Associations Between Muscle Quality and Cognitive Function in Older Men: Cross-Sectional Data From the Geelong Osteoporosis Study

Sui, Sophia X.; Williams, Lana J.; Holloway‐Kew, Kara L; Hyde, Natalie K.; Leach, Sarah; Pasco, Julie A.

doi:10.1016/j.jocd.2021.03.007

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…This response in Snell dwarf mice was accompanied by remodeling in VCAM-1 protein levels and muscle fiber MHC isoform distribution thereby indicating these responses as possibly compensatory when anterior pituitary hormones are deficient. Overall, the results Based on associations observed between muscle quality and mortality as well as other age-dependent health outcomes, some have proposed that muscle quality is crucial for wellbeing throughout life [19][20][21]. Given this context, the finding of poor muscle quality and performance in general at baseline for the long-lived Snell dwarf mice even at young age in the present study could be considered unexpected.…”

Section: Discussionmentioning

confidence: 56%

“…Based on associations observed between muscle quality and mortality as well as other age-dependent health outcomes, some have proposed that muscle quality is crucial for wellbeing throughout life [ 19 – 21 ]. Given this context, the finding of poor muscle quality and performance in general at baseline for the long-lived Snell dwarf mice even at young age in the present study could be considered unexpected.…”

Section: Discussionmentioning

confidence: 99%

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Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1dw/dw) mouse

Rader

Naimo

Ensey

et al. 2022

Aging

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Snell dwarf mice with the Pit1 dw/dw mutation are deficient in growth hormone, prolactin, and thyroid stimulating hormone and exhibit >40% lifespan extension. This longevity is accompanied by compromised muscular performance. However, research regarding young (3-month-old) Snell dwarf mice demonstrate exceptional responsivity to resistance-type training especially in terms of a shifted fiber type distribution and increased protein levels of vascular cell adhesion molecule-1 (VCAM-1), a possible mediator of such remodeling. In the present study, we investigated whether this responsiveness persists at 12 months of age. Unlike 12-month-old control mice, age-matched Snell dwarf mice remained resistant to training-induced maladaptive decreases in performance and muscle mass. This was accompanied by retainment of the remodeling capacity in muscles of Snell dwarf mice to increase VCAM-1 protein levels and a shift in myosin heavy chain (MHC) isoform distribution with training. Even decreasing training frequency for control mice, an alteration which protected muscles from maladaptation at 12 months of age, did not result in the overt remodeling observed for Snell dwarf mice. The results demonstrate a distinct remodeling response to resistance-type exercise operative in the context of the Pit1 dw/dw mutation of long-lived Snell dwarf mice.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1dw/dw) mouse

Rader

Naimo

Ensey

et al. 2022

Aging

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“…Cognitive function was evaluated using a computer-based neuropsychology battery, the CogState Brief Battery (CBB), which has been described previously 13 – 15 . The CBB requires participants to respond to stimuli cards as a part of a detection (DET), identification (IDN), one-card learning (OCL) and one-back (OBK) task that assessed cognitive performance across four domains, namely psychomotor function, visual identification/attention, recognition memory/learning and working memory, respectively.…”

Section: Methodsmentioning

confidence: 99%

Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia

Mehta

Mohebbi

Pasco

et al. 2022

Sci Rep

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Although several genetic polymorphisms have been linked with the risk of Alzheimer’s disease, less is known about their impact on cognitive performance among cognitively healthy individuals. Our aim was to investigate the association of the genetic variant, rs744373 in the bridging integrator 1 gene (BIN1), the strongest genetic risk factor for Alzheimer’s disease after the APOE ε4 allele, with different cognitive domains among non-demented older men. Cognitive function was measured using the CogState Brief Battery, which assessed cognitive performance across four domains: psychomotor function, visual attention, recognition memory and working memory. Linear regression analysis revealed that individuals with the BIN1 risk allele performed poorly on the recognition memory task as compared to those without the risk allele. However, this was in contrast with the individuals who harboured the APOE ε4 risk allele as they displayed better performance on the recognition task in comparison to those without the ε4 risk allele. To the best of our knowledge, this is the first study that demonstrates genetic variation in BIN1 to be a better predictor of recognition memory than APOE, which remains the biggest genetic risk factor for Alzheimer’s disease.

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“…Lower limb muscle quality is calculated as the ratio of quadriceps strength to lean mass in the legs [ 15 ]. Alternatively, muscle quality can be determined through grip strength in relation to appendicular skeletal muscle mass (ASM), that is, the lean mass in both arms and legs [ 16 ]. Among the calculated parameters associated with RMS, grip strength is a frequently used indicator of muscle strength in healthcare settings, and ASM is routinely used to diagnose sarcopenia, making grip strength/ASM a more readily accessible measure for clinical use.…”

Section: Introductionmentioning

confidence: 99%

“…Yoon et al found that the worse the glucose metabolism, the lower the RMS was [ 18 ]. In addition, the higher the RMS, the lower the risk of cognitive impairment in men [ 16 ]. Among patients undergoing dialysis, a lower RMS is an independent predictor of increased mortality [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Association between relative muscle strength and hypertension in middle-aged and older Chinese adults

Luo,

Zhang,

Yang

et al. 2023

BMC Public Health

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Background The association between muscle defects and hypertension is well-established. However, the absence of pertinent and uncomplicated clinical indicators presents a challenge. Relative muscle strength (RMS) may offer a viable indicator. This study aimed to explore the association between RMS and hypertension. Methods A total of 12,720 individuals aged ≥ 45 years from the 2011 wave of the China Health and Retirement Longitudinal Study (CHARLS) were included. Grip strength was recorded and appendicular skeletal muscle mass (ASM) was estimated using a validated mathematical formula. The RMS was calculated as the ratio of grip strength to ASM. Hypertension was determined based on previous diagnosis, history of hypertension medication use, and current blood pressure. Logistic regression models were employed to investigate the relationship between RMS and hypertension. Results The prevalence of hypertension was 41.7% (5,307/12,720 patients). RMS was negatively correlated with hypertension with an OR (95% CI) of 0.68 (0.59–0.79) for males, 0.81 (0.73–0.90) for females, and 0.78 (0.72–0.85) for the entire population after adjusting for related covariates including age, education, marital history, smoking history, drinking history, diabetes, hyperlipidemia, and obesity. The trend test showed a linear association among males, females, or the entire population. Stratified analysis showed a consistent negative correlation between RMS and hypertension. Conclusions Higher RMS is an independent protective factor against hypertension and efforts to promote RMS may be beneficial for the prevention and management of hypertension.

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Associations Between Muscle Quality and Cognitive Function in Older Men: Cross-Sectional Data From the Geelong Osteoporosis Study

Cited by 13 publications

References 33 publications

Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1dw/dw) mouse

Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1dw/dw) mouse

Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia

Association between relative muscle strength and hypertension in middle-aged and older Chinese adults

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