Associations between Perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study

Webster, Glenys M.; Venners, Scott A.; Mattman, André; Martin, Jonathan W.

doi:10.1016/j.envres.2014.06.012

Cited by 113 publications

(97 citation statements)

References 61 publications

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“…Developmental neurotoxicity may also be mediated by PBDEs’ and PFASs’ effects on thyroid hormones, which are essential for proper brain development (Williams, 2008). Several epidemiologic studies have reported that prenatal concentrations of PBDEs and PFASs disrupt thyroid hormones (Abdelouahab et al, 2013; Chevrier et al, 2010; Stapleton et al, 2011; Vuong et al, 2015; Wang et al, 2014; Webster et al, 2014). We previously observed a significant association between prenatal PBDEs and higher maternal serum thyroxine (T 4 ) and triiodothyronine (T 3 ) in the HOME Study (Vuong et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children

Vuong

Yolton

Webster

et al. 2016

Environmental Research

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Executive function is a critical behavioral trait rarely studied in relation to potential neurotoxicants. Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) has been associated with adverse neurodevelopment, but there is limited research on executive function. Data from 256 mother-child pairs in the Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine maternal serum PBDEs and PFASs and executive function in children ages 5 and 8 years. Maternal serum PBDEs and PFASs were measured at 16±3 weeks gestation. Executive function was assessed with the parent-rated Behavior Rating Inventory of Executive Function (BRIEF), which yields composite measures: behavioral regulation index, metacognition index, and global executive composite. Higher BRIEF scores indicate executive function impairments. Linear mixed models and generalized estimating equations were used to estimate covariate-adjusted associations between PBDEs and PFASs and executive function. A 10-fold increase in BDE-153 was associated with poorer behavior regulation (β=3.23, 95% CI 0.60, 5.86). Higher odds of having a score ≥60 in behavior regulation (OR=3.92, 95% CI 1.76, 8.73) or global executive functioning (OR=2.34, 95% CI 1.05, 5.23) was observed with increased BDE-153. Each ln-unit increase in perfluorooctane sulfonate (PFOS) was associated with poorer behavior regulation (β=3.14, 95% CI 0.68, 5.61), metacognition (β=3.10, 95% CI 0.62, 5.58), and global executive functioning (β=3.38, 95% CI 0.86, 5.90). However, no association was observed between perfluorooctanoate (PFOA) and executive function. Prenatal exposures to BDE-153 and PFOS may be associated with executive function deficits in school-age children.

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Section: Discussionmentioning

confidence: 99%

Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children

Vuong

Yolton

Webster

et al. 2016

Environmental Research

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“…We re-ran the final models using maternal urinary BPA concentrations without creatinine-standardization to determine whether our method for accounting for urine dilution altered our results. We also examined whether compromised thyroid function modifies the association between BPA and THs (Webster et al, 2014). Very few women had clinically significant elevations in thyroid antibody [TPOAb >9.0 IU/mL (n=15); TgAb >2.0 IU/mL (n=5)].…”

Section: Methodsmentioning

confidence: 99%

Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: The HOME Study

Romano

Webster

Vuong

et al. 2015

Environmental Research

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106

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Bisphenol A (BPA), an endocrine disruptor used in consumer products, may perturb thyroid function. Prenatal BPA exposure may have sex-specific effects on thyroid hormones (THs). Our objectives were to investigate whether maternal urinary BPA concentrations during pregnancy were associated with THs in maternal or cord serum, and whether these associations differed by newborn sex or maternal iodine status. We measured urinary BPA concentrations at 16 and 26 weeks gestation among pregnant women in the HOME Study (2003–2006, Cincinnati, Ohio). Thyroid stimulating hormone (TSH) and free and total thyroxine (T4) and triiodothyronine (T3) were measured in maternal serum at 16 weeks (n=181) and cord serum at delivery (n=249). Associations between BPA concentrations and maternal or cord serum TH levels were estimated by multivariable linear regression. Mean maternal urinary BPA was not associated with cord THs in all newborns, but a 10-fold increase in mean BPA was associated with lower cord TSH in girls (percent change= −36.0%; 95% confidence interval (CI): −58.4, −1.7%), but not boys (7.8%; 95% CI: −28.5, 62.7%; p-for-effect modification=0.09). We observed no significant associations between 16-week BPA and THs in maternal or cord serum, but 26-week maternal BPA was inversely associated with TSH in girls (−42.9%; 95% CI: −59.9, −18.5%), but not boys (7.6%; 95% CI: −17.3, 40.2%; p-for-effect modification=0.005) at birth. The inverse BPA-TSH relation among girls was stronger, but less precise, among iodine deficient versus sufficient mothers. Prenatal BPA exposure may reduce TSH among newborn girls, particularly when exposure occurs later in gestation.

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“…Chemicals, Health and Pregnancy study conducted among pregnant women of Vancouver Canada (n=152) reported a positive association between PFNA and TSH. Among TPOAb abnormal group, PFASs showed positive associations with TSH, and negative associations with fT435). In a mother and child cohort of Norway, PFASs such as perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnDA) showed also negative associations with T3, and PFOS showed a positive association with TSH36).…”

Section: Pfass Exposure and Thyroid Hormone Disruption In Susceptiblementioning

confidence: 95%

Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications

Lee

Choi

2017

Ann Pediatr Endocrinol Metab

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Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Due to their unique physicochemical characteristics, PFASs have been used as surfactants and surface coating materials in many applications. Therefore, PFASs have been frequently detected in humans and environment worldwide. In cross-sectional studies using nationally representative general human populations of United States, several PFASs have shown significant associations with thyroid hormones. Moreover, among pregnant women and their infants, not only major PFASs such as perfluorooctane sulfonic acid and perfluorooctanoic acid, but also those with shorter or longer carbon chains showed significant associations with thyroid hormones. Often demographic characteristics such as sex, age, and disease status appear to influence the associations between PFASs exposure and thyroid hormones. In general, major PFASs showed hypothyroidism effects among pregnant women and infants. As 8 carbon based PFASs have been phased out, those with shorter or longer carbon chains have been used in growing amount as replacement. However, only limited information is available for their occurrences and toxicity among humans. Further investigations on these substituting PFASs are required. In addition, efforts are warranted to identify sources of and mitigate exposure to these thyroid disrupting chemicals especially during pregnancy and early stages of life.

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Associations between Perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study

Cited by 113 publications

References 61 publications

Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children

Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children

Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: The HOME Study

Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications

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