Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans

Fletcher, Tony; Galloway, Tamara S.; Melzer, David; Holcroft, Paul; Cipelli, Riccardo; Pilling, Luke C.; Mondal, Debapriya; Luster, Michael I.; Harries, Lorna W.

doi:10.1016/j.envint.2013.03.008

Cited by 145 publications

(83 citation statements)

References 28 publications

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“…These data do not support a strong role for plasma lipoprotein fractions in explaining the inconsistent dose-response associations. Fletcher et al (2013) presented the first evidence from a human population that PFOA and PFOS were associated with alterations in the levels of several gene transcripts involved in cholesterol transport. Their data were consistent with exposure to PFOA or PFOS contributing to elevated cholesterol, which has the potential to explain some of the epidemiological observations that have been reported for these compounds.…”

Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tPerfluoroalkyl acids (PFAAs) have been used in a variety of products for many years and have been detected worldwide in human serum. Previous studies have suggested the potential effects of PFAAs on serum lipids. To investigate the associations between serum concentrations of PFAAs and serum lipid levels, 133 participants were randomly selected from the people coming for health check-up in Yuanyang Red Cross Hospital of Henan, China. Linear regression analysis revealed that perfluoro-octanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), with a median concentration of 1.43, 0.37, and 0.19 ng/mL, respectively, were positively associated with total cholesterol (TC). Those in the highest quartile of PFOA exposure had ln-TC levels 0.24 mmol/L higher than those in the lowest quartile. For PFNA and PFDA, effect estimates were 0.25 and 0.16 mmol/L, respectively. A positive association between high-density lipoprotein cholesterol (HDLC) and PFDA was found, and there was a 0.18 mmol/L increase of HDLC for the top PFDA quartile compared with the lowest quartile. PFOA and PFNA were positively associated with low-density lipoprotein cholesterol (LDLC). Ln-LDLC levels of people in both top PFOA and PFNA quartiles were 0.33 mmol/L higher than those in the lowest quartiles. Logistic regression analysis indicated that increased PFOA and PFOS quartiles were positively associated with an increased risk of abnormal TC and LDLC when controlling for no confounding factors.

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Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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“…The dose response relationship was, however, considered as tenuous and possibly resulting from inadvertent selection bias [276]. A transcriptional analysis that found changes in the expression of genes related to cholesterol metabolism and suggested that exposure to PFOA may promote a hypercholesterolemic environment [283] was criticized and deemed unsubstantiated [284]. Decrease of LDL cholesterol with decrease in serum PFOA after exposure to contaminated drinking water was ended, indicated a causal relation [285].…”

Section: More Exposed Populationsmentioning

confidence: 99%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

214

120

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“…We believe that the identification of a population around Tangxun Lake with PFAS serum concentrations ranging over 4 orders of magnitude and a clearly defined exposure source will probably help to resolve controversial epidemiological findings of PFASs. 25,60 ■ ASSOCIATED CONTENT * S Supporting Information Additional information regarding chemicals and materials, sampling, sample pretreatment, quality assurance and quality control, blood clinical chemistry detection, data description and statistical analyses, Tables S1−S11, and Figures S1−S3. This material is available free of charge via the Internet at http:// pubs.acs.org/.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…Previous studies have also reported inconsistent associations between clinical biomarkers, and PFAS exposure may to a large extent be explained by different study designs. 25,60 More carefully designed prospective studies including a larger number of individuals should, therefore, be performed to evaluate the human health risks associated with PFAS exposure around Tangxun Lake.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Highly Elevated Serum Concentrations of Perfluoroalkyl Substances in Fishery Employees from Tangxun Lake, China

Zhou

Shi

Vestergren

et al. 2014

Environ. Sci. Technol.

143

117

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Increasing production and use of per-and polyfluoroalkyl substances (PFASs) has been reported from China, and a few studies have shown there are subpopulations in China with high and increasing exposure to these chemicals. In this paper, we present a comprehensive exposure assessment of PFASs in fishery employees from Tangxun Lake, China. Exceptionally high serum concentrations of C4 to C12 PFASs were observed in fishery employees (n = 39, median perfluorooctanesulfonic acid (PFOS) 10 400 ng/mL) compared to a reference group from the same city (n = 9, median PFOS 18.7 ng/mL). On the basis of the comparison of different exposure pathways, it was concluded that contaminated fish from Tangxun Lake was the primary source of PFAS exposure to fishery employees, and there was a positive association between serum PFAS concentrations and time of employment in the fishery. PFOS isomer profiles in fishery employees showed a significantly higher proportion of linear PFOS (78.4%) compared to the background-exposed reference group (66.8%), reflecting the highly linear PFOS isomer profile (>90%) of lake fish. Median renal clearance rates (CL renal ) of C4 to C10 perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkanesulfonic acids (PFSAs) ranged from 0.020 to 16.5 mL/day/kg and 0.013 to 9.43 mL/day/kg, respectively. PFCAs with less than eight perfluoroalkyl carbons were primarily eliminated via urine, whereas other routes of excretion may have contributed to the elimination for long-chain PFCAs and PFSAs. Calculated daily PFOS exposures of fishery employees significantly exceeded tolerable daily intake limits, but clinical blood chemistry parameters were mostly within normal reference ranges. However, additional epidemiological studies are needed to address potential associations between PFAS exposure and health effects in the Tangxun Lake area.

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Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans

Cited by 145 publications

References 28 publications

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Per- and polyfluorinated substances (PFASs): Environmental challenges

Highly Elevated Serum Concentrations of Perfluoroalkyl Substances in Fishery Employees from Tangxun Lake, China

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