Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients

Kruiper, Caitlyn; Fagerlund, Birgitte; Nielsen, Mette Ødegaard; Düring, Signe; Jensen, Mads Hashiba; Ebdrup, Bjørn H; Glenthøj, Birte; Oranje, Bob

doi:10.1017/s0033291718001575

Cited by 20 publications

(25 citation statements)

References 45 publications

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“…These results, in part, agree with Mathalon et al (2000) that P3a and P3b tracked illness duration longitudinally or across different stages of illnesses (Jahshan et al, 2012a). However, when examining data longitudinally, we found that patients already showed impairment at baseline and this deficit was stable over time, similar to previous reports (del Hermens et al, 2010;Jahshan et al, 2012a;Kruiper et al, 2018;Morales-Muñoz et al, 2017). A similar pattern of results was found with P3a amplitude, suggesting P3a deficits are already present at a first episode, substantiating other reports (Brown et al, 2002;de Wilde et al, 2008;del Re et al, 2015;Demiralp et al, 2002;Devrim-Üçok et al, 2016Devrim-Üçok et al, , 2006Hirayasu et al, 1998;Kruiper et al, 2018;Morales-Muñoz et al, 2017;Renoult et al, 2007;Salisbury et al, 1998;Sumich et al, 2006;Umbricht et al, 2006).…”

Section: Discussionsupporting

confidence: 92%

“…Psychopathology severity and antipsychotic medications were unrelated to P3 amplitude effect size (Polich and Jeon, 2003). Patients with first episode psychosis (FEP) and individuals at ultra high risk for psychosis also show amplitude reductions (Brown et al, 2002;de Wilde et al, 2008;del Re et al, 2015;Devrim-Üçok et al, 2006;Hirayasu et al, 1998;Kruiper et al, 2018;Morales-Muñoz et al, 2017;Renoult et al, 2007;Salisbury et al, 1998;Sumich et al, 2006;Umbricht et al, 2006;van Tricht et al, 2011). A meta-analysis of P3b found a reduction of amplitude in unaffected relatives of patients as compared to controls with a moderate pooled standardized effect size of 0.61 (Bramon et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies found reduced P3a amplitude in chronic SZ (Devrim-Üçok et al, 2006;Hamilton et al, 2018;Jahshan et al, 2012a;Kirihara et al, 2009;Mathalon et al, 2000;Pfefferbaum et al, 1989;Rissling et al, 2012) as well as in FEP patients (del Re et al, 2015;Hermens et al, 2010;Jahshan et al, 2012a;Kaur et al, 2011;Kruiper et al, 2018;Morales-Muñoz et al, 2017), suggesting that P3a deficit is already present at an early stage. The N1 and P2 ERPs reflect perceptual information registration and processing (Dien et al, 2004;Picton and Hillyard, 1974).…”

Section: Introductionmentioning

confidence: 99%

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A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients

Monaghan

Brickman

Huynh

et al. 2019

International Journal of Psychophysiology

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Background-Deficits in auditory event-related potentials (ERPs), brain responses to stimuli indexing different cognitive processes, have been demonstrated widely in chronic schizophrenia (SZ) patients though much less is known about these responses across the early course of psychosis. The present study examined multiple ERP components in first episode psychosis (FEP) patients longitudinally and investigated the relationships between ERPs, psychosocial functioning, and clinical features over time. Methods-N1, P2, P3a, and P3b ERPs were elicited using a three-stimulus (novelty) auditory oddball paradigm. FEP patients included SZ-spectrum and psychotic bipolar disorder (BD) diagnoses. Data were collected from 41 patients at baseline, 20 patients at 12-month follow-up, 14 at 24-month follow-up, and 29 healthy control subjects. Results-N1 and P2 ERPs were intact across the early stages of psychosis. Baseline P2 was significantly larger in BD than SZ patients. Reduced P3a and P3b ERPs were found in patients followed longitudinally and are stable over time. ERPs tracked distinct aspects of symptomology and medication, though specific associations were inconsistent across time. Baseline P3a amplitude predicted later psychosocial functioning. The pattern of correlations between ERP components in patients differed from controls.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients

Monaghan

Brickman

Huynh

et al. 2019

International Journal of Psychophysiology

View full text Add to dashboard Cite

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“…In FEP and FES subjects, as compared to HCs, different studies have highlighted a decrease of the P3b amplitude (67, 163,164,172,199,210,213,[215][216][217][218][219][220][221][222][223]. One study demonstrated that deficits in P3b, as observed for P3a, were not present at baseline, but emerged when FEP subjects were evaluated at 12-and 24month follow-up visits (166).…”

Section: P3bmentioning

confidence: 99%

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.

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“…Note that ROCFT requires a finer and longer time as a visual working memory task than CANTAB SWM, and TMT B requires more complex executive functioning using the numbers and alphabet character, compared with CANTAB IED using only simple figures. In RTI simple and five-choice reaction and movement time, there were fewer previous studies with inconsistent results in the patients [41,42]. Our RTI results suggest that the reaction and movement times of the patients were impaired in the more complex tasks than the simplified ones.…”

Section: Plos Onementioning

confidence: 47%

Cognition and interpersonal coordination of patients with schizophrenia who have sports habits

et al. 2020

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Team sports activities are effective for improving the negative symptoms and cognitive functions in patients with schizophrenia. However, the interpersonal coordination during the sports and visual cognition of patients with schizophrenia who have team sports habits are unknown. The main objectives of this study were to test two hypotheses: first, patients with schizophrenia perform the skill requiring ball passing and receiving worse than healthy controls; and second, the patients will be impaired in these functionings in accordance with the previous studies regarding schizophrenia in general. Twelve patients with schizophrenia and 15 healthy controls, who had habits in football, participated in this study. The participants performed three conventional cognitive tests and a 3-vs-1 ball possession task to evaluate their interpersonal coordination. The results showed that in the 3-vs-1 possession task, the displacement in the pass angle for the patients was significantly smaller than that for the control. The recall in the complex figure test, the performance in the trail making test, and that in the five-choice reaction task for the patients were worse than those for the control. Moreover, we found the significant partial correlations in the patients between the extradimensional shift error and the pass angle as well as between the time in the trail making test and the displacement in the pass angle, whereas there was no significant correlation in the control group. This study clarified the impaired interpersonal coordination during team sports and the visual cognition of patients with schizophrenia who have team sports habits.

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Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients

Cited by 20 publications

References 45 publications

A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients

A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

Cognition and interpersonal coordination of patients with schizophrenia who have sports habits

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