Associations between motion activity, ketosis risk and estrus behavior in dairy cattle

Najm, Nour-Addeen; Zimmermann, Lisa; Dietrich, Oliver; Rieger, Anna; Martin, R.; Zerbe, Holm

doi:10.1016/j.prevetmed.2019.104857

Cited by 20 publications

(14 citation statements)

References 30 publications

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“…The high BHBA values, before, after, or before and after artificial insemination were reported associated with a six to 14% reduction in the pregnancy per artificial insemination compared with cows with low BHBA values [31]. Najm et al [32] also showed the activity of healthy cows exceeded the ketosis cows by an average of 52.6% in 4-70 DIM and the mean motion activity on the day of estrus was also higher in healthy cows. The activity level of the cow will also affect the effective monitoring of estrus, which may be a factor decreasing the reproductive performance, especially detecting estrus by automated surveillance systems.…”

Section: Decreasing the Reproductive Performancementioning

confidence: 94%

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Zhang

Nan

Wang

et al. 2020

Animals

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With the improvement in the intense genetic selection of dairy cows, advanced management strategies, and improved feed quality and disease control, milk production level has been greatly improved. However, the negative energy balance (NEB) is increasingly serious at the postpartum stage because the intake of nutrients cannot meet the demand of quickly improved milk production. The NEB leads to a large amount of body fat mobilization and consequently the elevated production of ketones, which causes metabolic diseases such as ketosis and fatty liver. The high milk production of dairy cows in early lactation aggravates NEB. The metabolic diseases lead to metabolic disorders, a decrease in reproductive performance, and lactation performance decline, seriously affecting the health and production of cows. Propylene glycol (PG) can alleviate NEB through gluconeogenesis and inhibit the synthesis of ketone bodies. In addition, PG improves milk yield, reproduction, and immune performance by improving plasma glucose and liver function in ketosis cows, and reduces milk fat percentage. However, a large dose of PG (above 500 g/d) has toxic and side effects in cows. The feeding method used was an oral drench. The combination of PG with some other additives can improve the effects in preventing ketosis. Overall, the present review summarizes the recent research progress in the impacts of NEB in dairy cows and the properties of PG in alleviating NEB and reducing the risk of ketosis.

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Section: Decreasing the Reproductive Performancementioning

confidence: 94%

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Zhang

Nan

Wang

et al. 2020

Animals

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“…Ketosis can reduce physical activity around the time of estrus in dairy cows and prolong the interval from calving to the first service (10,11). This may be related to the high levels of BHBA which can damage granulosa cells (GCs) and inhibit follicular development, thus leading to a disrupted estrus cycle and long-term effects on reproductive efficiency (12)(13)(14). It is well known that ovarian GCs are vital to estrogen synthesis, follicular growth, oocyte development, ovulation, and luteinization (15,16).…”

Section: Introductionmentioning

confidence: 99%

The Dynamic Transcription Profiles of Proliferating Bovine Ovarian Granulosa When Exposed to Increased Levels of β-Hydroxybutyric Acid

et al. 2022

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Ketosis is common in high-yield dairy cows. It is a condition that is characterized by the accumulation of serum β-hydroxybutyric acid (BHBA). Both subclinical ketosis and clinical ketosis can compromise the reproductive performance and cause long-lasting negative effects on reproductive efficiency by affecting the proliferation of follicular and granulosa cells. However, the regulatory mechanisms involved in the development of follicular cells and granulosa cells in cows experiencing subclinical ketosis and clinical ketosis remain largely unknown. To investigate the effect of a ketosis-triggered increase in BHBA on bovine follicular granulosa cell development, we detected a significant reduction in the proliferation of granulosa cells (P < 0.05) in the BHBA-1.2 mM and BHBA-2.4 mM groups and a significant increase in the number of granulosa cells in the G1 phase of the cell cycle (P < 0.05). RNA-seq and trend analysis were used to identify differentially expressed genes by comparing three clusters: low-concentration response to 1.2 mM BHBA, high-concentration response to 2.4 mM BHBA, and the similar trend (up or down) response following BHBA concentration increased. GO and KEGG enrichment analyses were performed separately for each cluster. Analysis showed that two novel down-regulated genes (G0S2 and S100A6), which are associated with cell proliferation and cycle progression, were enriched in the low-concentration response to 1.2 mM BHBA. Another differentially expressed gene (PARP), which plays a role in the apoptotic pathway, was enriched in the high-concentration response to 2.4 mM BHBA. We also found that CYP27B1 and CYP17A1, which are associated with Ca2+ homeostasis and estrogen synthesis, were enriched in a similar trend response. In conclusion, we describe the dynamic transcription profiles of granulosa cells under different levels of β-hydroxybutyric stress and report key regulators that may underlie the detrimental effects on the development of follicles and granulosa cells, thus representing potential therapeutic targets to improve fertility in dairy cows with subclinical ketosis or clinical ketosis.

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“…According to Poulopoulou et al [39], high correlations were confirmed for the activities feeding, ruminating, standing and lying. Significantly reduced motion activity was found in ketotic animals compared to healthy animals [12]. Promising future applications include the early detection of lameness which is associated with alterations in walking activity [40], or metabolic diseases, which can be predicted by changes in feeding and ruminating behaviours [5].…”

Section: Resultsmentioning

confidence: 99%

“…For example, retained placenta, mastitis, displaced abomasum, metritis or lameness could have influenced the walking activity behaviour of the animals [7,10,11]. In cows with SCK, the walking activity was generally lower than that of healthy cows [12]. According to our knowledge, limited research has been done to evaluate the relationship between subclinical ketosis and changes in locomotion behaviour (time spent with the head up during feeding, time spent with head down during feeding, walking activity and frequency of switching between activities) along with the average, maximal and minimal ambient temperatures.…”

Section: Introductionmentioning

confidence: 99%

Relation of Subclinical Ketosis of Dairy Cows with Locomotion Behaviour and Ambient Temperature

Antanaitis

Juozaitienė

Televičius

et al. 2020

Animals

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Rumination time, chewing time and drinking time are indicators that can be assessed in case of cow disease. In this research, two groups of cows were formed: cows with subclinical ketosis (SCK; n = 10) and healthy cows (HG; n = 10). Behaviour such as walking activity, feeding time with head position up, feeding time with head position down, change of activity and average, minimal and maximal ambient temperature of cows were recorded by the RumiWatch noseband system (RWS; RumiWatch System, Itin+Hoch GmbH, Liestal, Switzerland). The RWS comprises a noseband halter with a built-in pressure sensor and a liquid-filled pressure tube. Data from each studied cow were recorded for 420 h. According to the results of our study, it was determined that cows diagnosed with subclinical ketosis showed a tendency to change their activity more frequently. Our data indicates that minimal and maximal ambient temperatures are related with SCK.

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Associations between motion activity, ketosis risk and estrus behavior in dairy cattle

Cited by 20 publications

References 30 publications

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

The Dynamic Transcription Profiles of Proliferating Bovine Ovarian Granulosa When Exposed to Increased Levels of β-Hydroxybutyric Acid

Relation of Subclinical Ketosis of Dairy Cows with Locomotion Behaviour and Ambient Temperature

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