Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Li, Bo; Zhao, Xiulan; Dai, Sheng; Cheng, Wen

doi:10.7314/apjcp.2014.15.8.3555

Cited by 18 publications

(8 citation statements)

References 22 publications

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“…We also found that TNBC were more likely to be associated with posterior acoustic enhancement (53.3%) than ER (+) cancer (33.8%) and HER2 (+) cancer (19.0%). It is well-known that high grade, highly cellular circumscribed carcinomas tends to have enhanced through-transmission (Kim et al, 2013;Bo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes

Yang

Liu²,

Liú³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Triple-negative breast cancer (TNBC) is known to be associated with aggressive biologic features and a poor clinical outcome. Therefore, early detection of TNBC without missed diagnosis is a requirement to improve prognosis. Preoperative ultrasound features of TNBC may potentially assist in early diagnosis as characteristics of disease. Purpose: To retrospectively evaluate the sonographic features of TNBC compared to ER (+) cancers which include HER(-) and HER2 (+), and HER2 (+) cancers which are ER (-). Materials and Methods: From June 2012 through June 2014, sonographic features of 321 surgically confirmed ER (+) cancers (n=214), HER2 (+) cancers (n=66), and TNBC (n=41) were retrospectively reviewed by two ultrasound specialists in consensus. The preoperative ultrasound and clinicopathological features were compared between the three subtypes. In addition, all cases were analyzed using morphologic criteria of the ACR BI-RADS lexicon. Results: Ultrasonographically, TNBC presented as microlobulated nodules without microcalcification (p=0.034). A lower incidence of ductal carcinoma in situ (p<0.001), invasive tumor size that is>2 cm (p=0.011) and BI-RADS category 4 (p<0.001) were significantly associated with TNBC. With regard to morphologic features of 41 TNBC cases, ultrasonographically were most likely to be masses with irregular (70.7%) microlobulated shape (48.8%), be circumscribed (17.1%) or have indistinct margins (17.1%) and parallel orientation (68.9%). Especially TNBC microlobulated mass margins were more more frequent than with ER (+) (2.0%) and HER2 (+) (4.8%) cancers. Conclusions: TNBC have specific characteristic in sonograms. Ultrasonography may be useful to avoid missed diagnosis and false-negative cases of TNBC.

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Section: Discussionmentioning

confidence: 99%

Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes

Yang

Liu²,

Liú³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Some studies also have discussed the features of triple-negative breast cancers (negativity of ER, PR, and HER2) (Dogan et al, 2010;Ko et al, 2010;Dogan et al, 2012;Krizmanich et al, 2012;Wojcinski et al, 2012;Li et al, 2014). However, correlations between ER, PR, HER2 and ultrasound findings in previous studies were varied and none had calculated the logistic regression model for reliable identification of molecular status (Kim et al, 2008;Wang et al, 2008;Au et al, 2009;Dogan et al, 2010;Ko et al, 2010a;2010b;Dogan et al, 2012;Krizmanich et al, 2012;Wojcinski et al, 2012;Irshad et al, 2013).…”

Section: Ultrasound Utility For Predicting Biological Behavior Of Invmentioning

confidence: 99%

Ultrasound Utility for Predicting Biological Behavior of Invasive Ductal Breast Cancers

Zhang

Liu²,

Jiang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (19), 8057-8062 IntroductionDetermination of the molecular status of invasive breast cancer is useful as a prognostic and predictive factor, and it has become standard practice in the management of breast cancer because estrogen receptor (ER) and human epidermal growth factor receptor2 (HER2) positivity predict response to endocrine therapy or targeted therapy with monoclonal antibodies directed against HER2 (Bauer et al., 2007;Doreen et al., 2011). If it is possible to predict molecular status on the basis of imaging characteristics, it could assist in both pretreatment planning and prognosis, as well as add to our understanding of the biologic behavior of this disease.Breast ultrasound has gained widespread acceptance as an adjunct to mammography in diagnosis of evaluating clinical or radiological suspected abnormalities (Gordon et al., 1995;Rizzatto et al., 2001). Stavros et al. reported that it has high sensitivity (98.4%) and negative predictive (99.5%) value for diagnosing breast cancers (Stavros et al., 1995). Ultrasound (US), with its merits of safety and low cost, is becoming a preferred method for both physicians and patients. Hence, more attention is needed toward US imaging to determine whether certain type of tumor biologic factors can be predicted from imaging appearances.A few studies have looked into correlation between

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“…Most alarmingly and unlike in US and Europe, TNBC is highly prevalent in Indian women at premenopausal stage (<35 year) when they are in the prime time of their reproductive life. Although mammography, ultrasound and Fine Needle Aspiration Cytology (FNAC) are the current standard diagnostic tools and various other diagnostic and prognostic biomarkers have been reported, there has been not much reduction in the incidence and mortality of triple-negative breast cancer [ 7 ]. This is because TNBCs lack both diagnostic as well as therapeutic targets which is a major unmet public health need.…”

Section: Introductionmentioning

confidence: 99%

Identification of Specific miRNA Signature in Paired Sera and Tissue Samples of Indian Women with Triple Negative Breast Cancer

et al. 2016

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Of several subtypes of breast cancer, triple negative breast cancer (TNBC) is a highly aggressive tumor that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor receptor 2 and shows a worst prognosis. The small noncoding RNAs (miRNAs) considered as master regulator of gene expression play a key role in cancer initiation, progression and drug resistance and have emerged as attractive molecular biomarkers for diagnosis, prognosis and treatment targets in cancer. We have done expression profiling of selected miRNAs in paired serum and tissue samples of TNBC patients and corresponding cell lines and compared with that of other subtypes, in order to identify novel serum miRNA biomarkers for early detection and progression of TNBC. A total of 85 paired tumor tissues and sera with an equal number of adjacent normal tissue margins and normal sera from age matched healthy women including tissue and sera samples from 15 benign fibroadenomas were employed for the study. We report for the first time an extremely high prevalence (73.9%) of TNBC in premenopausal women below 35 years of age and a significant altered expression of a panel of three specific oncogenic miRNAs- miR-21, miR-221, miR-210, and three tumor suppressor miRNAs- miR-195, miR-145 and Let-7a in both tissues and corresponding sera of TNBC patients when compared with triple positive breast cancer (TPBC) patients. While miR-21, miR-221 and miR-210 showed significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status. Interestingly, despite being a known tumor suppressor, Let-7a showed a significant overexpression in TNBCs. It is suggested that this panel of six miRNA signature may serve as a minimally invasive biomarker for an early detection of TNBC patients.

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Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Cited by 18 publications

References 22 publications

Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes

Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes

Ultrasound Utility for Predicting Biological Behavior of Invasive Ductal Breast Cancers

Identification of Specific miRNA Signature in Paired Sera and Tissue Samples of Indian Women with Triple Negative Breast Cancer

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