Associations between miR-146a rs2910164 polymorphisms and risk of ischemic cardio-cerebrovascular diseases

Zhao, Dongdong; Li, Yuerong; Yu, Xiaoqing; Zhu, Yuezhi; Ma, Ben

doi:10.1097/md.0000000000017106

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…It has been reported that miR-146a levels were shown to be greater in AMI patients of the Chinese population, and the GG phenotype of MIR146A rs2910164 was linked with a higher risk of AMI than the CC phenotype [ 49 ]. In contrast to our findings, a previous study found that the MIR146A rs2910164 variant is associated with a reduced risk of CHD in the Asian population [ 50 ]. A recent study by Mehrjardi et al revealed no statistically significant correlation between the MIR146A gene polymorphism (rs2910164) and CAD within the Iranian population [ 51 ].…”

Section: Discussioncontrasting

confidence: 99%

Genetic variants rs2910164, rs4636297 and rs895819 may contribute to the onset of acute myocardial infarction in Pakistani population

Ali,

Haq,

Hussain

et al. 2024

PLoS ONE

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The most serious type of coronary artery disease (CAD), acute myocardial infarction (AMI), is a major global cause of death. The development of AMI is accompanied by several risk factors. AMI may be caused by variations in the microRNA (miRNA) genes, which have a negative impact on miRNA-mediated regulation of gene expression. The target mRNAs are dysregulated because of these genetic changes in the miRNA genes, which interfere with the vital biological processes that result in AMI. Using allele-specific PCR, the aim of the study is to examine the association of the variants (rs2910164, rs4636297, and rs895819) in MIR146A, MIR126, and MIR27A with AMI susceptibility. A difference in genotype distribution among the patients and control for variation rs2910164 was identified by co-dominant [χ2 = 68.34,2; P value<0.0001], dominant (G/G vs G/C + C/C) [OR = 4.167 (2.860–6.049); P value<0.0001], recessive (C/C vs G/C + G/G) [OR = 0.2584 (0.1798–0.3731); P value<0.0001], and additive models [OR = 3.847 (2.985–4.959); P value<0.0001]. Whereas the association of rs4636297 was investigated by co-dominant [χ2 = 6.882,2; P value = 0.0320], dominant (G/G vs G/A + A/A) [OR = 0.6914 (0.4849–0.9948); P value = 0.0489], recessive (A/A vs A/G + G/G) [OR = 2.434 (0.9849–5.616830); P value = 0.0595], and additive models [OR = 0.7716 (0.6000–0.9918); P value = 0.0433]. Similarly, association of rs895819 was determined by co-dominant [χ2 = 5.277, 2; P value = 0.0715], dominant (G/G vs G/A + A/A) [OR = 1.654(0.9819–2.801); P value = 0.06440], recessive (A/A vs A/G + G/G) [OR = 0.7227 (0.5132–1.022); P value = 0.0748], and additive models [OR = 1.3337 (1.041–1.719); P value = 0.0233]. The results of this study found a significant association of rs2910164 and rs4636297 with AMI and are considered as the risk factor for AMI in the Pakistani population. We observed no significant association of the variant MIR27A (rs895819) with AMI incidence.

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Section: Discussioncontrasting

confidence: 99%

Genetic variants rs2910164, rs4636297 and rs895819 may contribute to the onset of acute myocardial infarction in Pakistani population

Ali,

Haq,

Hussain

et al. 2024

PLoS ONE

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“…Cerebrovascular disease refers to acute and chronic cerebrovascular diseases caused by various reasons. As a common and frequently occurring disease in the nervous system, cerebrovascular disease is currently one of the three major diseases leading to human death, second only to cardiovascular disease and cancer ( 1 , 2 ). Ischemic cerebrovascular diseases mainly include transient ischemic attack and cerebral infarction, accounting for about 80% of all strokes, and the proportion is higher in elderly patients.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Application Effects of Different Hemostasis Methods After Ischemic Cerebrovascular Intervention

Zhou

2022

Front. Surg.

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ObjectiveTo explore the effects of two different hemostasis methods, namely, arterial compression devices and vascular closure devices, in the ischemic cerebrovascular intervention to provide a theoretical basis for clinical selection of hemostasis methods.MethodsA total of 302 patients who underwent ischemic cerebrovascular intervention in our hospital from January 2016 to December 2020 were selected as the research subjects and randomly divided into the control group (n = 151) and the observation group (n = 151). The patients in both groups underwent cerebrovascular intervention. The patients in the control group were treated with an artery compressor for hemostasis after the operation, while those in the observation group were treated with vascular closure devices for hemostasis. The hemostatic indexes and vascular parameters at the puncture site before and after the operation were compared between the two groups. The comfort level of the patients was assessed at 6, 12, and 24 h after the operation with the Kolcaba Comfort Scale score, and the postoperative complications were recorded.ResultsThere was no significant difference in the success rate of hemostasis between the two groups (p > 0.05). The hemostatic time and immobilization time of (2.69 ± 0.62) min and (4.82 ± 0.93) h in the observation group were lower than those in the control group with (16.24 ± 3.58) min and (7.94 ± 1.86) h (p < 0.05). The differences in the minimum inner diameter of the puncture site and its nearby vessels and the peak velocity of blood flow between the two groups before and after the operation were not statistically significant within or between groups (p > 0.05). The scores of the Kolcaba comfort scale in the observation group (80.16 ± 8.49) and (93.65 ± 9.26) at 6 and 12 h, respectively, after the operation, were higher than those in the control groups (72.08 ± 7.54) and (85.49 ± 8.63) (p < 0.05). The 24 h postoperative Kolcaba comfort scale score was (97.54 ± 9.86) in the observation group and (96.82 ± 9.64) in the control group, and the difference was not statistically significant (p > 0.05). In the control group, there were 7 cases of dysuria, 12 cases of low back pain, 14 cases of sleep disorder, 20 cases of mental stress, and 5 cases of wound bleeding, and the total incidence of complications was 38.41% (58/151). In the observation group, there were 4 cases of dysuria, 8 cases of low back pain, 10 cases of sleep disorder, 14 cases of mental stress, and 3 cases of wound bleeding, and the total incidence of complications was 25.83% (39/151). The total incidence of complications in the observation group was lower than that in the control group (p < 0.05).ConclusionFor patients with ischemic cerebrovascular disease undergoing femoral artery puncture intervention, the use of vascular closure devices can stop the bleeding quickly, which can significantly shorten the bleeding time, and the postoperative braking time of patients is short, with high comfort and fewer complications.

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“…[ 10 , 11 ] Studies show that miR-146a is involved in the process of CHD. [ 12 , 13 ] For instance, a previous study showed that miR-146a expression was higher in the coronary artery disease (CAD) group. [ 14 ] Furthermore, treatments with angiotensin II receptor blockers and statin could suppress the level of miR-146a and toll-like receptor 4 signal pathway, which might be the molecular mechanism concerning the anti-atherosclerosis of angiotensin II receptor blockers and statin in CAD patients.…”

Section: Introductionmentioning

confidence: 99%

Association between microRNA-146a rs2910164 polymorphism and coronary heart disease: An updated meta-analysis

Bao¹,

Li²,

Wang³

et al. 2022

Medicine

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Background: Coronary heart disease (CHD) is one of the manifestations of atherosclerosis with a high morbidity rate. MicroRNA (miRNA)-146a rs2910164, a single nucleotide polymorphism, is associated with the progression of CHD risk. However, the results are controversial and uncertain. Therefore, an updated meta-analysis was conducted to evaluate the association between rs2910164 and CHD susceptibility.Methods: PubMed, Cochrane Library, EMBASE, Web of Science, China's National Knowledge Infrastructure, VIP, and Wan fang were searched for the eligible articles until April 30, 2022. The odds ratios (ORs) with 95% confidence interval (CIs) were calculated to assess the correlation. Bonferroni correction was utilized between multiple comparisons. Trial sequential analysis was performed to measure the required information size and assess the reliability of the meta-analysis results.Results: A total of 18 eligible studies, including 6859 cases and 8469 controls, were analyzed in our meta-analysis. After Bonferroni correction, we found that the G allele at rs2910164 was associated with significantly decreased CHD risk in the allelic model (OR = 0.86), homozygous model (OR = 0.79), and heterozygous model (OR = 0.89) in total population. In the subgroup analysis, the subjects containing the G allele and GG genotype were associated with a lower risk of CHD in the Chinese population, not the GG + CG and CG genotype. In addition, under the allelic, homozygous, heterozygous, and dominant models, miR-146a rs2910164 was at lower CHD risk in the large size population except in the recessive model. Conclusion:These results show that miR-146a rs2910164 might be associated with lower CHD susceptibility.Abbreviations: CAD = coronary artery disease, CHD = coronary heart disease, CI = confidence interval, HWE = Hardy-Weinberg equilibrium, IRAK-1 = interleukin-1 receptor-associated kinase 1, miRNA = microRNA, NF-κB = nuclear factor Kappa B, RIS = required information size, SNP = single nucleotide polymorphism, TRAF-6 = tumor necrosis factor receptor-associated factor 6, TSA = trial sequential analysis.

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Associations between miR-146a rs2910164 polymorphisms and risk of ischemic cardio-cerebrovascular diseases

Cited by 7 publications

References 38 publications

Genetic variants rs2910164, rs4636297 and rs895819 may contribute to the onset of acute myocardial infarction in Pakistani population

Genetic variants rs2910164, rs4636297 and rs895819 may contribute to the onset of acute myocardial infarction in Pakistani population

Comparison of Application Effects of Different Hemostasis Methods After Ischemic Cerebrovascular Intervention

Association between microRNA-146a rs2910164 polymorphism and coronary heart disease: An updated meta-analysis

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