Associations between liver 18F fluoro-2-deoxy-d-glucose accumulation and various clinical parameters in a Japanese population: influence of the metabolic syndrome

Abstract

BMI was the strongest determinant of liver (18)F-FDG uptake, and the liver (18)F-FDG uptake of metabolic syndrome subjects was significantly higher than that of non-metabolic syndrome subjects. This result suggests that a subject with a high liver (18)F-FDG uptake should be screened for the metabolic syndrome.

The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China

“…A similar result was reported by Kamimura et al [17]. A similar result was reported by Kamimura et al [17].…”

“…A positive impact of BMI on the background liver uptake of 18 F-FDG was reported previously, with β-coefficients reported as ranging from 0.035 to 0.059 [11,14,17]. Our study confirmed that high BMI patients had greater liver 18 F-FDG uptake compared with low BMI patients, although the ApoA, apolipoprotein-A (g/l); ApoB, apolipoprotein-B (g/l); ApoE, apolipoprotein-E (mg/l); BGlu, blood glucose (mg/dl); Lp(a), lipoprotein-a (mg/l); NHDL, non-HDL cholesterol (mmol/l); SUV, standardized uptake value; TC, total cholesterol (mmol/l); TG, triglyceride (mmol/l).…”

“…Numerous authors have used SUV to compare the uptake of 18 F-FDG in lesions with that in normal liver [8][9][10]. However, recent studies have reported that liver 18 F-FDG uptake was vulnerable to variations in age, height, weight, BMI, glucose levels, hepatocellular steatosis, serologic liver enzymes, and serologic lipids [11][12][13][14][15][16][17][18][19][20]. However, recent studies have reported that liver 18 F-FDG uptake was vulnerable to variations in age, height, weight, BMI, glucose levels, hepatocellular steatosis, serologic liver enzymes, and serologic lipids [11][12][13][14][15][16][17][18][19][20].…”

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

“…Other authors also found that in patients with no known diabetes, liver 18 FDG uptake increases with blood glucose level. 13,14 A possible explanation for this phenomenon is that the liver is a key organ responsible for glucose metabolism through gluconeogenesis and glycogen storage. 13 On the other hand, blood glucose level has an opposite effect on tumor uptake, so that many investigators would correct for this parameter.…”

Hepatocyte nuclear factor 1α-inactivated hepatocellular adenomas exhibit high18F-fludeoxyglucose uptake associated with glucose-6-phosphate transporter inactivation

“…In addition, previous reports described the SUV max associated with fat accumulation as high as approximately 3.5 inches. 18,19 However, as the increased FDG uptake associated with H-HCA led to higher SUV max , we suspect that the above-mentioned alternative factors had no significant effect on the increased FDG uptake in the present cases.…”