Associations between maternal serum HDL-c concentrations during pregnancy and neonatal birth weight: a population-based cohort study

Wang, Hongliang; Dang, Qinyu; Zhu, Haiyan; Liang, Ning; Le, Zhiyin; Huang, Dongxu; Xiao, Rong; Yu, Huanling

doi:10.1186/s12944-020-01264-0

Cited by 18 publications

(12 citation statements)

References 39 publications

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“…While previous studies did not propose any association between maternal LDL-c levels and abnormal birth weight ( 44 – 46 ), we observed elevated LDL-c in the first trimester increased odds of LGA, but not macrosomia. In the current study, no detectable association between maternal HDL-c and birth weight or adverse birth outcomes was found as previously suggested in several studies ( 47 , 48 ) ( 36 , 49 ). The inconsistent results in different studies could be explained by different gestational weeks when the blood was collected and the variances in the study population.…”

Section: Discussionsupporting

confidence: 85%

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Zhu

Zhang

et al. 2022

Front. Endocrinol.

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IntroductionElevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead to abnormal birth weight.ObjectiveIn this study, we aimed to explore the association between maternal lipid profiles during early pregnancy and birth weight with stratified pre-pregnancy body mass index (BMI).MethodsThis retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women with singleton live birth between January 2018 and October 2020. All of the enrolled women had fasting lipid concentrations measured in early pregnancy. The primary outcomes were birth weight and risks of adverse birth outcomes, including macrosomia, large for gestational age (LGA), low birth weight (LBW), and small for gestational age (SGA).ResultsHigher maternal concentrations of total cholesterol (TC), triglyceride (TG), and low-density cholesterol (LDL-c) in early pregnancy were associated with increased birth weight. Ln transformed TG and levels exhibited a positive association with LGA and macrosomia (OR = 1.33, 95% CI: 1.25, 1.42 and OR = 1.37, 95% CI: 1.24, 1.52) and showed a negative relationship with SGA (OR = 0.73, 95% CI: 0.62, 0.85). High TG (>75th percentile, 1.67 mmol/L) group also showed higher risks of LGA and macrosomia (OR = 1.21, 95% CI: 1.15, 1.28 and OR = 1.20, 95% CI: 1.10, 1.31) and decreased prevalence of SGA (OR = 0.71, 95% CI: 0.61, 0.83). Moreover, significant combined effects of pre-pregnancy BMI and lipid profiles on LGA and macrosomia were identified.ConclusionsElevated maternal lipid profiles in early pregnancy are associated with higher birth weight and increased risks of LGA and macrosomia. We propose that serum lipid profiles in early pregnancy and pre-pregnancy BMI could serve as screening indexes for high-risk women.

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Section: Discussionsupporting

confidence: 85%

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Zhu

Zhang

et al. 2022

Front. Endocrinol.

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“…Jin et al 25 found that the high third-trimester TG concentration was associated with a decreased risk for SGA and an increased risk for LGA. Di Cianni et al 28 and a recent Dutch study 14 also found similar results in different gestational ages. In recent years, studies have found that elevated TG levels lead to vascular endothelial dysfunction and enhanced lipid peroxidation which resulted in damage to vascular endothelial cells.…”

Section: Discussionsupporting

confidence: 55%

“…Misra et al 27 also reported a negative association between HDL-C and birth weight at all time points starting at 10 weeks’ gestation in overweight or obese women. One recent study 28 showed that maternal serum HDL-C concentrations were inversely associated with birthweight at 24th and 36th gestational weeks and the high concentrations of HDL-C at the 36th gestational week increased the risk of SGA. There was a tendency that pregnant women with higher HDL-C concentrations throughout pregnancy gave birth to infants with lower birth weight.…”

Section: Discussionmentioning

confidence: 99%

Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants

Chen

et al. 2020

Sci Rep

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Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an adverse pregnancy outcome, small-for-gestational-age has been extensively studied in Western countries. However, similar studies have rarely been conducted in Asian countries. Data were derived from 5695 pairs of non-diabetic mothers and neonates between 1 Jan 2014 and 31 Dec 2014. 5.6% neonates in our study were SGA. Serum samples were collected during second and third trimesters for evaluation on fasting lipids levels. The present study intended to explore the associations between maternal lipid profile and small-for-gestational-age neonates. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and adjusted via logistic regression analysis. After adjustments for confounders, third-trimester total cholesterol levels were associated with a decreased risk for small-for-gestational-age (aOR = 0.622, 95% CI 0.458–0.848, P = 0.002), and third-trimester high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were associated with an increased risk for small-for-gestational-age (aOR = 1.955, 95% CI 1.465–2.578, P < 0.001; aOR = 1.403, 95% CI 1.014–1.944, P = 0.041).In the highest gestational weight gain strata, especially the third-trimester, the effect of high-density lipoprotein cholesterol levels on the risk for small-for-gestational-age is larger. High high-density lipoprotein cholesterol level during third trimester could be considered as indicators of a high-risk of small-for-gestational-age, regardless of gestational weight gain.

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“…However, a systematic review found that the risk of PTB was not affected by HDL-c [21]. There was also a tendency for maternal high levels of HDL-c to be associated with an increased risk of SGA [22][23][24]. Therefore, controversies still exist regarding the correlation between maternal HDL-c and PTB and SGA.…”

Section: Introductionmentioning

confidence: 99%

Maternal HDL-c levels are associated with preterm birth and small for gestational age: A prospective study in China

Chen

Feng

Yang

et al. 2022

Preprint

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Background: Evidence suggests that maternal HDL-c levels are associated with preterm birth (PTB) and small for gestational age (SGA). However, existing evidence remains controversial. We aimed to explore the associations of maternal HDL-c levels with PTB and SGA in China.Method: A prospective study that included 1068 pregnant women was conducted in 2017. The concentrations of high-density lipoprotein cholesterol (HDL-c) were analyzed in early, middle, and late pregnancy as continuous variables and categorical variables (by percentile groups). Data on gestational age, as well as the weight and length of the neonates were recorded after delivery. Multivariable logistic regression models were used to estimate the associations between maternal HDL-c levels and PTB and SGA. Result:PTB and SGA occurred in 3.0% and 8.1% of births. Mean maternal HDL-c levels in early pregnancy was equal to that in middle pregnancy (1.67 vs. 1.66 mmol/L, p = 0.309), but decreased slightly from middle pregnancy to late pregnancy (1.66 vs. 1.52mmol/L, p < 0.001). In middle pregnancy, every unit elevation of HDL-c was positively associated with SGA (OR = 2.57, 95 % CI: 1.23-5.35). In late pregnancy, every unit elevation of HDL-c reduced the risk of PTB (OR = 0.12, 95 % CI: 0.03-0.58), but increased the risk of SGA (OR = 2.59, 95 % CI: 1.22-5.47). In early pregnancy, low (<25th percentile) HDL-c was positively associated with PTB (OR = 2.56, 95 % CI: 1.11-5.09), and high (>75th percentile) HDL-c was positively associated with SGA (OR = 2.92, 95 % CI: 1.69-5.04), compared with referent (25th-75th percentile) HDL-c.Conclusion:Maternal high levels of HDL-c could reduce the risk of PTB but increase the risk of SGA. There may exist appropriate reference range for maternal HDL-c in early pregnancy. Maternal HDL-c levels should be monitored regularly during pregnancy to decrease adverse perinatal outcomes.

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Associations between maternal serum HDL-c concentrations during pregnancy and neonatal birth weight: a population-based cohort study

Cited by 18 publications

References 39 publications

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants

Maternal HDL-c levels are associated with preterm birth and small for gestational age: A prospective study in China

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