Associations Between Late-Onset Preeclampsia and the Use of Calcium-Based Antacids and Proton Pump Inhibitors During Pregnancy: A Prospective Cohort Study

Gelder, Marleen M.H.J. van; Beekers, Pim; Rijt-Weetink, Yrea R.J. van; Drongelen, J. van; Roeleveld, Nel; Smits, Luc

doi:10.2147/clep.s382303

Cited by 3 publications

(1 citation statement)

References 60 publications

(101 reference statements)

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“…Van Gelder et al suggests that GERD medication during pregnancy can reduce the risk of pre-eclampsia. However, due to the few relevant prospective randomized controlled trials, it is not enough to make a fair bene t-risk assessment [25]. A review suggests that current machine learning methods can predict preterm birth using different risk factors, of which GERD may be one of the main determinants of preterm birth [26].…”

Section: Discussionmentioning

confidence: 99%

Effects of gastroesophageal reflux disease on adverse pregnancy outcomes: a Mendelian randomization study

Wang,

Lu,

Zhang

et al. 2023

Preprint

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Background More and more studies have shown that gastroesophageal reflux disease (GERD) is negatively associated with adverse pregnancy outcomes (APOs), including spontaneous abortion, gestational diabetes, pre-eclampsia or eclampsia, premature rupture of membranes, premature separation of the placenta, and postpartum hemorrhage. Nevertheless, the causal relationship between the two is not clear. The study aimed to evaluate the causal relationship between GERD and APOs. Methods Based on published genome-wide association studies, two-sample Mendelian randomization (MR) analysis was used to infer the causal relationship between GERD and APOs, in which the fixed-effects inverse variance weighting (IVW) method was the primary method. Various methods were conducted for sensitivity analysis. First, Cochran's Q test assessed heterogeneity among individual SNP estimates. Secondly, MR Egger addressed the pleiotropy effect. Third, a leave-one-out sensitivity analysis was performed to determine whether a single SNP was responsible for the results. Fourth, the funnel plot and forest plot are used to show the pleiotropy directly. Results GERD causally increased the risks of spontaneous abortion (odds ratio (OR) = 1.127, 95% confidence interval (CI) = 1.030–1.233, p = 0.009), gestational diabetes (OR = 1.201, 95% CI = 1.075–1.342, p = 0.001), and pre-eclampsia or eclampsia (OR = 1.183, 95% CI = 1.020–1.372, p = 0.026). No associations were observed for premature rupture of membranes, premature separation of the placenta, or postpartum hemorrhage. No evidence of heterogeneity and directional pleiotropy was detected. The leave-one-out sensitivity analysis revealed that the overall estimates were not disproportionately affected by any individual SNP. Conclusions This two-sample MR analysis found that GERD was positively associated with spontaneous abortion, gestational diabetes, and pre-eclampsia or eclampsia.

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Section: Discussionmentioning

confidence: 99%

Effects of gastroesophageal reflux disease on adverse pregnancy outcomes: a Mendelian randomization study

Wang,

Lu,

Zhang

et al. 2023

Preprint

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Core Data Elements for Pregnancy Pharmacovigilance Studies Using Primary Source Data Collection Methods: Recommendations from the IMI ConcePTION Project

et al. 2023

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Introduction and ObjectiveThe risks and benefits of medication use in pregnancy are typically established through postmarketing observational studies. As there is currently no standardised or systematic approach to the post-marketing assessment of medication safety in pregnancy, data generated through pregnancy pharmacovigilance (PregPV) research can be heterogenous and difficult to interpret. The aim of this article is to describe the development of a reference framework of core data elements (CDEs) for collection in primary source PregPV studies that can be used to standardise data collection procedures and, thereby, improve data harmonisation and evidence synthesis capabilities. Methods This CDE reference framework was developed within the Innovative Medicines Initiative (IMI) ConcePTION project by experts in pharmacovigilance, pharmacoepidemiology, medical statistics, risk-benefit communication, clinical teratology, reproductive toxicology, genetics, obstetrics, paediatrics, and child psychology. The framework was produced through a scoping review of data collection systems used by established PregPV datasets, followed by extensive discussion and debate around the value, definition, and derivation of each data item identified from these systems. ResultsThe finalised listing of CDEs comprises 98 individual data elements, arranged into 14 tables of related fields. These data elements are openly available on the European Network of Teratology Information Services (ENTIS) website (http:// www. entis-org. eu/ cde). Discussion With this set of recommendations, we aim to standardise PregPV primary source data collection processes to improve the speed at which high-quality evidence-based statements can be provided about the safety of medication use in pregnancy.

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Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization

Han,

Wu,

Yao

et al. 2024

IJWH

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Associations Between Late-Onset Preeclampsia and the Use of Calcium-Based Antacids and Proton Pump Inhibitors During Pregnancy: A Prospective Cohort Study

Cited by 3 publications

References 60 publications

Effects of gastroesophageal reflux disease on adverse pregnancy outcomes: a Mendelian randomization study

Effects of gastroesophageal reflux disease on adverse pregnancy outcomes: a Mendelian randomization study

Core Data Elements for Pregnancy Pharmacovigilance Studies Using Primary Source Data Collection Methods: Recommendations from the IMI ConcePTION Project

Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization

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