Associations between neonatal serum bilirubin and childhood hypertension

Yu, Huiyang; Zou, Lile; He, Yuan; Luo, Lijuan; Dong, Wei; Zhang, Yongjun; Lei, Xiaoping

doi:10.1371/journal.pone.0219942

Cited by 5 publications

(7 citation statements)

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“…Yasuko Takeda et al selected 37 patients with pulmonary arterial hypertension (PAH) as the research objects and manifested that elevated serum bilirubin is a risk factor for death in patients with PAH [ 18 ]. Beyond that, according to the research of 37,544 newborns (31,819 term and 5725 preterm births) from the U.S. Collaborative Perinatal Project conducted from 1959 to 1965, Huan Yu et al proposed that neonatal serum bilirubin levels at 48 h after birth were positively associated with childhood blood pressure/hypertension in the preterm infants at 7 years [ 19 ]. However, other experts offered diverse perspectives that high serum bilirubin may decrease hypertensive risk.…”

Section: Discussionmentioning

confidence: 99%

“…As a lipophilic molecule, UCB is able to bind to human neurons, which is enriched in phospholipids. While the excitability of sympathetic nervous system exhibited a positive relationship with the bilirubin deposited in the central nervous system, which matters in the hypertensive pathogenesis [ 19 , 43 ]. In contrast, CB presented the inverse effect as UCB, which can be plausibly interpreted by its chemical properties of water-soluble and urinary ready excretion.…”

Section: Discussionmentioning

confidence: 99%

“…Until now, some epidemiological studies have aimed to uncover the relationship between bilirubin and BP among children and middle-age adults. However, very limited studies have been conducted among the ageing population, especially in China [ 19 – 21 ]. Given the potential indication of bilirubin towards hypertension, we aimed to examine the association between the baseline levels of bilirubin and the incident risk of hypertension with the adjustments for key covariates on the dataset of the Guankou Ageing Cohort Study (GACS).…”

Section: Introductionmentioning

confidence: 99%

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The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

et al. 2022

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Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

et al. 2022

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“…Поиск предикторов АГ осуществляется на разных этапах онтогенеза человека, начиная с перинатального периода. Показано, что преэклампсия и преждевременные роды связаны с высоким риском развития у ребенка в будущем АГ и ССЗ [35], как и низкий вес ребенка при рождении [36,37] и уровень билирубина в плазме крови новорожденных [38]. Также повышение артериального давления в пубертатном периоде является предиктором АГ у взрослых [39].…”

Section: причины развития агunclassified

Preclinical predictors of arterial hypertension

Дороговцев

Симоненко

2021

jour

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Arterial hypertension (AH) remains one of the most common diseases and a leading risk factor for cardiovascular diseases (CVD) in the 21st century. It determines the importance of a search for new factors provoking an increase in blood pressure. This review focuses on studies of preclinical predictors of hypertension. Orthostatic circulatory disorders with clinical signs of cardiovascular deconditioning are risk factors for the development of hypertension and CVD, accompanied by a more rapid increase in vascular stiff ness. Such abnormalities, even minor ones without clinical manifestations, increase the risk of hypertension development in the young population. The review deals with orthostatic changes in hemodynamics and features of neurohormonal change. It has been shown that adaptive processes counteracting an increase in hydrostatic pressure contribute to a significant transient increase in vascular stiff ness. The evolution of orthostatic hemodynamic disorders from preclinical to clinical forms accelerates the process of vascular wall remodeling, leading to a spontaneous increase in its rigidity — one of the significant risk factors for hypertension and CVD. To identify preclinical predictors, a new protocol of passive orthostatic test (POT) was developed. It was standardized not by the tilt angle, but by the height of the hydrostatic column. Further research is needed to evaluate the prognostic capabilities of predictors, to reveal the pathogenetic connection of orthostatic disorders with the development of hypertension, and to remodeling the vascular wall, which causes an increase in its rigidity. It is also required to search for ways to correct preclinical orthostatic disorders in healthy young population for early prevention of hypertension.

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“…The main clinical focus has generally been on the damage of bilirubin to the central nervous system and the induction of bilirubin encephalopathy (2,3). In-depth research has revealed that HBN affects myocardial contractility, and this effect of bilirubin increases attention (4).…”

Section: Introductionmentioning

confidence: 99%

Early changes in left ventricular myocardial function by 2D speckle tracking layer-specific technique in neonates with hyperbilirubinemia

Chen¹,

Zhang²,

Fang³

et al. 2022

Quant Imaging Med Surg

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Background: Hyperbilirubinemia (HBN) can cause myocardial injury in neonates. Advancement in myocardial deformation imaging allows the detection of subclinical changes in myocardial contractility.The present study aimed to evaluate the changes in left ventricular contractility in newborns with hyperbilirubinemia by 2D speckle tracking imaging (STI).Methods: A group of 134 neonates who reached the diagnostic level of HBN as the HBN group was selected. The control group included 56 healthy newborns. The interventricular septum, anterior partition, anterior wall, sidewall, posterior wall, and inferior wall were separated into the basal, middle, and apical segments. In each segment, speckle tracking analysis was performed in the subintimal, middle, and subadventitial myocardium. The overall longitudinal strain of the myocardium in different ventricular walls and segments and global longitudinal strain (GLS) were computed. At the same time, the laboratory results of blood gas analysis, blood routine tests, liver function, and myocardial enzyme spectrum in HBN neonates were collected and correlated with the left ventricular stratified strain parameters.Results: The gradient of the left ventricular GLS had the same characteristics in both groups of newborns.There was a decreasing trend of longitudinal strain (LS) from the intima to the adventitia (i.e., GLSendo > GLSmid > GLSepi). This gradient was also present in stratified LS in each myocardial segment (P<0.001).The LS showed an increasing trend from the basal to the apical segment (P<0.001). The LS of the ventricular septum, anterior wall (or anterior septum), inferior wall, lateral wall, and posterior wall showed a decreasing trend (P<0.001). Stratified strain parameters of the ventricular wall (i.e., the 3-layer myocardium: LSendo-SEPT, LSmid-SEPT, and LSepi-SEPT) were all significantly lower in the HBN group than in the control group (P=0.

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Associations between neonatal serum bilirubin and childhood hypertension

Cited by 5 publications

References 46 publications

The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

Preclinical predictors of arterial hypertension

Early changes in left ventricular myocardial function by 2D speckle tracking layer-specific technique in neonates with hyperbilirubinemia

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