Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study

Abstract

Background: Maternal immune system regulation is critical for maintenance of a healthy pregnancy and fetal development. Exposure to phenols and parabens is widespread, and may be linked to systemic inflammation and alteration of circulating immunological biomarkers. Objective: We sought to characterize associations between repeated measures of individual urinary phenols, parabens and plasma inflammatory markers across pregnancy. Methods: In the LIFECODES prospective birth cohort, we conducted a nested preterm birth case-control study, including 130 cases and 352 controls. In urine samples collected from each participant at up to four study visits during pregnancy, we measured concentrations of six phenols and four parabens, as well as five plasma inflammatory markers. We used multivariable linear mixed models to analyze repeated measures of exposures on inflammatory markers. We created and applied inverse probability weights to account for the sampling approach. Results: We observed bidirectional associations between select phenols and parabens and inflammatory markers. An interquartile range increase in triclosan (55.2 ng/mL) was associated *

The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico

“…Therefore, an endocrine-mediated mechanism could potentially be leading to the increase in gestational age. Alternatively, BP-3 was associated with lower concentrations of proinflammatory markers in a large pregnancy cohort (Aung et al, 2019) which may also impact duration of pregnancy.…”

Application of an analytical framework for multivariate mediation analysis of environmental data

“…All exposure analytes were measured in urine samples by NSF International in Ann Arbor, MI. Quantification of individual toxicants and analytes followed protocols developed by the Centers for Disease Control and Prevention [44][45][46][47] . We used high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) to quantify a total of nine phthalate metabolites.…”

Environmental Contaminants Exposure and Preterm Birth: A Systematic Review

“…The role of these toxic compounds in adverse pregnancy outcome is controversial, as they can have a double effect on the immune system, i.e., a proinflammatory or an anti-inflammatory effect. Aung et al, in 2018, reported that urinary levels of TCS, 2,5-dichlorophenol (2-5-DCP), and MPB in mothers’ urine is associated with an increase of IL-6, IL-12, and TNF alpha, probably through the stimulation of the estrogen receptor, while higher urinary concentrations of EPB and BP3 are associated with lower concentrations of proinflammatory cytokines [68].…”