Associations between Intrinsic Heart Rate, P Wave and QT Interval Durations and Pulse Wave Analysis in Patients with Hypertension and High Normal Blood Pressure

Mozoş, Ioana; Gug, Cristina; Mozos, Costin; Stoian, Dana; Pricop, Marius; Jianu, Dragoş Cătălin

doi:10.3390/ijerph17124350

Cited by 8 publications

(4 citation statements)

References 53 publications

(60 reference statements)

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“…Additional mechanisms that might have a negative impact on the elastic properties of the arterial tree include: the activation of the tissue-specific renin-angiotensin-aldosterone system, increased production of proinflammatory cytokines with an increase in inflammatory markers, a prothrombotic state, and vitamin D deficiency [ 34 , 35 , 36 , 37 ]. Furthermore, heart rate was reported as an independent predictor of PWV in hypertensive patients [ 38 ], but we did not observe a significant association between these variables in our patients. Many non-invasive methods have been used for the assessment of arterial stiffness.…”

Section: Discussioncontrasting

confidence: 91%

Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

et al. 2021

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Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (r = 0.490; P < 0.001) and PWV (r = 0.212; P = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; P < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (P = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension.

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Section: Discussioncontrasting

confidence: 91%

Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

et al. 2021

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“…According to the literature, we report a strong association between insulin resistance, hypertrigliceridemia and ε2 polymorphism, such as direct correlation between insulin resistance and arterial stiffness [ 40 ]; increased QTc duration, cardiac hypertrophy and microalbuminuria were the results of vascular aging and worse ventriculo-arterial coupling in this group [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Involvement of APOE in Incidence of Revascularization in Patients Affected by Peripheral Arterial Disease: A Prospective Study from Southern Italy

Stolfo

Pacilli

Seripa

et al. 2023

JCM

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Introduction. Atherosclerosis is a complex multifactorial disease and apolipoprotein E (APOE) polymorphism has been associated with cardiovascular events. The APOE gene, located on chromosome 19q13.2, has an important role in lipid metabolism, in particular on circulating cholesterol levels, implying further pleiotropic effects; from its polymorphism are derived three alleles (ε2, ε3 and ε4), which induce different phenotypes, while its impact on carotid and femoral atherosclerosis is still controversial. Objectives. The aim of the study is to investigate the relationship between APOE genotypes and peripheral revascularization in a cohort of patients affected by advanced peripheral arterial disease (PAD) at a prolonged follow-up. Materials and methods. Some 332 patients (259 males and 73 females; mean age 70.86 ± 7.95 years) with severe PAD were enrolled in a longitudinal study, with a 90.75 ± 32.25 month follow-up, assessing major adverse cardiovascular events (MACE). Results. As compared with ε3/ε3, in ε4 patients we observed a significant higher incidence of carotid (13.2% vs. 5.6%; HR = 2.485, 95% CI 1.062–5.814; p = 0.036) and lower limb (11.8% vs. 4.3%; HR = 2.765, 95% CI 1.091–7.008; p = 0.032) revascularizations and, accordingly, a higher incidence of total peripheral revascularizations (13.5% vs. 9.5%; HR = 2.705, 95% CI 1.420–5.151; p = 0.002). HR remained statistically significant even when adjusted for classic cardiovascular risk factors. Conclusions. In our observational study, we confirm that the ε4 allele is associated with higher total peripheral revascularization in patients with advanced atherosclerotic vascular disease at prolonged follow-up.

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“…Determining the genetic risk of hypertension before pregnancy is part of high-quality medical care because a proper low-salt diet can increase the chance that the pregnancy will progress to near term and give birth to a healthy baby. Various pathophysiological mechanisms have been involved in the onset of pre-eclampsia [52,53]. A comprehensive literature search of several databases conducted to identify relevant studies that evaluated cell-free fetal DNA levels in pregnant women before the clinical onset of pre-eclampsia revealed that cell-free fetal DNA quantification is a marker predicting the development of pre-eclampsia.…”

Section: Pre-eclampsiamentioning

confidence: 99%

Genetic Counseling and Management: The First Study to Report NIPT Findings in a Romanian Population

et al. 2022

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Background and Objectives: Non-invasive prenatal testing (NIPT) has been confirmed as the most accurate screening test for trisomies 21, 18, 13, sex chromosomes aneuploidies and several microdeletions. This study aimed to assess the accuracy of cell free DNA testing based on low-level whole-genome sequencing to screen for these chromosomal abnormalities and to evaluate the clinical performance of NIPT. Materials and Methods: 380 consecutive cases from a single genetic center, from Western Romania were included in this retrospective study. Cell-free nucleic acid extraction from maternal blood, DNA sequencing and analysis of sequenced regions were performed by BGI Hong Kong and Invitae USA to determine the risk of specific fetal chromosomal abnormalities. In high-risk cases the results were checked by direct analysis of fetal cells obtained by invasive methods: 6 chorionic villus sampling and 10 amniocenteses followed by combinations of QF-PCR, karyotyping and aCGH. Results: NIPT results indicated low risk in 95.76% of cases and high risk in 4.23%. Seven aneuploidies and one microdeletion were confirmed, the other results were found to be a false-positive. A gestational age of up to 22 weeks had no influence on fetal fraction. There were no significant differences in fetal fraction across the high and low risk groups. Conclusions: This is the first study in Romania to report the NIPT results. The confirmation rate was higher for autosomal aneuploidies compared to sex chromosome aneuploidies and microdeletions. All cases at risk for trisomy 21 were confirmed. Only one large fetal microdeletion detected by NIPT has been confirmed. False positive NIPT results, not confirmed by invasive methods, led to the decision to continue the pregnancy. The main limitation of the study is the small number of patients included. NIPT can be used as a screening method for all pregnancies, but in high-risk cases, an invasive confirmation test was performed.

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Associations between Intrinsic Heart Rate, P Wave and QT Interval Durations and Pulse Wave Analysis in Patients with Hypertension and High Normal Blood Pressure

Cited by 8 publications

References 53 publications

Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

Involvement of APOE in Incidence of Revascularization in Patients Affected by Peripheral Arterial Disease: A Prospective Study from Southern Italy

Genetic Counseling and Management: The First Study to Report NIPT Findings in a Romanian Population

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