Associations between obstructive sleep apnea severity and endoscopically proven gastroesophageal reflux disease

Kim, Youlim; Lee, Yeon Joo; Cho, Young Jae; Yoon, Ho Il; Lee, Jae-Ho; Lee, Choon Taek; Kim, Sejoong

doi:10.1007/s11325-017-1533-2

Cited by 25 publications

(36 citation statements)

References 27 publications

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“…The etiology of symptoms may be multifactorial for patients with concomitant LPR and obstructive sleep apnea syndrome, based on recent data that supported a strong association between obstructive sleep apnea syndrome severity and reflux symptoms. 28…”

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Lechien¹,

Akst

Hamdan

et al. 2019

Otolaryngol.--head neck surg.

266

401

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Objective To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources PubMed, Cochrane Library, and Scopus. Methods A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature. Conclusions The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance–pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved. Implications for Practice The development of multichannel intraluminal impedance–pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.

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Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Lechien¹,

Akst

Hamdan

et al. 2019

Otolaryngol.--head neck surg.

266

401

View full text Add to dashboard Cite

show abstract

“…Kim et al ascertained that esophagogastroduodenoscopy-proven GERD was significantly associated with OSA, which substantiates our study’s results. A recurrent upper airway narrowing among OSA patients during sleep could result in negative intra-thoracic pressure during inspiration [32]. The increased intrathoracic pressure might facilitate acid reflux into the esophagus, which finally leads to GERD [32].…”

Section: Discussionmentioning

confidence: 99%

“…A recurrent upper airway narrowing among OSA patients during sleep could result in negative intra-thoracic pressure during inspiration [32]. The increased intrathoracic pressure might facilitate acid reflux into the esophagus, which finally leads to GERD [32]. GERD could deteriorate OSA by aggravating the airway resistance by causing posterior laryngitis [32].…”

Section: Discussionmentioning

confidence: 99%

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Magnitude and Determinants of Patients at Risk of Developing Obstructive Sleep Apnea in a Non-Communicable Disease Clinic

Mathiyalagen

Govindasamy²,

Rajagopal

et al. 2019

Medicina

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Background and Objective: Obstructive sleep apnea (OSA) is a common chronic disorder worldwide, which can adversely affect the cardiovascular system among non-communicable disease (NCD) patients. It is underdiagnosed—or rather not diagnosed—in primary care settings due to the costly diagnostic techniques involved. This study aimed to assess the number of study participants at risk of developing OSA and to assess and quantify the risk factors associated with this disorder. Materials and Methods: A cross-sectional study was performed in an NCD clinic of a rural health training center, Karikalampakkam, Puducherry of South India from August 2018 to October 2018. A Modified Berlin Questionnaire (MBQ) was used to screen the study participants at risk for OSA. Four-hundred-and-seventy-three people aged 18 years and above were included in the study, using systematic random sampling. Respondents’ socio-demographic and morbidity characteristics, as well as clinical and anthropometric parameters including body weight, height, blood pressure, neck, hip and waist circumference were collected. Data was captured using Epicollect5 and analyzed using SPSS version 20.0. Results: One-fourth (25.8%) of the respondents were at high risk of developing OSA. In terms of gender, 27.9% of the men and 23.8% of the women were at high risk for OSA. In univariate analyses, the risk of developing OSA was significantly associated with a history of diabetes mellitus, hypertension, dyslipidemia and gastro-esophageal reflux disease, weight, body mass index, neck, waist and hip circumference, waist–hip ratio, and systolic and diastolic blood pressure. Multivariate logistic regression analysis showed that a history of dyslipidemia (aOR, 95% CI = 2.34, 1.22–4.48), body mass index (aOR, 95% CI = 1.15, 1.06–1.22) and waist circumference (aOR, 95% CI = 1.10, 1.07–1.14) emerged as significant predictors of risk for OSA. Conclusions: A considerable proportion of NCD patients with easily detectable attributes are at risk of developing OSA, but still remain undiagnosed at a primary health care setting. The results obtained using MBQ in this study were comparable to studies performed using polysomnography. Dyslipidemia, body mass index and waist circumference were independent risk factors for predicting a risk of developing OSA. Prospective studies are needed to confirm whether a reduction in these risk factors could reduce the risk for OSA.

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“…Furthermore, more studies are using polysomnography to document apnea index and 24-h pH monitoring to document the acid reflux and the prevalence of GERD in OSAHS patients. Kim et al [ 10 ] found GERD was associated with more severe OSAHS and GERD symptoms were also associated with deteriorated sleep quality. However, this pathophysiological mechanism has been questioned in some studies as they find negative results.…”

Section: Introductionmentioning

confidence: 99%

The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis

Yang

Niu

et al. 2018

Sleep Breath

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Associations between obstructive sleep apnea severity and endoscopically proven gastroesophageal reflux disease

Abstract: Endoscopically proven GERD was associated with more severe OSA. GERD symptoms were also associated with deteriorated sleep quality.

Cited by 25 publications

References 27 publications

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Magnitude and Determinants of Patients at Risk of Developing Obstructive Sleep Apnea in a Non-Communicable Disease Clinic

The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis

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