Associations between morningness/eveningness and psychopathology: An epidemiological survey in three in-patient psychiatric clinics

Lemoine, P.; Zawieja, Philippe; Ohayon, Maurice M.

doi:10.1016/j.jpsychires.2013.04.001

Cited by 80 publications

(56 citation statements)

References 30 publications

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“…The human biological clock determines synchronization of light-dark rhythm with physiological and mental processes (Lemoine et al 2013, Frank et al 2008, Ohayon 2007a. Chronotype (CH) is an expression of individual circadian rhythm differences, defining the preference of morning (lark) or evening (owl) activity (Pracki et al 2014).…”

Section: Objectivesmentioning

confidence: 99%

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

Dmitrzak‐Węglarz¹,

Pawlak²,

Wiłkość³

et al. 2016

Acta Neurobiologiae Experimentalis

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Genetic background and clinical picture of mood disorders (MD) are complex and may depend on many genes and their potential interactions as well as environmental factors. Therefore, clinical variations, or endophenotypes, were suggested for association studies.The aim of the study was to investigate association between the chronotype (CH) and quality of sleep characteristics with polymorphisms CLOCK, ARNTL, TIMELESS and PER3 genes in MD. We included a total sample of 111 inpatients and 126 healthy controls. To assess CH we applied Morningness-Eveningness Questionnaire (MEQ). Additionally, we defined the quality and patterns of sleep using The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). We applied Kruskal-Wallis test to determine associations. The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271), 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739), 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315), 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350), 5) sleep disturbances with the ARNTL gene (rs11600996).We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.The present study suggests a putative role of the analyzed clock genes polymorphisms in chronotype in the control group and in sleep quality disturbances in the course of MD. The results indicate that PSQI variables can be used to refine phenotype in association studies of clock genes in MD.

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Section: Objectivesmentioning

confidence: 99%

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

Dmitrzak‐Węglarz¹,

Pawlak²,

Wiłkość³

et al. 2016

Acta Neurobiologiae Experimentalis

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“…Anxiety is associated with poor sleep (Kajimura et al, 1998) and evening chronotype (Adan et al, 2012; Lemoine et al, 2013). For example, the Neuroticism component of the 5-factor theory of personality, as quantified using the NEO Personality Inventory Revised (NEO-PI-R) (Costa and McCrae, 1992), is a significant predictor of both the Pittsburgh Sleep Quality Index (PSQI) (Buysse et al, 1989) measure of poor sleep (Calkins et al, 2013) as well as of poor sleep hygiene (Duggan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Greater risk of anxiety disorders in evening types may be mediated, in part, by asynchrony of their activity patterns with normative schedules (“social jetlag”) (Wittmann et al, 2006). Correspondingly, individuals with anxiety disorders are more likely to be evening-types (Lemoine et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Emotional trait and memory associates of sleep timing and quality

Pace‐Schott

Rubin

Tracy

et al. 2015

Psychiatry Research

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Poor ability to remember the extinction of conditioned fear, elevated trait anxiety, and delayed or disrupted nocturnal sleep are reported in anxiety disorders. The current study examines the interrelationship of these factors in healthy young-adult males. Skin- conductance response was conditioned to two differently colored lamps. One color but not the other was then extinguished. After varying delays, both colors were presented to determine extinction recall and generalization. Questionnaires measured sleep quality, morningness - eveningness, neuroticism and trait anxiety. A subset produced a mean 7.0 nights of actigraphy and sleep diaries. Median split of mean sleep midpoint defined early-and late-”sleep timers”. Extinction was more rapidly learned in the morning than evening only in early-timers, who also better generalized extinction recall. Extinction recall was greater with higher sleep efficiency. Sleep efficiency and morningness were negatively associated with neuroticism and anxiety. However, neuroticism and anxiety did not predict extinction learning, recall or generalization. Therefore, neuroticism/anxiety and deficient fear extinction, although both associated with poor quality and late timing of sleep, are not directly associated with each other. Elevated trait anxiety, in addition to predisposing directly to anxiety disorders, may thus also indirectly promote such disorders by impairing sleep and, consequently, extinction memory.

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“…Investigators have also noted that 20–25% of individuals aged 12–24 experience one or more common psychiatric disorders (CPDs) per year (Patel et al, 2007). These disorders include: major depressive disorder, anxiety, bipolar depression, psychosis and addiction (Lemoine et al, 2013). Furthermore, CPDs constituted 60–70 % of the Disability Adjusted Life Years (DALYs) in individuals aged 15–24 years old (Public Health Group, 2005).…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythm characteristics, poor sleep quality, daytime sleepiness and common psychiatric disorders among Thai college students

Haregu¹,

Gelaye²,

Pensuksan

et al. 2014

Asia-Pacific Psychiatry

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Objective To investigate the relationship between common psychiatric disorders (CPDs) and sleep characteristics (evening chronotype, poor sleep quality and daytime sleepiness) among Thai college students. Methods A cross-sectional study was conducted among 2,970 undergraduate students in Thailand. Students were asked to complete a self-administered questionnaire that collected information about lifestyle and demographic characteristics. The Horne and Ostberg Morningess-Eveningeness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS), were used to evaluate circadian preference, sleep quality and daytime sleepiness respectively. The General Health Questionnaire-12 (GHQ-12) was used to evaluate presence of CPDs. Logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) of CPDs in relation to the covariates of interest. Results A total of 337 students were classified as having CPDs (11.2%; 95% CI 10.1–12.3%). Evening chronotype (OR=3.35; 95% CI 2.09–5.37), poor sleep quality (OR=4.89; 95% CI 3.66–6.54) and daytime sleepiness (OR=1.95; 95% CI 1.54–2.47) were statistically significantly associated with CPDs. Conclusions Our study demonstrated that CPDs are common among Thai college students. Further, evening chronotype, poor sleep quality and excessive daytime sleepiness were strongly associated with increased risk of CPDs. These findings highlight the importance of educating students and school administrators about the importance of sleep and its impact on mental health.

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Associations between morningness/eveningness and psychopathology: An epidemiological survey in three in-patient psychiatric clinics

Cited by 80 publications

References 30 publications

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

Emotional trait and memory associates of sleep timing and quality

Circadian rhythm characteristics, poor sleep quality, daytime sleepiness and common psychiatric disorders among Thai college students

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