%

[P3–174]: EFFECT OF PHYSICAL EXERCISE ON MARKERS OF NEURONAL DYSFUNCTION IN CEREBROSPINAL FLUID IN PATIENTS WITH ALZHEIMER's DISEASE

Jensen

Portelius

Høgh

et al. 2017

Alzheimer's & Dementia

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Introduction: Physical exercise has gained increasing focus as a potential mean to maintain cognitive function in patients with Alzheimer's disease (AD). Alongside the markers of specific AD pathology (amyloid b and tau), other pathologies such as neuronal damage and synaptic loss have been proposed as markers of the disease. Here, we study the effect of physical exercise on biomarkers of neuronal and synaptic integrity. Methods: Cerebrospinal fluid (CSF) from 51 AD subjects who participated in the randomized controlled trial Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) was analyzed for the concentration of neurofilament light (NFL), neurogranin (Ng), visinin-like protein-1 (VILIP-1), and chitinase-3-like protein 1 (YKL-40). Participants were subjected to either 16 weeks of moderate-to highintensity exercise (n 5 25) or treatment as usual (control group, n 5 26), and CSF was collected before and after intervention. Results: No significant differences in CSF concentrations of VILIP-1, YKL-40, NFL, and Ng were observed when comparing mean change from baseline between the exercise and control groups. Similarly, when classifying subjects based on their exercise levels, no significant changes were observed for the biomarkers in the control group compared with the high-exercise group (attending 80% of the exercise sessions with an intensity of 70% of maximum heart rate or above). Discussion: These results are not supportive of a modulatory effect of physical exercise on the selected biomarkers of neuronal and synaptic integrity in patients with AD.

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Muscle weakness and functional disability in patients with myasthenia gravis

2018

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Introduction: Muscle weakness and functional disability have not been evaluated in a population-based study of patients with myasthenia gravis (MG). Methods: All patients with MG in a well-defined catchment area were identified in the Danish National Patient Registry. Of the 175 eligible patients, 90 participated and were studied using MG-specific scales, isometric dynamometry, and functional tests. Fifty age-and sex-matched subjects served as controls. Results: Muscle strength was reduced by 13%, 21%, and 12% for shoulder abduction, knee extension, and ankle extension, respectively (P < 0.05). Chair stand and 400-meter walking were impaired by 24% and 23%, respectively (P < 0.05). Muscle strength and functional performances were related to MG-specific scales. Discussion: MG patients have moderately reduced isometric muscle strength and impaired physical performance. Muscle weakness and functional tests relate closely to MG-specific scales, suggesting that dynamometry and functional tests can be used to monitor MG patients and as efficacy parameters in clinical trials.

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Associations between physical function, dual-task performance and cognition in patients with mild Alzheimer's disease

Abstract: The evidence of the associations between physical function, dual-task performance and cognition is important when creating new rehabilitation interventions to patients with mild AD.

Cited by 31 publications

References 43 publications

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

[P3–174]: EFFECT OF PHYSICAL EXERCISE ON MARKERS OF NEURONAL DYSFUNCTION IN CEREBROSPINAL FLUID IN PATIENTS WITH ALZHEIMER's DISEASE

Muscle weakness and functional disability in patients with myasthenia gravis

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