Associations Between Maternal PBDE Serum Concentrations and Child Neurodevelopment in the Chamacos Cohort

Eskenazi, Brenda; Marks, Amy R.; Chevrier, Jonathan; Harley, Kim G.; Bradman, A; Sjödin, Andreas

doi:10.1097/01.ede.0000362995.59556.bf

Cited by 2 publications

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“…Because of their persistence in the environment and their potentially harmful effects (e.g. neurobehavioral outcomes) (Darnerud et al, 2001;Palm et al, 2002;Eskenazi et al, 2009;Roze et al, 2009;Herbstman et al, 2010;Gascon et al, 2011;Shy et al, 2011;Gascon et al, 2012), industry voluntarily ended production of penta-and octa-BDE commercial mixtures in 2005 and deca-BDE production in 2013 (van der Veen and de Boer, 2012;EPA, 2014;Howard, 2014). This phase-out prompted an increase in the use of other flame retardants to meet flammability standards, including organophosphate esters (OPEs) (also referred to as PFRs (phosphorous flame retardants) and OPFRs (organophosphate flame retardants)) to replace PBDEs in consumer products (Dodson et al, 2012;Stapleton et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Differential exposure to organophosphate flame retardants in mother-child pairs

et al. 2019

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Background: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust.Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.Objectives: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. We additionally assessed the ability of silicone wristbands (measuring ambient exposure) to predict urinary metabolite concentrations. Methods: We selected 32 mother and child dyads from an existing cohort. Participants provided baseline urine samples and wore wristbands for one week. After the first week, they returned their wristbands and provided a second urine sample. During the second week, participants wore a second wristband that they returned at the end of week two with a third and final urine sample. Results:We found significantly higher levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) (p < 0.001) and lower levels of bis(1-chloro-2-isopropyl) I-hydroxy-2-propyl phosphate (BCIPHIPP) (p < 0.001) in children's urine samples compared to mothers' samples at baseline. We found that triphenylphosphate (TPHP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP), and tris(1-chloro-2-propyl) phosphate (TCIPP) measured in wristbands predicted their respective metabolite levels in urine.

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Section: Introductionmentioning

confidence: 99%

Differential exposure to organophosphate flame retardants in mother-child pairs

et al. 2019

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“…Polybrominated diphenyl ethers (PBDEs) were originally the most highly used chemicals for reducing flammability in furniture because of their low cost, efficiency, and availability [4, 5]. Growing concerns over the health impacts of exposure (i.e., neurobehavioral effects) [6–11] led to the voluntary phase-out of industrial production and application of penta- and octa-BDE mixtures by 2005. Phase-out of deca-BDE was meant to be completed by 2013, with the largest producers and importers of deca-BDE in the US committing to end its production, importation, and sale for all uses, but its status is still uncertain [12–14].…”

Section: Introductionmentioning

confidence: 99%