Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study

Yeates, Alison J.; McSorley, Emeir M.; Mulhern, Maria S.; Spence, Toni; Crowe, William E.; Grzesik, Katherine; Thurston, Sally W.; Watson, Gene E.; Myers, Gary J.; Davidson, Philip W.; Shamlaye, Conrad; Wijngaarden, Edwin van; Strain, James J.

doi:10.1016/j.jri.2019.102623

Cited by 15 publications

(13 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have reported, contrary to our finding, that maternal serum CRP and MCP-1 concentrations are negatively correlated to birthweight. Thus, CRP at 28 weeks' gestation in healthy pregnant women, as well as maternal MCP-1 at third trimester (32-34 weeks), were associated with SGA births [19,20]. The discrepancy between our finding and others might be related to gestational age at sampling.…”

Section: Discussioncontrasting

confidence: 86%

See 1 more Smart Citation

Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

et al. 2022

View full text Add to dashboard Cite

Objectives: Maternal obesity increases the risk of gestational diabetes mellitus (GDM) and is positively correlated with neonatal obesity increasing the risk of adiposity in both young and adult offspring. Maternal secreted factors from adipose tissue such as adipokines and inflammatory cytokines may regulate fetal growth. This study investigated associations between maternal adipokines and inflammatory markers at late gestation, and neonatal anthropometric characteristics in mothers with and without GDM. Material and methods:The study included 65 women with GDM and 65 pregnant women with normal glucose tolerance evaluated at the time of term elective Caesarean section.Adiponectin, leptin, resistin, adipsin, neutrophil gelatinase-associated lipocalin (NGAL), nerve growth factor (NGF), monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in maternal serum by the multiplex immunoassay using Magpix technology. C-reactive protein (CRP) was measured with a particle-enhanced turbidimetric immunoassay and neonatal anthropometric variables were assessed. The association of birthweight with individual biomarkers was analyzed using multivariate logistic regression adjusted for maternal factors.Results: Adiponectin, leptin, resistin, adipsin, NGAL and NGF were not significantly associated with higher birthweight. The maternal factors in association with higher birthweight observed in GDM were CRP, MCP-1 and TNF-alpha levels. Regression analysis showed that TNF-alpha was an independent risk factor for higher birthweight (p = 0.046).Conclusions: These results suggest an involvement of maternal inflammatory markers at late gestation and fetal growth in mothers with GDM, and that TNF-alpha could play a major role.

show abstract

Section: Discussioncontrasting

confidence: 86%

“…MCP-1 increases during normal pregnancy and even more during labor, suggesting that MCP-1 modulates the immune system as pregnancy advances. Several studies have reported that maternal serum CRP and MCP-1 concentrations are negatively correlated to birthweight [19,20].…”

Section: Introductionmentioning

confidence: 99%

Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…Understanding the association of maternal inflammatory responses during pregnancy with birth and infant outcomes could potentially help identify interventions (eg, antiinflammatory agents) that could reduce adverse birth outcomes and infant growth deficits. 6 To address these gaps in research, we measured inflammatory markers, informing on aspects of general inflammation and acute phase response, inflammasome activation, gut integrity, monocyte activation, and T H responses in pregnant women from a cohort study in India. We then assessed the association of these markers with adverse birth outcomes (PTB and LBW) and infant growth (length-for-age z score [LAZ], weight-for-age z score [WAZ], and weight-for-length z score [WLZ]).…”

Section: Introductionmentioning

confidence: 99%

Association of Maternal Inflammation During Pregnancy With Birth Outcomes and Infant Growth Among Women With or Without HIV in India

et al. 2021

View full text Add to dashboard Cite

Key Points Question Is elevated inflammation in pregnant women with or without HIV associated with adverse birth outcomes and infant growth deficits? Findings In this cohort study of pregnant women in Pune, India, higher levels during pregnancy of interleukin 17A were associated with increased odds of both preterm birth and low birth weight. Higher levels of interleukin 1β were associated with increased preterm birth and infant growth deficits. Meaning This study suggests that elevated inflammation during pregnancy is associated with adverse birth outcomes and infant growth deficits, and future studies should test whether modulating specific inflammatory pathways could reduce adverse birth outcomes and growth deficits.

show abstract

“…The highest levels of hsCRP are found in the 3 rd trimester of gestation in severe pre-eclampsia pregnancies compared to control and mild pre-eclampsia 8 . Moreover, negative results for hemolysis, HELLP syndrome (Hemolysis, High Liver Enzymes, Low Platelet) and intrauterine growth inhibition were higher in the group with high hsCRP levels [9][10] . Preeclampsia is a well-known risk factor for poor fetal growth and prematurity 11 .…”

Section: Introductionmentioning

confidence: 95%

Association of CRP Levels in 3rd Trimester with Fetal Birth Weight in Normotensive and Preeclamptic Pregnant Females

2022

PJMHS

View full text Add to dashboard Cite

Aim: To assess the level of C-reactive protein, which is an inflammatory marker, in pregnant women with pre-eclampsia and with normal blood pressure, and to assess its relationship with fetal weight at birth. Study design: An analytical and Cross-sectional study. Place and duration of study: In the Obstetrics and Gynecology department of Chandka Medical Hospital, Larkana and Murshid Hospital, Karachi for nine months duration from January to September 2021. Methodology: A total 70 cases of pre-eclampsia and 70 pregnant women with normal blood pressure participated, all in the 3rd trimester of gestation. All females were in the 20-40 years of age group and had a BMI ranging from 18 to 25. Highly sensitive levels of C-reactive protein (hsCRP) were evaluated using the Enzyme Link immunosorbent assay. Statistical analysis was performed with SPSS program 20.0. The values were taken as significant at the significance level of 0.05. Results: C-reactive protein levels were significantly advanced in the pre-eclampsia group with a mean value of 8.4 (0.4 to 24.2) compared to 5.1 (0.21 to 10.1) mg / L in women with normal blood pressure (p-value <0.001). Spearman's correlation coefficient between birth weight and CRP was -0.405 in the pre-eclampsia group (p = 0.001) and 0.118 in the normal blood pressure group. In the group with pre-eclampsia, the birth weights of children were also significantly lower. High CRP levels in the preeclampsia group were negatively correlated with fetal birth weight. Conclusions: High levels of C-reactive protein in pregnant women with pre-eclampsia are part of the excessive systemic maternal inflammatory response and are associated with low fetal weight. Keywords: Pre-eclampsia. C-reactive protein. Pregnancy. Third trimester

show abstract

Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study

Cited by 15 publications

References 37 publications

Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus

Association of Maternal Inflammation During Pregnancy With Birth Outcomes and Infant Growth Among Women With or Without HIV in India

Association of CRP Levels in 3rd Trimester with Fetal Birth Weight in Normotensive and Preeclamptic Pregnant Females

Contact Info

Product

Resources

About