Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study

Gløersen, Marthe; Pettersen, P. Steen; Neogi, Tuhina; Sexton, Joseph; Kvien, Tore K; Hammer, Hilde Berner; Haugen, I.K.

doi:10.1016/j.joca.2023.07.005

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…On the other hand, the presence of NP did not affect the efficacy of prednisolone against inflammatory pain [ 10 ]. In addition, lower pressure pain threshold (PPT)—indicating pain sensitization, measured at the most painful interphalangeal finger joint with a digital handheld algometer—has been associated with more tender and painful hand joints in a cohort of 206 patients affected by hand OA (mean age 61 (57–66) years, mean BMI 26.4, median disease duration 6 years) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Neuropathic Pain in Erosive Hand Osteoarthritis

Favero,

Cacciavillani,

Ometto

et al. 2024

JCM

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Background/Objectives: Erosive hand osteoarthritis (EHOA) is an aggressive form of hand osteoarthritis (OA) and a severely disabling condition. Patients affected by OA frequently lament symptoms suggestive of neuropathic pain (NP). The aim of our study was to ascertain the presence and severity of NP in patients with EHOA and correlate its presence with EHOA clinical characteristics. Methods: In this retrospective study, we included all consecutive EHOA patients with NP symptoms who underwent upper limb electroneurography (ENoG) and nerve ultrasound. The presence of NP was screened using the ID pain neuropathic pain-screening questionnaire (ID-Pain). In addition, the following NP questionnaires were also used: Douleur Neuropathique en 4 Questions (DN4), PainDETECT, and Neuropathic Pain Symptom Inventory (NPSI). Moreover, patients completed the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and Dreiser’s algofunctional finger index questionnaires assessing EHOA disease activity. The following clinical and laboratory data were collected: age, sex, BMI, disease duration, intensity of pain (VAS 0–10), painful and swollen joints, and inflammatory indices, as well as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Results: Of the 34 patients studied, 24 (70.6%) presented NP to the ID-Pain questionnaire. According to DN4, 14 (41.2%) patients had NP, while using the PainDETECT questionnaire, 67.6% had NP. Patients with NP were statistically younger and had a higher VAS pain score compared to subjects without NP. The ENoG and median nerve ultrasound were normal in 81% of patients, while four patients had carpal tunnel syndrome. The ID-Pain questionnaire correlated with the number of painful joints (r = 0.48, p = 0.03) and with the AUSCAN questionnaire (r = 0.37, p = 0.05). The DN4 questionnaire correlated with PainDETECT (r = 0.58, p < 0.01). The PainDETECT questionnaire correlated with VAS pain (r = 0.49, p = 0.02), the DN4 questionnaire (r = 0.58, p < 0.01), and AUSCAN (r = 0.51, p = 0.02). The NPSI questionnaire correlated negatively with BMI (r = −0.53, p = 0.01) and positively with the PainDETECT questionnaire (r = 0.49, p = 0.02). Conclusions: Our study revealed that 32% to 70% of EHOA patients exhibited symptoms consistent with NP, with observed variability depending on the questionnaire utilized. Despite patients frequently exhibiting symptoms compatible with NP, only 19% of patients presented alterations on ENoG and ultrasound examinations confirming CTS. This suggests a probable nociplastic component for pain in patients with EHOA, which warrants tailored treatment. In the present study, NP correlated with clinical and functional indices of EHOA.

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Section: Introductionmentioning

confidence: 99%

Assessment of Neuropathic Pain in Erosive Hand Osteoarthritis

Favero,

Cacciavillani,

Ometto

et al. 2024

JCM

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Nor-Hand-Study: Schmerzsensibilisierung und körperliche Funktion bei Arthrose

2024

Aktuelle Rheumatologie

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Eine Arthrose in den Händen ist für die Betroffenen mit erheblichen Einschränkungen und Schmerzen verbunden. Derzeit verfügbare Behandlungsmethoden können die Schmerzen oft nur begrenzt lindern. M. Gløersen und Kollegen prüften im Rahmen der Nor-Hand-Study nun, ob ein Zusammenhang zwischen Schmerzsensibilisierung und der Funktion der Hand und der unteren Extremitäten bei Menschen mit Arthrose in den Händen (OA) besteht.

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Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study

Cited by 2 publications

References 42 publications

Assessment of Neuropathic Pain in Erosive Hand Osteoarthritis

Assessment of Neuropathic Pain in Erosive Hand Osteoarthritis

Nor-Hand-Study: Schmerzsensibilisierung und körperliche Funktion bei Arthrose

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